SPICE: the connection between cosmic reionisation and stellar feedback in the first galaxies

We present SPICE, a new suite of RHD cosmological simulations targeting the epoch of reionisation. The goal of these simulations is to systematically probe a variety of stellar feedback models, including "bursty" and "smooth" forms of supernova energy injection, as well as poorly-explored scenarios such as hypernova explosions and radiation pressure. Subtle differences in the behaviour of supernova feedback drive profound differences in reionisation histories, with burstier forms of feedback causing earlier reionisation. We also find that some global galaxy properties, such as the dust-attenuated luminosity functions and star formation main sequence, remain degenerate between models. Stellar feedback and its strength determine the morphological mix of galaxies emerging by z = 5 and that the reionisation history is inextricably connected to intrinsic properties such as galaxy kinematics and morphology. While star-forming, massive disks are prevalent if supernova feedback is "smooth", "bursty" feedback preferentially generates dispersion-dominated systems. Different modes of feedback produce different strengths of outflows, altering the ISM/CGM in different ways, and in turn strongly affecting the escape of LyC photons. We establish a correlation between galaxy morphology and LyC escape fraction, revealing that dispersion-dominated systems have escape fractions 10-50 times higher than their rotation-dominated counterparts at all redshifts. Dispersion-dominated systems should thus preferentially generate large HII regions as compared to their rotation-dominated counterparts. Since dispersion-dominated systems are more prevalent if stellar feedback is more explosive, reionisation occurs earlier in our simulation with burstier feedback. Statistical samples of post-reionisation galaxy morphologies probed with JWST, ALMA and MUSE can constrain stellar feedback and models of cosmic reionisation

Malignant transformation of lichen planus hypertrophicus into squamous cell carcinoma

Neoplastic transformation of lichen planus (LP) is reported, but it's a rare event. Squamous cell carcinoma (SCC) complicating cutaneous LP has an incidence of 0.4%. Average age at the time of diagnosis of SCC in patients of LP is 58 years with a range of 29–78 years. We report an extremely rare case of 17-year-old female patient who developed SCC from lichen planus hypertrophicus (LPH), a variant of LP. Patient presented with LPH over the anterior aspect of both legs since the age of 7 years which is again a pediatric rarity. SCC developed over an anteromedial aspect of left ankle after 10 years when she came to us. Both the diagnoses were histopathologically confirmed. The patient was treated with complete excision of tumor and defect was closed with rotation flap. This report emphasizes that the long-standing hypertrophic form of LP seems to have a considerable propensity for malignant transformation, even in the juvenile age group. Hence, careful vigilance of a longstanding LPH is necessary to allow early detection of a developing SCC

To evaluate effect of three different reducing agents in recovery of bond strength to sodium hypochlorite treated dentin with composite resin: An in vitro study

Background: Endodontically treated teeth lose a large proportion of their structure due to trauma and caries and during endodontic treatment. As a result, they have low physical properties, fracture resistance, and esthetic appearance. The study aims to evaluate the anti-oxidant efficacy of sodium thiosulphate, citric acid and gallic acid on the recovery of shear bond strength to pulp chamber dentin treated with NaOCI & EDTA. Methodology: 50 single rooted second premolars were divided into 5 groups (n=10); Positive control received no treatment; negative control received only irrigation treatment, while the other two experimental groups were treated with their respective anti-oxidant following the irrigation. All the samples were then cured with composite and subjected to SBS test under a universal testing machine. Statistical analysis: ANOVA & Post hoc tukey were used with P <0.5. Results: Anti-oxidant groups showed a greater mean SBS value than the negative control, comparable to positive control. The sodium thiosulfate group showed the highest value with a significant difference from the negative control group. Conclusion: Both the anti-oxidants used were able to restore the Shear bond strength of pulp chamber dentin altered due to endodontic irrigants. Hence, possesses great potential in its clinical implication

2,4,6-Trimethoxy chalcone derivatives: an integrated study for redesigning novel chemical entities as anticancer agents through QSAR, molecular docking, ADMET prediction, and computational simulation

QSAR, an efficient and successful approach for optimizing lead compounds in drug design, was employed to study a reported series of compounds derived from 2,4,6-trimethoxy chalcone derivatives. The ability of these compounds to inhibit CDK1 was examined, with the help of QSARINS software for model development. The generated QSAR model revealed three significant descriptors, exhibiting strong correlations with impressive statistical values: cross-validation leave-one-out correlation coefficient (Q2LOO) = 0.6663, coefficient of determination (R2) = 0.7863, external validation coefficient (R2ext) = 0.7854, cross-validation leave-many-out correlation coefficient (Q2LMO) = 0.6256, Concordance Correlation Coefficient for cross-validation (CCCcv) = 0.8150, CCCtr = 0.8804, and CCCext = 0.8750. From the key structural findings and the insights gained from the descriptors, ETA_dPsi_A, WTPT-5, and GATS7s, new lead molecules were designed. The designed molecules were then evaluated for their CDK1 inhibitory activity using the three-descriptor model developed in this study. To evaluate their drug likeliness, in-silico ADMET predictions were made using Schrodinger’s Software. Molecular docking was carried out to determine the interactions of designed compounds with the target protein. The designed compounds having excellent binding pocket molecular stability and anticancer effectiveness was substantiated by the findings of the molecular dynamics simulation. The results of this work point out important properties and crucial interactions necessary for efficient protein inhibition, suggesting lead candidates for further development as novel anticancer agents. Communicated by Ramaswamy H. Sarma</p