Drugs and herbs in two divergent lines of benign prostatic hyperplasia therapy

Prostatic adenoma, or benign prostate hypertrophy (BPH), is a natural and common disease in elderly men. Its etiology is multifactorial. BPH is associated with annoying symptoms and morbid complications. The treatment of BPH with drugs, or synthetic chemicals, damages hepatic and renal tissues developing cirrhosis and kidney failure. As an alternative, there has been recourse to the use of medicinal plants or natural health. Pumpkin seeds, nettle leaves and soybeans have been proven to be potent against pain and discomfort in BPH patients. Moreover, plants used at high doses during a long period as treatment, may be toxic and complicate the lifestyle of BPH patients. Both, drugs and plants, used without precaution is a dilemma of prevention and toxicity. The patients simultaneously consume the drug and plants to anticipate healing. Combined drug-plant therapy could have harmful effects on health due to an accumulating antagonistic synergy of chemical and natural.

Utility of Combination of Diagnostic Tests in Early Detection of Prostate Tumors in West

Abstract In West of Algeria, incidence of prostate cancer (PCa) is growing and epidemiological data on benign prostatic hyperplasia (BPH) are contradictory. The prostate specific antigen (PSA) joins other tests, as digital rectal examination (DRE) and ultrasound, for better management of patient. This study aimed to assess the association of previously tests with PSA-assay in diagnosis of PCa and BPH, in West Algeria. A retrospective study was performed on two groups of 234 BPH and 56 PCa diagnosed between 2010-2012 at the urology department of the hospital in Saida. Patients underwent various diagnostic tests; DRE, ultrasound, PSA and pathological examination. BPH is more common than PCa and the most dominant age group was from 70 to 79 years. DRE was positive in 67 % of BPH and 63.3 % Pca. Ultrasound examination revealed that the prostatic structure was heterogeneous in 25.5 % of BPH and 92 % PCa. Total PSA (TPSA) was higher than the cut-off value of 4 ng / ml in 37% of BPH and 75 % PCa. Histological forms of Prostatic adenomyofibroma and prostatic adenocarcinoma were the most represented. This study shows that the combination of different tests is more efficient than using a test alone for a definitive diagnosis of PCa or BPH

Contribution of Diagnostic Tests and Drug Therapy in Screening of Benign Prostatic Hyperplasia (BPH) in Western

Abstract The incidence of benign prostatic hyperplasia (BPH) is known through the American and European continents whereas it remains much to make to know the epidemiologic profile of this pathology in Algeria. This study aims to show a contribution of diagnostic tests and drug therapy in screening of BPH in Western Algerian hospital. Our study was carried out on 385 men recruited in the Urology department of Saida hospital during the period 2010-2013, consulting for urologic problems whose 120 patients, aged between 45-84 years, have BPH. BPH frequency was 31.1 %. It was prevalent in the age -specific range of 65-74 years. The physical, biological and histological examinations revealed that 75 % of the patients were diagnosed by digital rectal examination (DRE), 70 % have serum-TPSA level lower than 4 ng/ml and 71.2 % have a histological type named "prostatic hyperplasia adeno-fibro-Leio myomatic (or PHAFLM)". As for an assumption of responsibility concerning BPH patients 52.7 % have chosen a medical treatment. This work showed the proportion of the subjects carrying BPH in this area of Algeria. This study provides information on the incidence of BPH in this area of Algeria. But more work needs to come to reinforce the results to uncover the various risk factors (age, race, diet, hormones) that are behind the development of this disease. Keywords: Incidence; benign prostatic hyperplasia; urology; TPSA. Introduction Benign prostatic hyperplasia (BPH) is a common urological disease in older men. BPH, known as nodular hyperplasia, is a disease characterized by histological changes in the prostate glan

Effects of interaction CdZn on serum-PSA level and prostate histology in rats

Objective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats. Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days. Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study. Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland