El efecto Raman

Tirada aparte de la revista ION. no. 262.Peer reviewe

Pasado, presente y futuro de la espectroscopia infrarroja

Es tirada aparte de la Revista ION, febrero, marzo de 1962Peer reviewe

Espectros de absorción infrarroja de la monometilamina, dimetilmanina y trimetilamina

Tesis inédita de la Universidad de Madrid, Facultad de Ciencias, leída en 1954Peer reviewe

Espectros: El efecto Raman

Peer reviewe

Synthesis, structural and conformational study of some esters derived from 3-methyl-3-azabicyclo[3.2.1]octan-8(α and β)-ols

6 pags.; 1 sch.; 4 tabs.A series of α and β-esters bearing a 3-methyl-3-azabicyclo[3.2.1]octane moiety as well as methyl and aryl substituents were synthesized and studied by 1H and 13C NMR spectroscopies. In CDCl3 solution, at room temperature, a chair-envelope conformation for the bicycle moiety with the N-CH3 group in equatorial position with respect to the chair ring is proposed for both, α and β-esters. The chair conformation of the piperidine ring is puckered at C8 in the α-epimers and it is flattened at N3, in the β-epimers. Free rotation of the acyloxy group around the C8O bond has also been deduced. Analgesic activity of four of these substances was studied. 8β-Benzoyloxy-3-methyl-3-azabicyclo[3.2.1]octane demonstrated significant analgesic activity in the hot plate test compared to morphine. By measuring the rectal temperature in mice, results also showed a significant antipyretic activity of this compound.The authors thank A. Madrid for the synthesis of the compounds. They also thank Dr. A. Orjales (FAES S.A. Laboratories, Bilbao, Spain) the pharmacological data.Peer Reviewe

Analysis of feline urinary calculi and urethral plugs by infrared spectroscopy and scanning electron microscopy

The chemical constituents of 34 feline urinary calculi and five urethral plugs were analysed by infrared spectroscopy. The analysis revealed that 18 (52.9 per cent) of the calculi contained magnesium ammonium phosphate hexahydrate (struvite) as the major component; 10 (29.4 per cent) contained complex ammonium urates (three of them also containing calcium phosphate, mainly on the surface); three were composed of calcium phosphates and three were composed mainly of calcium oxalate mono and dihydrates. The urethral plugs were composed primarily of struvite, but also contained large amounts of organic matter. The examination of 16 selected samples by scanning electron microscopy and electron dispersive x-ray analysis revealed that their crystalline structures were similar to those of canine stones

Infrared analysis of essential oils

Peer reviewe

Synthesis, structural, conformational and pharmacological study of some carbamates derived from 8-methyl-8-azabicyclo[3.2.1]octan-3α-ol

A series of benzimidazole, thiazole, and benzothiazole carbamates derived from 8-methyl-8-azabicyclo[3.2.1]octan-3α-ol hydrochloride was synthesized and studied by 1H, 13C NMR and IR spectroscopy. To assist in the interpretation of the spectroscopic data, the free bases were obtained and studied by IR spectroscopy in different media. As in related compounds, spectroscopic results showed that two different carbamates (1-carbamate or 2-carbamate) could be obtained in the case of the hydrochlorides of benzimidazole derivatives. The hydrochlorides studied displayed in DMSO-d 6 solution a preferred flattened chair-envelope conformation with the NCH3 substituent in an equatorial disposition. Pharmacological assays in vitro and in vivo were drawn to evaluate 5-HT3 activity. © 2011 Elsevier B.V. All rights reserved.The authors thank Dr. A. Orjales (FAES S.A. Laboratories, Bilbao, Spain) for the pharmacologicalstudies.Peer Reviewe

Synthesis, spectroscopic, structural and conformational study of some ureas derived from N-methylpiperazine

Trabajo presentado en el 31st European Congress on Molecular Spectroscopy (EUCMOS 2012), celebrado en Cluj-Napoca (Rumanía) del 26 al 31 de agosto de 201

Synthesis, spectroscopic, structural and conformational study of some tri-substituted ureas derived from N-methylpiperazine containing phenyl and N-heterocyclic substituents

A series of tri-substituted ureas containing an N-methylpiperazine moiety as well as phenyl and N-heterocyclic substituents were synthesized and studied by 1H, 13C NMR and IR spectroscopies. From 1H and 13C NMR data, in CDCl3 solution at room temperature, a fast inter-conversion of the piperazine ring with the N-CH3 group in equatorial position can be proposed. Amino–imino tautomerism is observed for both thiazole and benzothiazole derivatives. Moreover, with the exception of the imino form of the thiazole derivative, the aryl substituted N-carbamoyl group rotates freely. IR data show that the compounds adopt a planar trans conformation of the single bondCOsingle bondNHsingle bond moiety