6 research outputs found
Determinants of Disuse-Induced Skeletal Muscle Atrophy: Exercise and Nutrition Countermeasures to Prevent Protein Loss
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- Adams GR Caiozzo VJ, Baldwin KM
- Adams GR McCue SA, Bodell PW, Zeng
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- Alkner BA Tesch PA
- Alkner BA Tesch PA
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- Anthony JC Lang CH, Crozier SJ, An
- Baar K Esser K
- Babij P Booth FW
- Baker JH Margolis RN
- Baldwin KM Haddad F
- Baldwin KM Herrick RE, McCue SA
- Berg HE Tesch PA
- Bey L Akunuri N, Zhao P, Hoffman E
- Bey L Hamilton MT
- Bianchi G Marzocchi R, Agostini F,
- Blomstrand E Eliasson J, Karlsson
- Booth FW
- Booth FW Criswell DS
- Caiozzo VJ Baker MJ, McCue SA, Bal
- Caiozzo VJ Haddad F, Baker MJ, Her
- Carroll CC Fluckey JD, Williams RH
- Chen YW Nader GA, Baar KR, Fedele
- Childs TE Spangenburg EE, Vyas DR,
- Criswell DS Booth FW, DeMayo F, Sc
- D'Aunno DS Robinson RR, Smith
- Dodd SL Koesterer TJ
- Dupont-Versteegden EE Houle JD, Gu
- Durham WJ Li YP, Gerken E, Farid M
- Edgerton VR Roy RR, Allen DL, Mont
- Ferrando AA Lane HW, Stuart CA, Da
- Ferrando AA Tipton KD, Bamman MM,
- Fitts RH Riley DR, Widrick JJ
- Fitts RH Riley DR, Widrick JJ
- Flü
- Fluckey JD Dupont-Versteegden EE,
- Fluckey JD Dupont-Versteegden EE,
- Fluckey JD Knox M, Smith LM, Dupon
- Gamrin L Berg HE, Essen P, Tesch P
- Glass DJ
- Glickman MH Ciechanover A
- Goldspink DF Garlick PJ, McNurlan
- Graham SC Roy RR, Hauschka EO, Edg
- Grichko VP Heywood-Cooksey A, Kidd
- Grigor'ev AI Shenkman BS, Bel
- Grindeland RE Roy RR, Edgerton VR,
- Haddad F Baldwin KM, Tesch PA
- Haddad F Roy RR, Zhong H, Edgerton
- Haddad F Roy RR, Zhong H, Edgerton
- Hauschka EO Roy RR, Edgerton VR
- Henriksen EJ Rodnick KJ, Mondon CE
- Herbison GJ Jaweed MM, Ditunno JF
- Hicke L Dunn R
- Hirose M Kaneki M, Sugita H, Yasuh
- Hornberger TA Hunter RB, Kandarian
- Howard G Steffen JM, Geoghegan TE
- Hunter RB Mitchell-Felton H, Essig
- Hunter RB Stevenson E, Koncarevic
- Ikemoto M Nikawa T, Takeda S, Wata
- Jaspers SR Fagan JM, Satarug S, Co
- Jaspers SR Fagan JM, Tischler ME
- Jaspers SR Tischler ME
- Kandarian SC Jackman RW
- Karlsson HK Nilsson PA, Nilsson J,
- Kasper CE White TP, Maxwell LC
- Kimball SR Farrell PA, Jefferson L
- Kimball SR Jefferson LS
- Kimball SR Jefferson LS
- Kimball SR Jefferson LS
- Kobayashi H Kato H, Hirabayashi Y,
- Koesterer TJ Dodd SL, Powers S
- Krawiec BJ Frost RA, Vary TC, Jeff
- Laviano A Muscaritoli M, Cascino A
- Lee SW Dai G, Hu Z, Wang X, Du J,
