Quantum electrodynamics of a free particle near dispersive dielectric or conducting boundaries

Quantum electrodynamics near a boundary is investigated by considering the inertial mass shift of an electron near a dielectric or conducting surface. We show that in all tractable cases the shift can be written in terms of integrals over the TE and TM reflection coefficients associated with the surface, in analogy to the Lifshitz formula for the Casimir effect. We discuss the applications and potential limitations of this formula, and provide exact results for several models of the surface

Using transonic small disturbance theory for predicting the aeroelastic stability of a flexible wind-tunnel model

The CAP-TSD (Computational Aeroelasticity Program - Transonic Small Disturbance) code, developed at the NASA - Langley Research Center, is applied to the Active Flexible Wing (AFW) wind tunnel model for prediction of the model's transonic aeroelastic behavior. Static aeroelastic solutions using CAP-TSD are computed. Dynamic (flutter) analyses are then performed as perturbations about the static aeroelastic deformations of the AFW. The accuracy of the static aeroelastic procedure is investigated by comparing analytical results to those from previous AFW wind tunnel experiments. Dynamic results are presented in the form of root loci at different Mach numbers for a heavy gas and air. The resultant flutter boundaries for both gases are also presented. The effects of viscous damping and angle-of-attack, on the flutter boundary in air, are presented as well

Transdermal Drug Permeation Enhancement Using Low Molecular Weight Primary Aliphatic Thiols

Current transdermal drug delivery systems are limited to delivery, via passive diffusion, of a few substances exhibiting natural skin penetrability. These substances are low molecular weight, highly potent agents possessing a certain degree of hydrophilicity as well as lipophilicity. These limitations are dictated by the outermost layer of the skin, the stratum corneum, which acts as a barrier. The stratum corneum consists mostly of the protein keratin. The barrier strength of keratin is attributed to its extensive disulfide bond cross-linking. In order to expand the spectrum of transdermal drug candidates this keratin barrier must be overcome. Low molecular weight primary aliphatic thiol compounds reduce disulfide linkages of cystine units in the keratin protein forming sulfhydryl-terminated cysteine units and thus diminishes the number of cross-links between polypeptide chains. This has been shown to increase the permeability of the skin to a variety of drugs by opening up the stratum corneum for facile diffusion most probably through increased diffusivity. This validates the use of low molecular weight primary aliphatic thiol compounds as transdermal permeation enhancers. One of the major requirements of any pharmaceutical applied topically is lack of significant irritation that would render the formulation unacceptable to the user. An acute non-invasive dermal toxicity study on both animals and humans has shown most of the enhancers to be well tolerated

Wing flutter calculations with the CAP-TSD unsteady transonic small disturbance program

The application and assessment is described of CAP-TSD (Computational Aeroelasticity Program - Transonic Small Disturbance) code for flutter prediction. The CAP-TSD program was developed for aeroelastic analysis of complete aircraft configurations and was previously applied to the calculation of steady and unsteady pressures. Flutter calculations are presented for two thin, swept-and-tapered wing planforms with well defined modal properties. The calculations are for Mach numbers from low subsonic to low supersonic values, including the transonic range, and are compared with subsonic linear theory and experimental flutter data. The CAP-TSD flutter results are generally in good agreement with the experimental values and are in good agreement with subsonic linear theory when wing thickness is neglected

Anomalous magnetic moment of an electron near a dispersive surface

Changes in the magnetic moment of an electron near a dielectric or conducting surface due to boundary-dependent radiative corrections are investigated. The electromagnetic field is quantized by normal mode expansion for a nondispersive dielectric and an undamped plasma, but the electron is described by the Dirac equation without matter-field quantization. Perturbation theory in the Dirac equation leads to a general formula for the magnetic-moment shift in terms of integrals over products of electromagnetic mode functions. In each of the models investigated, contour integration techniques over a complex wave vector can be used to derive a general formula featuring just integrals over transverse electric and transverse magnetic reflection coefficients of the surface. Analysis of the magnetic-moment shift for several classes of materials yields markedly different results from the previously considered simplistic “perfect-reflector” model, due to the inclusion of physically important features of the electromagnetic response of the surface such as evanescent field modes and dispersion in the material. For a general dispersive dielectric surface, the magnetic-moment shift of a nearby electron can exceed the previous prediction of the perfect-reflector model by several orders of magnitude

Environmental and cultural considerations for growth of potatoes in CELSS

The white potato (Solanum tuberosum) was evaluated for use in the Closed Ecology Life Support System (CELSS) because of its high ratio of edible to inedible biomass and highly nutritious tuber that consists of readily digestible carbohydrates and proteins. Results are given for conditions that will produce the highest yields. The results, given in tabluar form, indicate the optimum temperatures, irradiance, carbon dioxide concentration, root environment, plant spacing, root and stolen containment, and harvesting times

