TRANSPORT INFRASTRUCTURE AS PART OF TOURISM DEVELOPMENT

Transport, as a large intersectoral complex, has features similar to tourism, and can develop successfully only with effective management of related industries. Tourism transport infrastructure includes tourism and transport industries, and all three areas interact with each other.Транспорт, как крупный межотраслевой комплекс, имеет черты, аналогичные туризму, и может успешно развиваться только при эффективном управлении смежными отраслями. Транспортная инфраструктура туризма включает туристическую и транспортную отрасль, и все три области взаимодействуют друг с другом

Development of Vertical Scaffolding Construction

We live in the age of the latest information technologies, brilliant scientific discoveries, and really large megacities with a million people. Due to the accelerated industrialization and population growth, the ecology of cities is seriously affected. Each metropolis is looking for its own solutions to this problem and implements them, for example, by landscaping the city, including growing plants on the roofs and walls of buildings, and creating "vertical forests".Мы живем в век новейших информационных технологий, блестящих научных открытий и действительно больших мегаполисов с миллионным населением. Из-за ускоренной индустриализации и роста населения серьезно страдает экология городов. Каждый мегаполис ищет собственные решения этой проблемы и реализует их, например, озеленением города, включая выращивание растений на крышах и стенах зданий и создание «вертикальных лесов»

Cell-Free DNA Plasma Levels Differ in Age-Specific Pattern in Healthy Rats and Castrates with Testosterone-Induced Benign Prostatic Hyperplasia

The purpose of this work was to study changes in the level of cell-free DNA (cfDNA) in the blood of young and old rats in the normal state and with induced benign prostatic hyperplasia (BPH). Male Wistar rats were divided into 4 groups—young (3 months), old (20 months), intact, or with testosterone-induced BPH. Groups with BPH were subjected to surgical castration and administration of testosterone esters at a dose of 25 mg/kg for a total of 7 injections for 20 days. In intact animals, the level of cfDNA in old rats (2.00±0.14 ng/μl) was significantly higher than that in the young (1.02±0.30 ng/μl). The body and the prostate weights of old rats were 1.6 and 1.4 times larger than those of the young, without an increase in the prostate index (PI). The testosterone level in the blood of young rats was 1.6 times higher than that of old (6.20±0.93 nmol/l vs. 3.77±0.55 nmol/l; NS). In animals with BPH, the level of cfDNA in old rats (3.14±0.76 ng/μl) was significantly higher than that in young rats (0.80±0.14 ng/μl). The body and the prostate weights in old rats were 1.8 and 2.3 times larger, than those in young rats, with an increase in the PI. The level of testosterone in the blood of young (15.76±0.51 nmol/l) and old (16.99±1.1 nmol/l) rats was not significantly different. Morphological signs of BPH were observed in the prostate of both young and old rats. During the induction of BPH in the experiment, according to the level of cfDNA, cell death processes have not changed significantly in young rats but significantly increased in old rats. A similar trend was observed in the group of intact animals. The obtained data indicate that apoptosis processes are enhanced during the development of BPH despite the growth of tissues in the prostate itself