Interventions and instruments to promote sustainable land use in Europe

Since the first examples of human settlements, land has been subject to transformations. With the industrial revolution and in particular after the Second World War, land transformation has become more intense in terms of overexploitation of natural resources. Only recently, however, have policy and decision makers acknowledged the importance of land as a finite resource. Sustainable development has increasingly become the subject of many studies and a reason for debate, leading to different lines of thought among the various disciplines. This has led to the design and implementation of a great number of sustainable land use practices in many European cities and regions. In fact, it seems that sustainability of land use depends both on the socio-economic processes that trigger spatial development and the effectiveness of the instruments that regulate these processes (Solly et al., 2020). The need for a more sustainable and eco-compatible approach, and the European objective to achieve zero net land take 2050 (Science for Environment Policy, 2016), have been one of the reasons why ESPON launched the pan-European research project SUPER – Sustainable Urbanization and land-use in the European Regions. The project examines, on the one hand, the nature and the structure of urbanization processes and, on the other, it seeks to analyze the degree of success of interventions and instruments aiming at a more sustainable use of land. This contribution presents the results of the project by focusing especially on the content of the SUPER “Guide to Sustainable Urbanisation and Land Use” (Cotella et al., 2020). Thanks to the exploration of more than two hundred examples of urbanization interventions gathered all over Europe, the guide suggests a set of policy recommendations for policy and decision makers in order to address land use in a more sustainable perspective. According to the different objectives and contextual needs, policy and decision makers should focus more on: (i) which intervention (i.e. densification, regeneration, containment, governance and sectoral policies) and (ii) which instrument, should be used (i.e. visions and strategies, rules and legal devices, land use regulations, programmes and projects)

METRO - The role and future perspectives of Cohesion Policy in the planning of Metropolitan Areas and Cities. Policy brief: The added value of the EU cohesion policy in the planning and implementation of metropolitan policies

This policy brief seeks to unpack the multiple added value of the European Union (EU) cohesion policy in metropolitan areas by exploring its priorities, funds and geographical distribution as well as the successful outcomes. Starting from the idea that the metropolitan scale is the most relevant to deal with those ‘functional’ issues that have a scope that exceeds the municipal boundaries (such as mobility, economic development, climate change etc.), this policy brief offers an overview of the added value of the EU cohesion policy on the planning and implementation of metropolitan policies in the 2014-20 programming period and elaborates a set of recommendations for policy and decision makers aiming at increasing this added value in the programming period 2021-27. Based on the nine case studies explored in the ESPON METRO targeted analysis, which include the metropolitan areas of Barcelona, Brno, Brussels, Florence, Gdańsk-Gdynia-Sopot, Lisbon, Lyon, Riga and Turin, this policy brief aims to support planners and policy officers in making well-informed decisions at EU, national and local level, when it comes to maximise the added value that the EU cohesion policy can provide to metropolitan development and policies. It does so by presenting possible ways of dealing with the complexity of the multiple impacts of cohesion policy and its metropolitan dimension

ESPON SUPER – Sustainable Urbanisation and land-use Practices in European Regions. A GUIDE TO SUSTAINABLE URBANISATION AND LAND-USE

Guides help you do things. You turn to them when you need to find out how to solve a problem. They are a form of knowledge transfer, written by experts in a way that is accessible and helpful to a wide audience. This guide was written by the researchers engaged in the ESPON 2020 applied research project on Sustainable Urbanisation and Land-Use Practices in European Regions (SUPER). It aims to help people and institutions engaged with land-use management at various levels across Europe to promote sustainable urbanisation in their territories. Overall, the guide offers information, ideas and perspectives to help decision-makers and policymakers to proactively contribute to more equal, balanced, and sustainable territorial development. The decision to convert land to a different use influences our quality of life and that of future generations, and, as this Guide shows, a large toolbox of interventions exists that can help alter prevailing land-use practices. Choosing among them is a tough decision, and implementation may require strong political commitment and bold leadership. We hope that this Guide provides the inspiration to accept this challenge

METRO - The role and future perspectives of Cohesion Policy in the planning of Metropolitan Areas and Cities. Annex II: The role of Metropolitan areas within the EU cohesion policy

This Annex to the final Report presents and discusses in a comparative manner the evidence collected in the nine case studies that have been explored in the framework of the ESPON Targeted Analysis METRO – The role and future perspectives of cohesion policy in the planning of Metropolitan Areas and Cities (Annexes III to XI). More in detail, the document synthesizes and compares the information collected by the various research teams through the application of the project’s analytical protocol and as a consequence of their continuous interaction with the respective stakeholders. The report is organised following the three main policy questions that have been driving the analysis: PQ1 | What role do metropolitan areas and cities play in the development, management and implementation of the European Union (EU) cohesion policy? PQ2 | What is the added value of the EU cohesion policy in the planning and implementation of metropolitan policies? PQ3 | What role does the EU cohesion policy play in consolidating metropolitan governance and cooperation? These questions are answered through the comparative analysis and assessment of the territorial and institutional contexts in which the nine stakeholders involved in the projects are active: Metropolitan City of Turin (CMTo), Barcelona Metropolitan Area (AMB), Lisbon Metropolitan Area (LMA), Brno Metropolitan Area (BMA), Metropolitan Area of Gdańsk-Gdynia-Sopot (MAG), Metropolitan City of Florence (CMFi), Métropole de Lyon (MdL), Brussels-Capital Region (BCR), Riga Metropolitan Area (RMA)

