Synthesis and biological evaluation of novel <i>N</i>-pyridylpyrazolecarboxamides containing benzothiazole

<p></p> <p>A series of novel <i>N</i>-pyridylpyrazolecarboxamides containing benzothiazole were designed and synthesized. The target compounds were identified by ¹H NMR,¹³C-NMR, IR, high-resolution mass spectrum (HRMS) and elemental analysis. The bioactivities of the new compounds against oriental army worm (<i>Mythimnaseparata</i>) and diamond back moth <i>(Plutellaxylostella</i>) were evaluated. The results of bioassays indicated that some of the compounds showed good activitiesat the tested concentrations. Compound <b>Ij</b> showed 100% larvicidal activities against <i>Plutellaxylostella</i> at 2.5 mg/L, while the activity of <b>Ij</b> against <i>Mythimnaseparata</i> was 100% at 10 mg/L.</p

Synthesis and biological activity of ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylate

<p>A series of novel ethyl 2-(5-methyl-3-arylisoxazole-4-carboxamido)-4-alkylthiazole-5-carboxylates <b>I-1</b>-<b>6</b> were synthesized. The structures of all target compounds were characterized by ¹H NMR, ¹³C NMR, IR, MS and elemental analyses. Their fungicidal and herbicidal activities were evaluated. The results of preliminary bioassays show that the title compounds <b>I-4</b> possess 20–50% inhibition against most of the tested plants at the dosage of 150 g ai/ha, while the title compounds <b>I-1-5</b> possess 32–58% inhibition against <i>FusaHum graminearum, Thanatephorus cucumeris, Botrytis cinereapers</i> and <i>Fusarium oxysporum in vitro</i> at the concentration of 100 mg/L.</p