24 research outputs found

    Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

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    Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

    Search for a Heavy Particle Decaying into an Electron and a Muon with the ATLAS Detector in root s=7 TeV pp collisions at the LHC

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    Search for a Standard Model Higgs Boson in the H -> ZZ -> l(+)l(-)v(v)over-bar Decay Channel with the ATLAS Detector

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    Search for contact interactions in dimuon events from pp collisions at root s=7 TeV with the ATLAS detector

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    Measurement of underlying event characteristics using charged particles in pp collisions at root s = 900 GeV and 7 TeV with the ATLAS detector

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    Study of jet shapes in inclusive jet production in pp collisions at root s=7 TeV using the ATLAS detector

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    Search for pair production of first or second generation leptoquarks in proton-proton collisions at root s=7 TeV using the ATLAS detector at the LHC

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    Measurement of the inclusive isolated prompt photon cross section in pp collisions at root s=7 TeV with the ATLAS detector

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    Measurement of W gamma and Z gamma production in proton-proton collisions at root s=7 TeV with the ATLAS detector

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    Search for supersymmetric particles in events with lepton pairs and large missing transverse momentum in root s=7 TeV proton-proton collisions with the ATLAS experiment

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