Europeizzazione del governo del territorio. Un’analisi comparativa

Secondo la letteratura tecnica, il concetto di “Europeizzazione” riguarda gli effetti del processo di mutuo adattamento dei contesti istituzionali interessati dall’integrazione europea. Il concetto ha iniziato a essere utilizzato anche nel campo del governo del territorio come chiave interpretativa delle trasformazioni occorse negli ultimi decenni in seguito all’intervento dell’Unione europea (UE), pur in assenza di competenza formale nei Trattati. Un’applicazione rigorosa e sistematica del concetto, mai tentata finora, è tra gli obiettivi del progetto di ricerca ESPON COMPASS (Comparative Analysis of Territorial Governance and Spatial Planning Systems in Europe), in cui gli autori del presente contributo sono stati parte attiva. Il contributo è volto a presentare parte degli esiti della ricerca che, in breve, mostra come l’Europeizzazione del governo del territorio non consista in un processo di convergenza verso un modello ideale, quanto piuttosto di trasformazione dei sistemi istituiti secondo logiche di mutuo adattamento e con esiti anche molto diversi. A tale processo concorrono le forme d’influenza “dall’alto” che l’UE esercita sugli Stati europei, quelle “dal basso” che gli Stati esercitano sulla UE ed infine le dinamiche d’influenza “orizzontale” tra gli Stati, favorite dall’azione dell’UE. Gli esiti attesi dalla ricerca sono raccomandazioni utili sia ad orientare la futura politica di coesione dell’UE, sia l’azione di governo del territorio negli Stati europei

Amino Acid and Biogenic Amine Composition of Busha Cattle Milk

To our knowledge, there is a lack of information on the nutrient composition of Busha cattle milk with special regard to its amino acid and biogenic amine contents. The Busha cattle breed is known to be highly resistant to various diseases and well-adapted to the extensive breeding conditions of the Balkan Peninsula. Busha cow milk contains an average of 13.47% dry matter, 4.34% fat, 3.72 % protein, and 4.32% lactose. Significant differences were detected (P < 0.05) in the amino acid compositions of the milk of different Busha cattle strains of Kosovo. Glutamic acid, proline, leucine, aspartic acid, lysine, and valine represented 68% of the total amino acid content. Essential amino acids, branched-chain and sulphur-containing amino acids were found in substantial amounts in the milk samples. Among the biogenic amines, however, spermine (0.16 mg kg1) and cadaverine (0.09 mg kg1) were present in low concentrations. Due to these excellent qualities of the Busha cow milk, preservation of this cattle breed is of great importance. Developing sustainable and secured breeding and feeding programs for this endangered cattle breed of the Balkan Peninsula should also be a high priority

FOS Expression in Osteoid Osteoma and Osteoblastoma: A Valuable Ancillary Diagnostic Tool

Osteoblastoma and osteoid osteoma together are the most frequent benign bone-forming tumor, arbitrarily separated by size. In some instances, it can be difficult to differentiate osteoblastoma from osteosarcoma. Following our recent description of FOS gene rearrangement in these tumors, the aim of this study is to evaluate the value of immunohistochemistry in osteoid osteoma, osteoblastoma, and osteosarcoma for diagnostic purposes. A total of 337 cases were tested with antibodies against c-FOS: 84 osteoblastomas, 33 osteoid osteomas, 215 osteosarcomas, and 5 samples of reactive new bone formation. In all, 83% of osteoblastomas and 73% of osteoid osteoma showed significant expression of c-FOS in the osteoblastic tumor cell component. Of the osteosarcomas, 14% showed c-FOS expression, usually focal, and in areas with severe morphologic atypia which were unequivocally malignant: 4% showed more conspicuous expression, but these were negative for FOS gene rearrangement. We conclude that c-FOS immunoreactivity is present in the vast majority of osteoblastoma/osteoid osteoma, whereas its expression is usually focal or patchy, in no more than 14% of osteosarcoma biopsies. Therefore, any bone-forming tumor cases with worrying histologic features would benefit from fluorescence in situ hybridization analysis for FOS gene rearrangement. Our findings highlight the importance of undertaking a thorough assessment of expression patterns of antibodies in the light of morphologic, clinical, and radiologic features

Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement

A fusion between fibronectin 1 (FN1) and activin receptor 2A (ACVR2A) has been reported previously in isolated cases of the synovial chondromatosis. To analyze further and validate the findings, we performed FISH and demonstrated recurrent FN1-ACVR2A rearrangements in synovial chondromatosis (57%), and chondrosarcoma secondary to synovial chondromatosis (75%), showing that FN1 and/or AVCR2A gene rearrangements do not distinguish between benign and malignant synovial chondromatosis. RNA sequencing revealed the presence of the FN1-ACVR2A fusion in several cases that were negative by FISH suggesting that the true prevalence of this fusion is potentially higher than 57%. In soft tissue chondromas, FN1 alterations were detected by FISH in 50% of cases but no ACVR2A alterations were identified. RNA sequencing identified a fusion involving FN1 and fibroblast growth factor receptor 2 (FGFR2) in the case of soft tissue chondroma and FISH confirmed recurrent involvement of both FGFR1 and FGFR2. These fusions were present in a subset of soft tissue chondromas characterized by grungy calcification, a feature reminiscent of phosphaturic mesenchymal tumor. However, unlike the latter, fibroblast growth factor 23 (FGF23) mRNA expression was not elevated in soft tissue chondromas harboring the FN1-FGFR1 fusion. The mutual exclusivity of ACVR2A rearrangements observed in synovial chondromatosis and FGFR1/2 in soft tissue chondromas suggests these represent separate entities. There have been no reports of malignant soft tissue chondromas, therefore differentiating these lesions will potentially alter clinical management by allowing soft tissue chondromas to be managed more conservatively