HCN1 channels in cerebellar Purkinje cell promote late stages of learning and constrain synaptic inhibition

Abstract Neural computations rely on ion channels that modify neuronal responses to synaptic inputs. While single cell recordings suggest diverse and neurone type-specific computational functions for HCN1 channels, their behavioural roles in any single neurone type are not clear. Using a battery of behavioural assays, including analysis of motor learning in vestibulo-ocular reflex and rotarod tests, we find that deletion of HCN1 channels from cerebellar Purkinje cells selectively impairs late stages of motor learning. Because deletion of HCN1 modifies only a subset of behaviours involving Purkinje cells, we asked whether the channel also has functional specificity at a cellular level. We find that HCN1 channels in cerebellar Purkinje cells reduce the duration of inhibitory synaptic responses but, in the absence of membrane hyperpolarization, do not affect responses to excitatory inputs. Our results indicate that manipulation of subthreshold computation in a single neurone type causes specific modifications to behaviour. © 2013 The Physiological Society

Dataset_Barros_2021

Dataset of the manuscript entittled "Conservation of locomotion-induced oculomotor activity through evolution in higher tetrapods" by Filipa França de Barros, Julien Bacqué-Cazenave, Coralie Taillebuis, Gilles Courtand, Marin Manuel, Hélène Bras, Michele Tagliabue, Denis Combes , François Lambert, Mathieu Beranec

Schenberg et al. 2023

Data set corresponding to the preprint and eLife article:"Subchronic alteration of vestibular hair cells in mice: implications for multisensory gaze stabilization" ; doi: https://doi.org/10.1101/2023.04.19.535725doi: https://doi.org/10.7554/eLife.88819.1THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Dataset_Barros_2021

Dataset of the manuscript entittled "Conservation of locomotion-induced oculomotor activity through evolution in higher tetrapods" by Filipa França de Barros, Julien Bacqué-Cazenave, Coralie Taillebuis, Gilles Courtand, Marin Manuel, Hélène Bras, Michele Tagliabue, Denis Combes , François Lambert, Mathieu Beranec

Schenberg et al. 2023

Data set corresponding to the eLife article:"Multisensory gaze stabilization in response to subchronic alteration of vestibular type I hair cells" ; doi: https://doi.org/10.1101/2023.04.19.535725doi: https://doi.org/10.7554/eLife.88819.1THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Dataset_Barros_2020

Dataset of the manuscript entitled "Long term visuo-vestibular mismatch in freely behaving mice differentially affects gaze stabilizing reflexes" by Barros, Schenberg, Tagliabue, Beranec