28-Day All-Cause Mortality: Hospital-wide Prevention Programme for Central Line-Associated Bloodstream Infection, University of Geneva Hospitals, 2008–2011.

<p>CI: confidence interval.</p><p>CLABSI: central line-associated bloodstream infection.</p><p>CVC: central venous catheter.</p><p>ICU: intensive care unit.</p><p>OR: odds ratio.</p><p>95% CI: 95% confidence interval.</p>1<p>Quarter: modelled as per additional quarter.</p>2<p>Age: modelled as per additional year of age.</p>3<p>Gender: modelled as male vs. female.</p>4<p>Charlson index: modelled as per score-point increase.</p>5<p>Emergency admission: modelled as yes/no.</p>6<p>ICU stay: hospitalization in the intensive care unit at any time; modelled as yes/no.</p>7<p>Central line-associated bloodstream infection at any time during hospitalization; modelled as yes/no.</p>8<p>Number of CVCs during hospitalization; modelled as per additional catheter.</p

Factors Associated with Central Line-Associated Bloodstream Infections: Hospital-wide Prevention Programme for Central Venous Catheter-Associated Bloodstream Infections, University of Geneva Hospitals, 2008–2011.

<p>ICU: intensive care unit</p><p>IRR: incidence rate ratio.</p><p>95% CI: 95% confidence interval.</p>1<p>Quarter: modelled as per additional quarter.</p>2<p>Age: modelled as per additional year of age.</p>3<p>Gender: modelled as male vs. female.</p>4<p>Charlson score: modelled as per score-point increase.</p>5<p>ICU stay: hospitalization in the intensive care unit; modelled as yes vs. no.</p>6<p>Multilumen catheters: any catheter with more than 1 lumen; modelled as yes/no.</p>7<p>Femoral position: any catheter inserted at the femoral site; modelled as yes/no.</p>8<p>Dwell-time (quartiles): 2^nd (4–6 days), 3^rd (7–12 days), and 4^th (>12 days) quartile as compared with the first quartile (1–3 days).</p

Central Line-Associated Bloodstream Infections and Number of Trained Healthcare Workers, Hospital-wide Prevention Programme, University of Geneva Hospitals, 2008–2011.

<p>CLABSI: central line-associated bloodstream infection IRR: incidence rate ratio 95% CI: 95% confidence interval.</p

Characteristics of Patients With and Without Central Line-Associated Bloodstream Infection, University of Geneva Hospitals, 2008–2011.

<p>CLABSI: central line-associated bloodstream infection.</p><p>NA: not applicable.</p><p>IQR: interquartile range.</p><p>ICU: intensive care unit.</p>#<p>A total of 189,643 patients were admitted during the study period.</p><p>*As per hospitalization (n = 4,452).</p

Frequencies of analgesia, delirium and sedation monitoring in participating intensive care units.

<p>Reported frequencies include validated as well as non-validated methods.</p><p>Frequencies of analgesia, delirium and sedation monitoring in participating intensive care units.</p

Distribution of Pathogens: Hospital-wide Prevention Programme for Central Line-Associated Bloodstream Infection, University of Geneva Hospitals, 2008–2011.

<p>Distribution of Pathogens: Hospital-wide Prevention Programme for Central Line-Associated Bloodstream Infection, University of Geneva Hospitals, 2008–2011.</p

Methods and results of analgesia, delirium and sedation monitoring among included patients.

<p>Methods and results of monitoring that was actually performed in included patients (questionnaire part two). *NRS or VRS or VAS>4 or BPS>5. **RASS <−2 or Ramsay >2 or SAS <4. CAM-ICU, Confusion Assessment Method for the Intensive Care Unit. DDS, Delirium Detection Score. ICDSC, Intensive Care Delirium Screening Checklist.</p><p>Methods and results of analgesia, delirium and sedation monitoring among included patients.</p

Demographic and clinical characteristics of included patients.

<p>*Continuous variables are presented as medians with interquartile range [25th to 75th]. IMV, invasive mechanical ventilation.</p><p>Demographic and clinical characteristics of included patients.</p

Pharmacological treatment strategies for delirium as applied by the participating intensive care units.

<p>APDs, antipsychotics (e.g. haloperidol). BDZs, benzodiazepines. * adrenergic agonist, selective serotonin re-uptake inhibitors.</p><p>Pharmacological treatment strategies for delirium as applied by the participating intensive care units.</p

Characteristics of participating intensive care units.

<p>Characteristics of participating intensive care units.</p