- Leeuwenburgh C Gurley CM, Strotman
- Leonard JI Leach CS, Rambaut PC
- Linderman JK Gosselink KL, Booth F
- Litvinova KS Kozlovskaia IB, Nemir
- Loughna P Goldspink G, Goldspink D
- Loughna PT Goldspink DF, Goldspink
- Matuszczak Y Arbogast S, Reid MB
- Mondon CE Rodnick KJ, Dolkas CB, A
- Morris CA Morris LD, Kennedy AR, S
- Munoz KA Satarug S, Tischler ME
- Musacchia XJ Steffen JM, Fell RD
- Naito H Powers SK, Demirel HA, Sug
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- Nikawa T Ishidoh K, Hirasaka K, Is
- Ohira Y Yoshinaga T, Nomura T, Kaw
- Ohira Y Yoshinaga T, Ohara M, Nona
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- Ohnishi T Wang X, Fukuda S, Takaha
- Paddon-Jones D Sheffield-Moore M,
- Paddon-Jones D Sheffield-Moore M,
- Parkington JD LeBrasseur NK, Siebe
- Patterson GT Dettbarn WD
- Reznick AZ Menashe O, Bar-Shai M,
- Riley DA Bain JL, Romatowski JG, F
- Riley DA Bain JL, Thompson JL, Fit
- Riley DA Bain JL, Thompson JL, Fit
- Riley DA Slocum GR, Bain JL, Sedla
- Roy RR Baldwin KM, Edgerton VR
- Sartorelli V Fulco M
- Schulte LM Navarro J, Kandarian SC
- Selsby JT Dodd SL
- Shah OJ Anthony JC, Kimball SR, Je
- Shangraw RE Stuart CA, Prince MJ,
- Shimomura Y Honda T, Shiraki M, Mu
- Shimomura Y Yamamoto Y, Bajotto G,
- Siu PM Alway SE
- St Pierre BA Tidball JG
- St-Amand J Okamura K, Matsumoto K,
- Steffen JM Fell RD, Geoghegan TE,
- Steffen JM Musacchia XJ
- Stein TP
- Stein TP Donaldson MR, Leskiw MJ,
- Stein TP Leskiw MJ, Schluter MD
- Stein TP Schluter MD
- Stein TP Schluter MD
- Stevenson EJ Giresi PG, Koncarevic
- Stuart CA Shangraw RE, Peters EJ,
- Stuart CA Shangraw RE, Prince MJ,
- Sugiura T Abe N, Nagano M, Goto K,
- TADA O
- Taillandier D Bigard X, Desplanche
- Tesch PA Ekberg A, Lindquist DM, T
- Thomason DB Biggs RB, Booth FW
- Thomason DB Herrick RE, Surdyka D,
- Tischler ME
- Tischler ME Satarug S, Eisenfeld S
- Tobin BW Uchakin PN, Leeper-Woodfo
- Vermaelen M Marini JF, Chopard A,
- Vijayan K Thompson JL, Norenberg K
- Whedon GD Lutwak L, Rambaut PC, Wh
- Widrick JJ Knuth ST, Norenberg KM,
- Witzmann FA Kim DH, Fitts RH
- Yimlamai T Dodd SL, Borst SE, Park
- YOKOGOSHI H
- Yokota H Sun HB, Malacinski GM
- YOSHIZAWA F
- Zdanowicz MM Teichberg S
- Zhang LF Sun B, Cao XS, Liu C, Yu
- Zhou MY Klitgaard H, Saltin B, Roy
- Publication venue
- 'Center for Academic Publications Japan'
- Publication date
- 01/01/2006
- Field of study
mTOR signaling in proteostasis and its relevance to autism spectrum disorders
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- An JJ Gharami K, Liao GY, et al.
