Additional file 1 of Online prediction for respiratory movement compensation: a patient-specific gating control for MRI-guided radiotherapy

Additional file 1. Algorithmic steps for generating adaptive gating signals

Characteristics of the five SNPs.

<p>Characteristics of the five SNPs.</p

Kaplan-Meier estimated cumulative RP probability as a function of time from the start of RT by genotype of rs1801131.

<p>GG/GT genotypes was associated with a lower risk of ≥ 2 RP (P = 0.002).</p

Patients demographics and associations with the risk of developing ≥ 2 RP (n = 265).

<p>Patients demographics and associations with the risk of developing ≥ 2 RP (n = 265).</p

Kaplan-Meier estimated the effect of genotype of rs1801131 and dosimetric parameters on cumulative RP probability.

<p>(A) Patients with TT genotype of rs1801131 and MLD >11.6Gy had higher risk of ≥ 2 RP compared with GG/GT genotypes (P<0.001). (B) Patients with TT genotype of rs1801131 and V20 >17.1% had higher risk of ≥ 2 RP compared with GG/GT genotypes(P<0.001).</p

Associations between genotypes and the risk of developing ≥ 2 RP.

<p>Associations between genotypes and the risk of developing ≥ 2 RP.</p

Brain Radiotherapy plus Concurrent Temozolomide versus Radiotherapy Alone for Patients with Brain Metastases: A Meta-Analysis

<div><p>Objective</p><p>We performed a meta-analysis of randomized clinical trials to compare the efficacy of brain radiotherapy (RT) combined with temozolomide (TMZ) versus RT alone as first-line treatment for brain metastases (BM).</p><p>Methods</p><p>Medline, Embase, and Pubmed were used to search for relevant randomized controlled trials (RCTs). Two investigators reviewed the abstracts and independently rated the quality of trials and relevant data. The primary outcome was overall survival (OS). Secondary outcomes included progression-free survival (PFS), objective response rate (ORR), and adverse events.</p><p>Results</p><p>Seven studies were selected from the literature search. RT plus TMZ produced significant improvement in ORR with odds ratio (OR) of 2.27 (95% CI, 1.29 to 4.00; <i>P</i> = 0.005) compared with RT alone. OS and PFS were not significantly different between the two arms (OS: HR, 1.00; <i>P</i> = 0.959; PFS: HR, 0.73; <i>P</i> = 0.232). However, the RT plus TMZ arm was associated with significantly more grade 3 to 4 nausea and thrombocytopenia.</p><p>Conclusion</p><p>Concomitant RT and TMZ, compared to RT alone, significantly increases ORR in patients with BM, but yields increased toxicity and fails to demonstrate a survival advantage.</p></div

Additional file 2: Table S1. of Involved field radiotherapy (IFRT) versus elective nodal irradiation (ENI) for locally advanced non-small cell lung cancer: a meta-analysis of incidence of elective nodal failure (ENF)

Quality assessment of cohort studies using the Newcastle–Ottawa scale. (DOC 26 kb

Forest plot of subgroup analysis by cancer type for OS.

<p>Forest plot of subgroup analysis by cancer type for OS.</p

N‑Heterocyclic Carbene-Catalyzed δ‑Carbon LUMO Activation of Unsaturated Aldehydes

An N-heterocyclic carbene (NHC) catalyzed domino reaction triggered by a δ-LUMO activation of α,β–γ,δ-diunsaturated enal has been developed for the formal [4 + 2] construction of multisubstituted arenes and 3-ylidenephthalide. These two products, formed in a highly chemo- and regioselective manner, were obtained via different catalytic pathways due to a simple change of the substrate. The activation of the remote δ-carbon of unsaturated aldehydes expands the synthetic potentials of NHC organocatalysis