A new taraxastane-type triterpenoid glycoside from the roots of <i>Clematis uncinata</i>

<div><p></p><p>A new taraxastane-type triterpenoid glycoside, clematiunicinoside I (<b>1</b>), together with four known ones (<b>2–5</b>), was isolated from the roots of <i>Clematis uncinata</i>. The structure of the new compound was elucidated on the basis of spectroscopic analyses and acid hydrolysis. The cytotoxic activities of all the compounds against caski cervical cancer (Caski) cells were evaluated. This is the first report of the presence of taraxastane-type triterpenoid glycoside in the genus <i>Clematis</i>.</p></div

Spongimides A and B, two new alkaloids from the marine sponge <i>Spongia</i> sp.

Two new alkaloids, spongimides A (1) and B (2), along with five known ones (3–7), were isolated from the marine sponge Spongia sp. The structures of 1 and 2 were determined by the spectroscopic methods (UV, IR, MS, and NMR) and X-ray diffraction analysis. Compounds 1, 3, and 4 were the first examples of 2,4-imidazolidinediones isolated from this genus. In addition, the cytotoxic and antibacterial activities of compounds 1 and 2 were also evaluated.</p

Sinulaspirolactam A, a novel aza-spirocyclic valerenane sesquiterpenoid from soft coral <i>Sinularia</i> sp.

<p>A novel valerenane sesquiterpenoid sinulaspirolactam A (<b>1</b>), together with five known compounds, was isolated from the soft coral <i>Sinularia</i> sp. Their structures were determined by spectroscopic analyses. The absolute configuration of <b>1</b> was established by ECD calculation. Compound <b>1</b> was the first example of valerenane sesquiterpenoid bearing an aza-spiro[4.5] ring moiety, the plausible biogenetic pathway of which was proposed. Cytotoxic activities of these compounds were also evaluated.</p

A new α-pyrone from the deep-sea actinomycete <i>Nocardiopsis dassonvillei</i> subsp. <i>dassonvillei</i> DSM 43111(T)

<p>A new α-pyrone, nocapyrone S (<b>1</b>), together with five known compounds (<b>2-6</b>), were isolated from the deep-sea actinomycete <i>Nocardiopsis dassonvillei</i> subsp. <i>dassonvillei</i> DSM 43111(T). Their structures were determined by spectroscopic analyses. The absolute configuration of <b>1</b> was established by quantum approaches. Cytotoxic activity of <b>1</b> was evaluated against K562, MCF-7, SGC7901, A375, Hela, and HepG2 cell lines.</p

Aspergchromones A and B, two new polyketides from the marine sponge-associated fungus <i>Aspergillus</i> sp. SCSIO XWS03F03

<p>Two new polyketides, aspergchromones A (<b>1</b>) and B (<b>2</b>), together with five known compounds, secalonic acid D (<b>3</b>), noreugenin (<b>4</b>), (3<i>S</i>)-5-hydroxymellein (<b>5</b>), (4<i>S</i>)-6-hydroxyisosclerone (<b>6</b>), and (-)-regiolone (<b>7</b>), were isolated from the ethyl acetate extract of marine sponge-derived fungus <i>Aspergillus</i> sp. SCSIO XWS03F03. Their structures were elucidated by means of spectroscopic techniques (1D and 2D NMR, MS, UV, and IR). The absolute configurations of the new compounds were established by ECD calculations. Compound <b>3</b> showed moderate antimicrobial activity.</p

(+)- and (−)-Cajanusine, a Pair of New Enantiomeric Stilbene Dimers with a New Skeleton from the Leaves of Cajanus cajan

A pair of new enantiomeric stilbene dimers, (+)- and (−)-cajanusine [(+)-<b>1</b> and (−)-<b>1</b>], with a unique coupling pattern were isolated from the leaves of Cajanus cajan. Their structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic and single-crystal X-ray diffraction analyses, as well as CD calculations. The plausible biogenetic pathway of <b>1</b> was also proposed. Additionally, (±)-<b>1</b>, (+)-<b>1</b>, and (−)-<b>1</b> exhibited inhibitory activities on the growth of human hepatocellular carcinoma cells

(+)- and (−)-Cajanusine, a Pair of New Enantiomeric Stilbene Dimers with a New Skeleton from the Leaves of Cajanus cajan

A pair of new enantiomeric stilbene dimers, (+)- and (−)-cajanusine [(+)-<b>1</b> and (−)-<b>1</b>], with a unique coupling pattern were isolated from the leaves of Cajanus cajan. Their structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic and single-crystal X-ray diffraction analyses, as well as CD calculations. The plausible biogenetic pathway of <b>1</b> was also proposed. Additionally, (±)-<b>1</b>, (+)-<b>1</b>, and (−)-<b>1</b> exhibited inhibitory activities on the growth of human hepatocellular carcinoma cells

(+)- and (−)-Cajanusine, a Pair of New Enantiomeric Stilbene Dimers with a New Skeleton from the Leaves of Cajanus cajan

A pair of new enantiomeric stilbene dimers, (+)- and (−)-cajanusine [(+)-<b>1</b> and (−)-<b>1</b>], with a unique coupling pattern were isolated from the leaves of Cajanus cajan. Their structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic and single-crystal X-ray diffraction analyses, as well as CD calculations. The plausible biogenetic pathway of <b>1</b> was also proposed. Additionally, (±)-<b>1</b>, (+)-<b>1</b>, and (−)-<b>1</b> exhibited inhibitory activities on the growth of human hepatocellular carcinoma cells

(+)- and (−)-Cajanusine, a Pair of New Enantiomeric Stilbene Dimers with a New Skeleton from the Leaves of Cajanus cajan

A pair of new enantiomeric stilbene dimers, (+)- and (−)-cajanusine [(+)-<b>1</b> and (−)-<b>1</b>], with a unique coupling pattern were isolated from the leaves of Cajanus cajan. Their structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic and single-crystal X-ray diffraction analyses, as well as CD calculations. The plausible biogenetic pathway of <b>1</b> was also proposed. Additionally, (±)-<b>1</b>, (+)-<b>1</b>, and (−)-<b>1</b> exhibited inhibitory activities on the growth of human hepatocellular carcinoma cells

Virosaines A and B, Two New Birdcage-Shaped <i>Securinega</i> Alkaloids with an Unprecedented Skeleton from <i>Flueggea virosa</i>

Two new <i>Securinega</i> alkaloids, virosaines A (<b>1</b>) and B (<b>2</b>), were isolated from the twigs and leaves of <i>Flueggea virosa</i>. The structures and absolute configurations were elucidated by means of NMR, X-ray diffraction, and CD analyses. Compounds <b>1</b> and <b>2</b> represent the first examples of <i>Securinega</i> alkaloids bearing a 7-oxa-1-azabicyclo[3.2.1]octane ring system, whose plausible biogenetic pathways were also proposed