- Bingol B Schuman EM
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- Doyle M Kiebler MA
- Epi4K Consortium Epilepsy Phenome/Genome Project
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2017
- Field of study
Proteins are extremely labile cellular components, especially at physiological temperatures. The appropriate regulation of protein levels, or proteostasis, is essential for all cells. In the case of highly polarized cells like neurons, proteostasis is also crucial at synapses, where quick confined changes in protein composition occur to support synaptic activity and plasticity. The accurate regulation of those cellular processes controlling protein synthesis and degradation is necessary for proteostasis, and its deregulation has deleterious consequences in brain function. Alterations in those cellular mechanisms supporting synaptic protein homeostasis have been pinpointed in autism spectrum disorders such as tuberous sclerosis, neurofibromatosis 1, PTEN-related disorders, fragile X syndrome, MECP2 disorders and Angelman syndrome. Proteostasis alterations in these disorders share the alterations in mechanistic/mammalian target of rapamycin (mTOR) signaling pathway, an intracellular pathway with key synaptic roles. The aim of the present review is to describe the recent literature on the major cellular mechanisms involved in proteostasis regulation in the synaptic context, and its association with mTOR signaling deregulations in various autism spectrum disorders. Altogether, the cellular and molecular mechanisms in synaptic proteostasis could be the foundation for novel shared therapeutic strategies that would take advantage of targeting common disorder mechanisms.This review was supported by grant BFU2015-68568-P (MINECO/FEDER, EU) to AO
Platinum-Group Metals, Alloys and Compounds in Catalysis
- Author
- A Borodzinski
- A Borodzinski
- A Farkas
- A Frackiewicz
- A Furst
- A Harriman
- A Nakamura
- A Nidola
- A Ofner
- A Onopchenko
- A Prince
- A Prince
- A Sieverts
- A Wheeler
- AA Grinberg
- AA Grinberg
- AA Grinberg
- AA Siddiqi
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Fasman
- AB Stiles
- ACL Su
- AD Ketley
- AD Ketley
- AD Semenova
- AD Semenova
- AD Semenova
- AD Semenova
- AD Westland
- ADF Toy
- AE Heywood
- AE Rea
- AE Shilov
- AER Budd
- AF Diwell
- AF Diwell
- AF Diwell
- AF Wells
- AF Wells
- AG Burden
- AG Knapton
- AG Oblad
- AH Janowicz
- AJ Appleby
- AJ Birch
- AJ Bird
- AJ Bird
- AJ Bird
- AJ Canale
- AJ Chalk
- AJ Haagen-Smit
- AJB Robertson
- AJB Robertson
- AK Holliday
- AK Holliday
- AL Wilds
- AM Feltham
- AM Taber
- AM Taber
- AM Taber
- AM Taber
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- AN Mal’tsev
- AN Mal’tsev
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- AN Mal’tsev
- AR Miedema
- AR Miedema
- AS Al-Ammor
- AS Arifulin
- AS Berezhnoi
- AT Gwathmey
- AU Rahman
- AV Shashkina
- AV Shashkina
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- AW Holmes
- AW Johnson
- AW Maverick
- AW Middleton
