Planck LFI flight model feed horns

this paper is part of the Prelaunch status LFI papers published on JINST: http://www.iop.org/EJ/journal/-page=extra.proc5/jinst The Low Frequency Instrument is optically interfaced with the ESA Planck telescope through 11 corrugated feed horns each connected to the Radiometer Chain Assembly (RCA). This paper describes the design, the manufacturing and the testing of the flight model feed horns. They have been designed to optimize the LFI optical interfaces taking into account the tight mechanical requirements imposed by the Planck focal plane layout. All the eleven units have been successfully tested and integrated with the Ortho Mode transducers.Comment: This is an author-created, un-copyedited version of an article accepted for publication in JINST. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at 10.1088/1748-0221/4/12/T1200

Nivolumab plus Ipilimumab in Non-Small-Cell Lung Cancer

To the Editor: Although more than 10% of the patients in the CheckMate 227 trial conducted by Hellmann et al. (Nov. 21 issue)(1) had never smoked, the effect of smoking status on survival was not fully discussed. Striking differences in the clinical and molecular characteristics of lung cancers between smokers and those who have never smoked have been identified, suggesting that the cancers are separate entities.(2) In one trial,(3) patients who had never smoked had poorer responses to nivolumab (as compared with docetaxel) than current or former smokers (hazard ratio for overall survival, 1.02 vs. 0.70). In a meta-analysis involving . .

Full Sky Study of Diffuse Galactic Emission at Decimeter Wavelengths

A detailed knowledge of the Galactic radio continuum is of high interest for studies of the dynamics and structure of the Galaxy as well as for the problem of foreground removal in Cosmic Microwave Background measurements. In this work we present a full-sky study of the diffuse Galactic emission at frequencies of few GHz, where synchrotron radiation is by far the dominant component. We perform a detailed combined analysis of the extended surveys at 408, 1420 and 2326 MHz (by Haslam et al. 1982, Reich 1982, Reich & Reich, 1986 and Jonas et al. 1998, respectively). Using the technique applied by Schlegel et al. (1998) to the IRAS data, we produce destriped versions of the three maps. This allows us to construct a nearly-full-sky map of the spectral index and of the normalization factor with sub-degree angular resolution. The resulting distribution of the spectral indices has an average of beta = 2.695 and dispersion sigma_{beta} = 0.120. This is representative for the Galactic diffuse synchrotron emission, with only minor effects from free-free emission and point sources.Comment: 10 pages, 16 jpeg figures, accepted to Astronomy & Astrophysics, Comments and figure adde

Anisotropies of the Cosmic Microwave Background

We review the present status of Cosmic Microwave Background (CMB) anisotropy observations and discuss the main related astrophysical issues, instrumental effects and data analysis techniques. We summarise the balloon-borne and ground-based experiments that, after COBE-DMR, yielded detection or significant upper limits to CMB fluctuations. A comparison of subsets of combined data indicates that the acoustic features observed today in the angular power spectrum are not dominated by undetected systematics. Pushing the accuracy of CMB anisotropy measurements to their ultimate limits represents one of the best opportunities for cosmology to develop into a precision science in the next decade. We discuss the forthcoming sub-orbital and space programs, as well as future prospects of CMB observations.Comment: 83 pages, 16 figures. Revised version, accepted by "La Rivista del Nuovo Cimento

The Optical Emission from Gamma-ray Quasars

We present photometric observations of six radio-loud quasars that were detected by the COMPTEL gamma-ray telescope. The data encompasses seven wavebands in the optical and near-infrared. After correction for Galactic extinction, we find a wide range in optical slopes. Two sources are as blue as optically-selected quasars, and are likely to be dominated by the accretion disc emission, while three others show colours consistent with a red synchrotron component. We discuss the properties of the COMPTEL sample of quasars, as well as the implications our observations have for multi-wavelength modelling of gamma-ray quasars.Comment: 12 pages, 3 figures, accepted for publication in P.A.S.A; minor typos correcte