1,620 research outputs found

    A Postcard Autobiography: Jurek Becker’s Unnarrated Response to the Holocaust

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    As the child of German-Polish Jews living in Łódź in the 1930s and ‘40s, Jurek Becker sustained losses—of his mother, of his childhood, and of his memories of that time period—that haunted him long into adulthood. A short autobiographical text that he wrote a few months before his death from cancer in 1997, sent in the form of a postcard to his friend Joachim Sartorius, employs a kind of ellipsis, interestingly unmarked by any typographical symbols, that stands in for those losses. What Becker does not write in his postcard text is as important as what he does write. This essay sheds light on the way in which the gaps in Becker’s text serve as the actual communicators of its theme, expands upon Robyn Warhol’s categories of the “unnarratable,” and explores what Becker’s text might tell us about the concept of the unnarrated in general

    Proteomics and ecotoxicoldgy:.marine invertebrates and endocrine disrupting chemicals

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    The key problem faced by environmental scientists is to predictand recognize the damaging effects of chemical pollutants on natural biota. The aim of this thesis was to evaluate the potential for proteomics in ecotoxicology and environmental risk assessment (ERA), with the hypothesis that proteomic technologies (i.e. ProteinChip technology in combination with SELDI TOF MS) could be a useftil supplement to existing methods of environmental assessment, by providing a sensitive, non-invasive, rapid multi-endpoint assessment of effects of anthropogenic chemicals on organism in vivo. Three invertebrate species, Mytilus edulis, Hyas araneus and Strongylocentrotus droebachiensis was exposed to natural and anthropogenic chemicals in laboratory and field studies. Results revealed that proteomics was a sensitive endpoint, as all exposure regimes significantly affected protein expression. It was shown that plasma protein expression profiles contained information that was compound, dose, site, species and gender-specific. Regarding the latter; male and female organisms responded differently to all exposures both quantitatively (e.g. in terms of number of affected protein species) and qualitatively (e.g. in terms of tj^e of affected protein species). Furthermore, genders have shown opposite responses following the same exposure regime. Equally, species-specific responses were observed. Moreover, exposing organisms to graded levels of contamination under controlled laboratory conditions and in the field revealed that different subsets of proteomes were affected at different levels of exposure. This finding represents an opportunity for appljdng proteomics for both prognostic (e.g. early warning of potential adverse effects or assessment of recovery) and diagnostic purposes. Moreover, those protein features that were changed by all exposure concentrations showed complex dose-response relationships, including both linear and various types of biphasic response-curves. In summary, results from the present study indicate that proteomics have the potential to be a useftil tool in ERA. For example, identification of key molecules could elucidate mechanism of action related to mixture effects, gender and species-specific susceptibility to environmental pollutants as well as dose-response relationships at low doses. Furthermore, key proteins (i.e. putative biomarkers) could, be purified and coupled to e.g. a biosensor for automated monitoring.School of Biological Sciences; International Research Institute of Stavanger (IRIS-BIOMILJ0

    The Relationship Between Land Use Change and Disease Prevalence

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    Zoonotic disease outbreaks are becoming more novel and are increasing in frequency. This increase can be partially attributed to land use changes including deforestation, urbanization, and cultivation. Land use change alters disease prevalence by causing an increase in contact rates between disease hosts and humans. Land use changes also alter species compositions in the area to contain more competent disease hosts. Each pathogen can react to these changes in different ways. The specific reactions that each pathogen has to land use changes should be further researched so proper mitigation steps can be taken. Once the effects of land use change are fully understood then land conversion can occur in a manner that prevents increases in disease prevalence

    Escape to London

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    This tour focuses on the stories of escaped slaves coming to London as London was one of the ends of the Underground Railroad

    R.F.K.

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    Fishing, sailing, climbing . . . taken twice; Kid brother left behind Upsetting carts . . . eating apples. Upstart . . . you legend walk in shoes too big for you. Phenomenon, you\u27re nothing but a restoration, A younger flicker of a deader flame

    In Concert

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    Only they know how to alleluia. Firm, mellowed brown . . . He felt his breast, running hands down. Under a brow . . . eyes. Thrusting into song to the moon Bellowing lust and full-throated blackness..
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