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1985
- Field of study
Chemical Modification and Cleavage of Proteins and Chemical Strategy in Immunochemical Studies of Proteins
- Author
- A Azzi
- A Bakardjieva
- A Caputo
- A Cerami
- A Dutton
- A Fontana
- A Fontana
- A Holmgren
- A Kotaki
- A Light
- A Makriyannis
- A Marzotto
- A Matsushima
- A Matsushima
- A Muhlard
- A Nisonoff
- A Nureddin
- A Patchornik
- A Patchornik
- A Patchornik
- A Patchornik
- A Patchornik
- A Patchornik
- A Patchornik
- A Pihl
- A Pocker
- A Previero
- A Previero
- A Previero
- A Previero
- A Previero
- A Previero
- A Previero
- A Ray
- A Reiss
- A Ruoho
- A Schejter
- A Schoberl
- A Shafferman
- A Shimizu
- A Signor
- A Signor
- A Takenaka
- A Takenaka
- A. Bollen
- AA Aboderin
- AD Barksdale
- AD Gounaris
- ADB Malcolm
- AE Bolton
- AF Bradbury
- AF Rosenthal
- AF Schick
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- AFSA Habeeb
- AFSA Habeeb
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- AG Plaut
- AG Weeds
- AH Coons
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- AH Neims
- AJ Birch
- AJ Brake
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- AJ Furth
- AJ Parker
- AK Balls
- AK Paterson
- AL Grossberg
- AL Grossberg
- AM Boussioux
- AM Crestfield
- AM Nigen
- AS Brill
- AS Inglis
- AS Keston
- AS McFarlane
- B Bak
- B Bizzini
- B Chesebro
- B Schmall
- B Witkop
- B Witkop
- BA Humphries
- BBL Agrawal
- BF Erlanger
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- BH Nicolet
- BJ Bowden
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- C Degani
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- Z Bohak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1977
- Field of study
Serious Asthma Events with Fluticasone plus Salmeterol versus Fluticasone Alone
- Author
- Abalos-Galito M
- Abboy C
- Abrahamian F
- Abreu E
- Ackerman If
- Acosta Ia
- Adams L
- Adaoag Aa
- Adiaz-Baui Tt
- Aggarwal Nk
- Aguilar Dominguez Pe
- Aguilar-Orozco Ra
- Aguirre Sosa I
- Ahmed M
- Aleksandrova E
- Alekseeva E
- Alexandrescu Ds
- Ali Mi
- Allen GG Jr
- Allen Dr
- Allison Dc
- Altieri Hh
- Alvey Jc
- Alwine Lk
- Amer L
- Anand S
- Andrasofszky Z
- Anspach Rb
- Antuni Jd
- Antépara Ercoreca I
- Anwar J
- Apaliski Sj
- Arastu Rs
- Aries Sp
- Arimah C
- Arnedillo Muñoz A
- Arora Cm
- Arthur Cp
- Asherova I
- Auerbach D
- Austri Investigators
- Azzam Sj
- Babyesiza A
- Backer V
- Badar FL 3rd
- Badat A
- Baker Jw
- Balakrishnan K
- Balthazar Y
- Banovcin P
- Barasch Jp
- Barbarash Ol
- Barbe Illa F
- Barber Ma
- Bardin Pg
- Bardinas-Rodriguez R
- Barnes Nc
- Barreiro López B
- Barreiro Tj
- Barros Monge Mj
- Barth D
- Bartha A
- Bartuzi Z
- Bassa A
- Bauler A
- Baumbach Rr
- Baur Ce
- Baxter Bs
- Beach Jl
- Beasley Rl
- Beavins Je
- Beliveau Wj
- Benbow Mj
- Benedix A
- Bennett Nl
- Bennett Rl
- Berenfus Vi
- Berg P
- Bergna Ma
- Bergtholdt B
- Bernal H
- Bernan Ap
- Bernstein Di
- Besh L
- Bettig U
- Bielous-Wilk A
- bin Abdul Aziz Fa
- Bindig Hw
- Blaiss Ms
