Penguins Can\u27t Fly and Women Don\u27t Count: Language and Thought

Many people object to sexist and racist language partly because they assume that language not only reflects, but somehow affects attitudes. A one-to-one relationship between language and thought seems obvious to those who never question it, but the issue of whether language influences thought and behavior has been a matter of debate in philosophy even before Berkeley and Wittgenstein. Literary critics, particularly those who call themselves deconstructionists, are still debating to what extent language constructs reality

Is Feminist Humor an Oxymoron?

Is the subject of feminist humor male oppression or a celebration of the female experience? This paper argues for the latter and suggests that inclusive jokes can be more effectively subversive than divisive ones. As long as women\u27s jokes focus on men, male definitions, and male behavior, women are marginalizing females, even if their jokes target males. In addition, divisive jokes can strengthen prevailing beliefs about essential female-male differences. However, when straight feminists make jokes and laugh about the shared experiences of females rather than on oppressive male behavior, then feminist humor, like lesbian humor, becomes an agent for change

Gotcha: What Social Activists Can Learn from Pranksters

It is unfortunate that, even today, feminist messages too often go unheard and feminist issues are too often dismissed by mainstream audiences, partly because feminists continue to be stereotyped as angry and humorless. Yet some social activists use pranks to draw attention to important issues because humor is one strategic way to send messages about sexism to those who may discount ideas presented in a more direct manner. Although there have been relatively few successful feminist pranksters, humor is increasingly being used to convey women\u27s issues in a growing number of feminist blogs and videos. This essay explores pranking and humor as social activism, and considers the potential of using humor to bring attention to feminist messages

Brain Sex: How the Media Report and Distort Brain Research

Testosterone gives men a particular advantage in that it is focusing and galvanizing a brain that is already, by its very structure, more focused than the female. Remember that the male brain is a tidier affair, each function in its special place . . . Biology, then, every bit as much as social conditioning, militates against a strongly feminine role in areas traditionally regarded as male preserves

How Many Lesbians Does It Take to Screw in a Light Bulb?

This paper explores how humor reveals shared aspects of a culture of lesbian communities in the US. For lesbians, jokes and other forms of humor are an active, narrative means of self-construction and community imagining that help lesbians negotiate their positions both inside and outside mainstream culture. Whether consciously or unconsciously, much of lesbian humor challenges the dominant culture by rejecting its definitions of and presuppositions about lesbians, and by making lesbian experience central to its understanding of normalcy. Whereas the term lesbian joke usually activates a sex frame for the dominant culture, much humor created by and for lesbians is based on a switch from a sex frame to a non-sex frame. When lesbian jokes are about sex, they affirm the right not only to private sex, but also to public representation. Perhaps the most surprising aspect of lesbian humor is what it does not include. For the most part there are no references to heterosexuality, to harassment or to oppression, but many references to a self-empowering, self-conscious community based on cooperative principles

Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing.

UnlabelledLinezolid resistance is uncommon among staphylococci, but approximately 2% of clinical isolates of coagulase-negative staphylococci (CoNS) may exhibit resistance to linezolid (MIC, ≥8 µg/ml). We performed whole-genome sequencing (WGS) to characterize the resistance mechanisms and genetic backgrounds of 28 linezolid-resistant CoNS (21 Staphylococcus epidermidis isolates and 7 Staphylococcus haemolyticus isolates) obtained from blood cultures at a large teaching health system in California between 2007 and 2012. The following well-characterized mutations associated with linezolid resistance were identified in the 23S rRNA: G2576U, G2447U, and U2504A, along with the mutation C2534U. Mutations in the L3 and L4 riboproteins, at sites previously associated with linezolid resistance, were also identified in 20 isolates. The majority of isolates harbored more than one mutation in the 23S rRNA and L3 and L4 genes. In addition, the cfr methylase gene was found in almost half (48%) of S. epidermidis isolates. cfr had been only rarely identified in staphylococci in the United States prior to this study. Isolates of the same sequence type were identified with unique mutations associated with linezolid resistance, suggesting independent acquisition of linezolid resistance in each isolate.ImportanceLinezolid is one of a limited number of antimicrobials available to treat drug-resistant Gram-positive bacteria, but resistance has begun to emerge. We evaluated the genomes of 28 linezolid-resistant staphylococci isolated from patients. Multiple mutations in the rRNA and associated proteins previously associated with linezolid resistance were found in the isolates investigated, underscoring the multifocal nature of resistance to linezolid in Staphylococcus. Importantly, almost half the S. epidermidis isolates studied harbored a plasmid-borne cfr RNA methylase gene, suggesting that the incidence of cfr may be higher in the United States than previously documented. This finding has important implications for infection control practices in the United States. Further, cfr is commonly detected in bacteria isolated from livestock, where the use of phenicols, lincosamides, and pleuromutilins in veterinary medicine may provide selective pressure and lead to maintenance of this gene in animal bacteria

Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors

Background: About half of all prostate cancers harbor the TMPRSS2:ERG (T2E) gene fusion. While T2E-positive and T2E-negative tumors represent specific molecular subtypes of prostate cancer (PCa), previous studies have not yet comprehensively investigated how these tumor subtypes differ at the epigenetic level. We therefore investigated epigenome-wide DNA methylation profiles of PCa stratified by T2E status. Results: The study included 496 patients with clinically localized PCa who had a radical prostatectomy as primary treatment for PCa. Fluorescence in situ hybridization (FISH) "break-apart" assays were used to determine tumor T2E- fusion status, which showed that 266 patients (53.6 %) had T2E-positive PCa. The study showed global DNA methylation differences between tumor subtypes. A large number of differentially methylated CpG sites were identified (false-discovery rate [FDR] Q-value Conclusions: This study identified substantial differences in DNA methylation profiles of T2E-positive and T2E-negative tumors, thereby providing further evidence that different underlying oncogenic pathways characterize these molecular subtypes