Interview Topic Guide.

<p>Interview Topic Guide.</p

Body measurements, blood biochemistry and blood pressure measurements in offspring by parental group.

<p>Box-and-whiskers plots show median and IQR (‘<b>+’</b> within the box denotes mean value) for the OMD (white boxes), OFD (hatched boxes) and ONoPD (grey boxes) in males (left) and females (right); box-and whiskers for rest of cohort (RoC, i.e. all those without diabetes excluded from the F₁-offspring groups, [black boxes] for males and females) are also shown for comparison. Graphs are shown for Waist (A), HDL-cholesterol (B), Glucose (C), Systolic-blood pressure (D), Diastolic-blood pressure (E), BMI (F) and Percent body-fat (G). Groups were compared by Kruskal-Wallis, with level of significance between the groups indicated (* P<0.05, **P<0.01, *** P<0.001, **** P<0.0001).</p

The effect of comorbidity on the occurrence of depression and/or angina in GS:SFHS overall.

<p>The effect of comorbidity on the occurrence of depression and/or angina in GS:SFHS overall.</p

Model comparison between the full saturated, the full ACE Cholesky, and the full ADE Cholesky models for chronic pain^± and cardiovascular disease (n = 2,902): Twins UK.

<p>Model comparison between the full saturated, the full ACE Cholesky, and the full ADE Cholesky models for chronic pain<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0170653#t008fn002" target="_blank">^±</a> and cardiovascular disease (n = 2,902): Twins UK.</p

Co-occurrence of chronic pain, major depressive disorder and/or angina in GS:SFHS overall.

<p>Co-occurrence of chronic pain, major depressive disorder and/or angina in GS:SFHS overall.</p

Phenotypic correlations (r) with [95% confidence intervals] between observed variables in TwinsUK (n = 2,902).

<p>Phenotypic correlations (r) with [95% confidence intervals] between observed variables in TwinsUK (n = 2,902).</p

Path diagram of the Cholesky model for the covariance between chronic widespread pain (CWP) and cardiovascular disease (CVD) with adjustment for age.

<p>Path diagram of the Cholesky model for the covariance between chronic widespread pain (CWP) and cardiovascular disease (CVD) with adjustment for age.</p

Study characteristics of the n = 2,902 twins from the TwinsUK cohort.

<p>Study characteristics of the n = 2,902 twins from the TwinsUK cohort.</p

Characteristics of the overall GS:SFHS, unrelated subset and sibling pairs subset^‡.

<p>Characteristics of the overall GS:SFHS, unrelated subset and sibling pairs subset<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0170653#t001fn001" target="_blank">^‡</a>.</p

Phenotypic correlations of MDD status (absent = 0, affected = 1) between kinship dyads.

<p>Estimates from 500 jack-knifed replicates that sampled a single pair from each family for full siblings (N families with one or more pairs = 4306), full sisters (N = 2239), full brothers (N = 1161), opposite sex full-siblings (N = 2426), parent-child (N = 3402), grandparent-grandchild (N = 391), avuncular (aunt/uncle-niece/nephew N = 1826), first cousins (N = 1194).</p