Additional file 5: Figure S2. of miR-539 inhibits prostate cancer progression by directly targeting SPAG5

miR-539 is downexpressed in primary PCa and metastatic PCa. miR-539 level was gradually decreased in normal prostate, primary PCa, and metastatic PCa samples. (JPG 173 kb

Additional file 2: Table S2. of miR-539 inhibits prostate cancer progression by directly targeting SPAG5

Prognostic value of SPAG5 protein expression for the biochemical recurrence free survival in univariate and multivariate analyses by Cox regression. (DOC 34 kb

Additional file 3: Table S3. of miR-539 inhibits prostate cancer progression by directly targeting SPAG5

Prognostic value of SPAG5 protein expression for the overall survival in univariate and multivariate analyses by Cox regression. (DOC 34 kb

Additional file 4: Figure S1. of miR-539 inhibits prostate cancer progression by directly targeting SPAG5

miR-539 inhibits PCa cell proliferation, migration and invasion by targeting SPAG5 in vitro. A, Ectopic expression of miR-539 can mimic the suppression of colony formation induced by SPAG5 knockdown in PC-3 and LNCaP cells; B, Ectopic expression of miR-539 can mimic the suppression of migration activity induced by SPAG5 knockdown in PC-3 and LNCaP cells; C, Ectopic expression of miR-539 can mimic the suppression of invasion activity induced by SPAG5 knockdown in PC-3 and LNCaP cells; D, The efficiency of SPAG5 knockdown and ectopic expression of miR-539 was confirmed at protein level by western blot. (JPG 145 kb