34 research outputs found

    Vitamin D supplementation for the prevention of depression and poor physical function in older persons: the D-Vitaal study, a randomized clinical trial

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    Background: Depressive symptoms and impaired physical functioning are prevalent among older adults. Supplementation with vitamin D might improve both conditions, particularly in persons with low vitamin D status. Objective: The D-Vitaal study primarily aimed to investigate the effect of vitamin D supplementation on depressive symptoms, functional limitations and physical performance in a high-risk older population with low vitamin D status. Secondary aims included examining the effect of vitamin D supplementation on anxiety symptoms, cognitive functioning, mobility, hand grip strength and health-related quality of life. Design: This study was a randomized placebo-controlled trial with 155 participants aged 60-80 years who had clinically relevant depressive symptoms, ≥1 functional limitation and serum 25-hydroxyvitamin D (25(OH)D) concentrations of 15-50/70 nmol/L (depending on season). Participants received 1200 IU/day vitamin D3 (n=76) or placebo tablets (n=77) for 12 months. Serum 25(OH)D was measured at baseline and 6 months; outcomes were assessed at baseline, 6 and 12 months. Linear mixed models analyses were conducted according to the intention-to-treat principle to assess the effect of the intervention. Results: The supplementation increased serum 25(OH)D concentrations in the intervention group to a mean of 85 nmol/L (SD: 16) against 43 nmol/L (SD: 18) in the placebo group after 6 months (P<0.001). No relevant differences between the treatment groups were observed regarding depressive symptoms, functional limitations, physical performance, or any of the secondary outcomes. Conclusions: Supplementation with 1200 IU/day vitamin D for 12 months had no effect on depressive symptoms and physical functioning in older persons with relatively low vitamin D status, clinically relevant depressive symptoms and poor physical functioning. KEYWORDS Vitamin D, 25(OH)D, Depressive symptoms, Physical functioning, Functional limitations, Physical performance, Older adults, Randomized Clinical Trial, Prevention, Supplementation

    Traitement chirurgical des traumatismes iatrogènes de la trachée.

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    Surgical treatment of iatrogenic tracheal traumata. Eight cases of tracheal resection with immediate anastomosis in tracheal stenosis due to prolonged intubation are reported. Resection-anastomosis surgery is compared to recalibration technique.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Bilateral chylothorax after left radical neck dissection

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    Bilateral chylothorax, as a complication of neck dissection, is very rare as evidenced by the 11 cases reported in the literature up to date. We present an additional case of bilateral chylothorax following a left radical neck dissection and concomittant chylous neck fistula. This case was successfully treated by chest drainage and total parenteral nutrition. Early diagnosis of chylothorax is urged due to the consequences on metabolism and respiratory conditions. Management by aspiration drainage is usually sufficient to control pleural effusions.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Clinical advantage of abscess tonsillectomy in peritonsillar abscess

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    Clinical advantage of abscess tonsillectomy in peritonsilar abscess. At the moment, regardless of the prevalence of the peritonsillar abscess (PTA), a definite protocol concerning the treatment of PTA has not yet been established and the treatment remains controversial. In the treatment of PTA the two most used therapeutic approaches are compared in this short study carried out on 16 patients. A group of patients presenting PTA received an abscess tonsillectomy (AT) is compared with another group treated with aspiration and subsequently operated on with interval tonsillectomy (IT). The results show obviously that the abscess tonsillectomy is better than the interval tonsillectomy in every aspect of treatment. The hospitalization time and global costs are also reduced. So when a young person has PTA and once the indication of tonsillectomy is posed, the operation has to be carried out "Ă  chaud".SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Chondroma of the trachea

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    Chondroma of the trachea. The case of a 76 year old man with a progressive upper respiratory distress due to a chondroma of the trachea is reported which necessitated a segmental tracheal resection with end-to-end anastomosis and restoration of the initial tracheal lumen. This case report is illustrative of a rare benign disease (10 cases described till today) originating from the cartilaginous rings of the trachea. The tumor usually appears as an upper airway obstructing syndrome and endoscopy is essential for establishing the diagnosis. Laser resection can be recommended for the treatment of limited lesions, whereas tracheal resection with end-to-end anastomosis is recommended for more advanced chondroma because it is prone to local recurrence and potentially exposed to malignant transformation into chondrosarcoma.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Prognosis of oral cavity carcinomas operated either primarily or secondarily by mandibulectomy and free fibular flap reconstruction

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    Introduction :two different conditions may be encountered :advanced lesions requiring primary radical surgery including mandibulectomy and flap reconstruction and carcinomas relapsing after limited surgery and postoperative XRT secondarily treated by salvage surgery. We present our experience in the management of these potentially aggressive oral cavity tumors. Material :14 oral cavity carcinomas comprizing 8 patients with advanced disease (6T4, 1T3, 1T2N3) who have been treated with mandibulectomy and fibular free flap reconstruction and 6 other patients with recurring carcinomas (2T1, 2T2, 2T4) after XRT or combined surgery with XRT (50-70Gy) who had a radical salvage procedure including mandibulectomy and fibular free flap. Results :oncologic results :among the 8 patients primarily operated, 7 patients are evaluable (1 p.o. death) 5 survived NED on periods from 1 to 5 years. One patient died from local recurrence (6 months) and another one from intercurrent disease (2 years). For the group of 6 patients secondarily operated, no one survived, 5 died from local recurrence (3 to 22 months) and one from intercurrent disease (6 months). Conclusion :we should reconsider our surgical strategy specially for limited T1T2 lesions quite close to the mandibule and recommend a commando procedure including a segmental resection of the mandible and a radical neck dissection. Postoperative XRT should be proposed for not free margins and multiple involved neck nodes.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
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