13,021 research outputs found
Prostate Biopsy Assistance System with Gland Deformation Estimation for Enhanced Precision
Computer-assisted prostate biopsies became a very active research area during
the last years. Prostate tracking makes it possi- ble to overcome several
drawbacks of the current standard transrectal ultrasound (TRUS) biopsy
procedure, namely the insufficient targeting accuracy which may lead to a
biopsy distribution of poor quality, the very approximate knowledge about the
actual location of the sampled tissues which makes it difficult to implement
focal therapy strategies based on biopsy results, and finally the difficulty to
precisely reach non-ultrasound (US) targets stemming from different modalities,
statistical atlases or previous biopsy series. The prostate tracking systems
presented so far are limited to rigid transformation tracking. However, the
gland can get considerably deformed during the intervention because of US probe
pres- sure and patient movements. We propose to use 3D US combined with
image-based elastic registration to estimate these deformations. A fast elastic
registration algorithm that copes with the frequently occurring US shadows is
presented. A patient cohort study was performed, which yielded a statistically
significant in-vivo accuracy of 0.83+-0.54mm.Comment: This version of the paper integrates a correction concerning the
local similarity measure w.r.t. the proceedings (this typing error could not
be corrected before editing the proceedings
Desensitizing Inflation from the Planck Scale
A new mechanism to control Planck-scale corrections to the inflationary eta
parameter is proposed. A common approach to the eta problem is to impose a
shift symmetry on the inflaton field. However, this symmetry has to remain
unbroken by Planck-scale effects, which is a rather strong requirement on
possible ultraviolet completions of the theory. In this paper, we show that the
breaking of the shift symmetry by Planck-scale corrections can be
systematically suppressed if the inflaton field interacts with a conformal
sector. The inflaton then receives an anomalous dimension in the conformal
field theory, which leads to sequestering of all dangerous high-energy
corrections. We analyze a number of models where the mechanism can be seen in
action. In our most detailed example we compute the exact anomalous dimensions
via a-maximization and show that the eta problem can be solved using only
weakly-coupled physics.Comment: 34 pages, 3 figures
Simple threshold rules solve explore/exploit tradeâoffs in a resource accumulation search task
How, and how well, do people switch between exploration and exploitation to search for and accumulate resources? We study the decision processes underlying such exploration/exploitation tradeâoffs using a novel card selection task that captures the common situation of searching among multiple resources (e.g., jobs) that can be exploited without depleting. With experience, participants learn to switch appropriately between exploration and exploitation and approach optimal performance. We model participants' behavior on this task with random, threshold, and sampling strategies, and find that a linear decreasing threshold rule best fits participants' results. Further evidence that participants use decreasing thresholdâbased strategies comes from reaction time differences between exploration and exploitation; however, participants themselves report nonâdecreasing thresholds. Decreasing threshold strategies that âfrontâloadâ exploration and switch quickly to exploitation are particularly effective in resource accumulation tasks, in contrast to optimal stopping problems like the Secretary Problem requiring longer exploration
Universality in D-brane Inflation
We study the six-field dynamics of D3-brane inflation for a general scalar
potential on the conifold, finding simple, universal behavior. We numerically
evolve the equations of motion for an ensemble of more than 7 \times 10^7
realizations, drawing the coefficients in the scalar potential from statistical
distributions whose detailed properties have demonstrably small effects on our
results. When prolonged inflation occurs, it has a characteristic form: the
D3-brane initially moves rapidly in the angular directions, spirals down to an
inflection point in the potential, and settles into single-field inflation. The
probability of N_{e} e-folds of inflation is a power law, P(N_{e}) \propto
N_{e}^{-3}, and we derive the same exponent from a simple analytical model. The
success of inflation is relatively insensitive to the initial conditions: we
find attractor behavior in the angular directions, and the D3-brane can begin
far above the inflection point without overshooting. In favorable regions of
the parameter space, models yielding 60 e-folds of expansion arise
approximately once in 10^3 trials. Realizations that are effectively
single-field and give rise to a primordial spectrum of fluctuations consistent
with WMAP, for which at least 120 e-folds are required, arise approximately
once in 10^5 trials. The emergence of robust predictions from a six-field
potential with hundreds of terms invites an analytic approach to multifield
inflation.Comment: 28 pages, 9 figure
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