The Nature and Location of Quantum Information

Quantum information is defined by applying the concepts of ordinary (Shannon) information theory to a quantum sample space consisting of a single framework or consistent family. A classical analogy for a spin-half particle and other arguments show that the infinite amount of information needed to specify a precise vector in its Hilbert space is not a measure of the information carried by a quantum entity with a $d$-dimensional Hilbert space; the latter is, instead, bounded by log d bits (1 bit per qubit). The two bits of information transmitted in dense coding are located not in one but in the correlation between two qubits, consistent with this bound. A quantum channel can be thought of as a "structure" or collection of frameworks, and the physical location of the information in the individual frameworks can be used to identify the location of the channel. Analysis of a quantum circuit used as a model of teleportation shows that the location of the channel depends upon which structure is employed; for ordinary teleportation it is not (contrary to Deutsch and Hayden) present in the two bits resulting from the Bell-basis measurement, but in correlations of these with a distant qubit. In neither teleportation nor dense coding does information travel backwards in time, nor is it transmitted by nonlocal (superluminal) influences. It is (tentatively) proposed that all aspects of quantum information can in principle be understood in terms of the (basically classical) behavior of information in a particular framework, along with the framework dependence of this information.Comment: Latex 29 pages, uses PSTricks for figure

Characterization of the Active Site and Insight into the Binding Mode of the Anti-angiogenesis Agent Fumagillin to the Manganese(II)-Loaded Methionyl Aminopeptidase from \u3cem\u3eEscherichia coli\u3c/em\u3e

EPR spectra were recorded for methionine aminopeptidase from Escherichia coli (EcMetAP-I) samples (~2.5 mM) to which one and two equivalents of Mn(II) were added (the latter is referred to as [MnMn(EcMetAP-I)]). The spectra for each sample were indistinguishable except that the spectrum of [MnMn(EcMetAP-I)] was twice as intense. The EPR spectrum of [MnMn(EcMetAP-I)] exhibited the characteristic six-line g≈2 EPR signal of mononuclear Mn(II) with A av(55Mn)=9.3 mT (93 G) and exhibited Curie-law temperature dependence. This signal is typical of Mn(II) in a ligand sphere comprising oxygen and/or nitrogen atoms. Other features in the spectrum were observed only as the temperature was raised from that of liquid helium. The temperature dependences of these features are consistent with their assignment to excited state transitions in the S=1, 2 ... 5 non-Kramer’s doublets, due to two antiferromagnetically coupled Mn(II) ions with an S=0 ground state. This assignment is supported by the observation of a characteristic 4.5 mT hyperfine pattern, and by the presence of signals in the parallel mode consistent with a non-Kramers’ spin ladder. Upon the addition of the anti-angiogenesis agent fumagillin to [MnMn(EcMetAP-I)], very small changes were observed in the EPR spectrum. MALDI-TOF mass spectrometry indicated that fumagillin was, however, covalently coordinated to EcMetAP-I. Therefore, the inhibitory action of this anti-angiogenesis agent on EcMetAP-I appears to involve covalent binding to a polypeptide component at or near the active site rather than direct binding to the metal ions

Motion of the Zinc Ions in Catalysis by a Dizinc Metallo-β-Lactamase

We report rapid-freeze-quench X-ray absorption spectroscopy of a dizinc metallo-β-lactamase (MβL) reaction intermediate. The Zn(II) ions in the dinuclear active site of the S. maltophilia Class B3 MβL move away from each other, by ∼0.3 Å after 10 ms of reaction with nitrocefin, from 3.4 to 3.7 Å. Together with our previous characterization of the resting enzyme and its nitrocefin product complex, where the Zn(II) ion separation relaxes to 3.6 Å, these data indicate a scissoring motion of the active site that accompanies the ring-opening step. The average Zn(II) coordination number of 4.5 in the resting enzyme appears to be maintained throughout the reaction with nitrocefin. This is the first direct structural information available on early stage dizinc metallo-β-lactamase catalysis

Environmental economics and valuation: towards a practical investment framework for Catchment Management Authorities in New South Wales

The Catchment Management Authorities in New South Wales have programs that are collectively investing $436 million over four years to achieve catchment-wide natural resource/environmental improvements. In this paper, we consider the question of how to best allocate these resources so as to increase the well-being of the public within catchments and the state. We consider the current approaches used by CMAs and make a case for Benefit-Cost Analysis as an alternative means of assessing ex ante questions of priority setting at the catchment level and for project appraisal. A major issue for BCA is the estimation of potential benefits from project investments, particularly the estimation of values that catchment communities and those living outside the catchments place on the non-use benefits associated with environmental improvements. We discuss alternative means of eliciting such values and propose the stated-preference method of Choice Modelling as a means of overcoming this Benefit-Cost Analysis shortcoming, because it incorporates advances in non-market valuation.environmental, economics, choice modelling, non-use values, investment framework, Environmental Economics and Policy,