- Blanco Aparicio M
- Blumenthal Kw
- Boada Valmaseda A
- Boas Sr
- Bolivar Grimaldos F
- Bolliger Ct
- Bonavia M
- Borders Jl
- Boscia Ja
- Bosque García M
- Botzen U
- Boulware Wn
- Bowling Bt
- Bożek A
- Brabec Ba
- Braga M
- Bramlet Dg
- Brautigam Df
- Breedt J
- Brehler R
- Breyer Go
- Brown V
- Brownell Jm
- Bruce Tr
- Bruckhaus-Walter M
- Bruning A
- Brzostek J
- Buaron Ks
- Bugrova O
- Bukreeva Eb
- Buresova M
- Burhan H
- Bursova J
- Bustamante Ruiz A
- Butkovic-Tomljanovic R
- Błażowski Ł
- Call Rs
- Calvo Gil Ma
- Campbell Ca
- Canaan Ya
- Cannon Df
- Carpio Jm
- Carretero Anibarro P
- Carroll Pa
- Castillo Hofer Cr
- Cathcart Ws
- Cerveri I
- Cevallos Jp
- Chapman Kr
- Chaudhuri R
- Chauhan Av
- Cheng Sl
- Chermenskiy A
- Chern Jh
- Chetta Aa
- Chevalier D
- Chiu Mh
- Chizhova O
- Choi I
- Chomiciene A
- Chorostowska-Wynimko J
- Christensen J
- Christensen Ta
- Christina Mo
- Chrzanowski Rr
- Chuang Rb
- Chung Cl
- Ciekalska K
- Cieslicki J
- Cirule I
- Cisneros Am
- Civitarese Fa
- Clark Jp
- Clements Bs
- Clifford Dp
- Coggi Ja
- Cohen Kr
- Collier D
- Collins Bg
- Collins H
- Comellas A
- Condit J
- Cordasco EM Jr
- Corder Cn
- Covar Ra
- Coverston Kd
- Crimi N
- Croce Sa
- Cruz H
- Csanadi Ma
- Cuadrado Ja
- Curtis Ct
- Cutrera R
- Daftary Pk
- Dalan D
- Dalawari Sp
- Daly Wc
- Dapper T
- Daud M
- Davies Ej
- Davis Kc
- Davoliene I
- Dawes Kw
- De Gennaro Ms
- De Rosa M
- De Valle Ol
- Decotiis Ba
- Del Campo Matias F
- Deluca Rf
- Demko I
- Desantis Dm
- Dhillon R
- Diaz Amor Pv
- Diaz Jd
- Diaz Jl
- Dice Jp
- Dimitrova R
- Dimova D
- Diogo Jj
- Dixon C
- Djajalaksana S
- Dobkin La
- Dobrusin Rs
- Dopudja Pantic V
- Dore Nd
- Dransfield Mt
- Dudnyk O
- Duka Kd
- Dupont Lj
- Ebbeling Wl
- Echave-Sustaet Jm
- Eckhard Jg
- Edwards Jd
- Eglite R
- Elacion Jm
- Elizalde A
- Elkayam D
- Ellery A
- Ellis Gc
- Ellison Wt
- Elsen Jr
- Emanuel S
- Emeryk A
- Emmett Ah
- Engel Lr
- Engelhard R
- Ensz Dj
- Ericksen Cl
- Ervin Je
- Espinosa de los Monteros Garde Mj
- Esposito S
- Estrella Viladegut Ra
- Evdokimova A
- Fang C
- Farkas M
- Farrah Vb
- Fazio Lizandrelo Cl
- Feldmeyer F
- Field Jd
- Figueroa Dp
- Fishman Hj
- Fissan H
- Fitzgerald Da
- Florea R
- Focauld F
- Focil A
- Folcik K
- Foresi A
- Forstner B
- Fouche Lf
- Franco MA Jr
- Frandsen Br
- Franz Kh
- Fratrik J
- Frick Bs
- Fulat Ma
- Funck J
- Fushtey Im
- Gammeri E
- Gani M
- Ganti K
- Garcia Hernandez Gm
- Garcia Fl
- Garmash N
- Garscadden Ag
- Garza-Salinas S
- Gatti Ea
- Gattolin G
- Gawlik R
- Gałuszka-Bilińska A
- Gellady Am
- George Ar
- Gessner Cm
- Gibbon Gw
- Giejlo M
- Ginko T
- Giorgadze Ml
- Gleason Gp
- Godlevska O
- Goldberg P
- Goldstein Mf
- Gonzalez Ge
- Gosn Am
- Gower Rg
- Grande Ja
- Gregory D
- Grigat Ce
- Grigoryev S
- Grimm-Sachs V
- Griskeviciene V
- Groth G
- Grubb Sd
- Guthrie Rp
- Guttlerova E
- Gömöri K
- Haas Ta
- Haft Ks
- Hajal R
- Hamelmann E
- Hammond Gd
- Hampf J
- Hanf G
- Hansel Nn
- Hansen Vr
- Harat R
- Harris Af
- Hartman An
- Hartman P
- Harvey Rr
- Havasi-Jost G
- Hazan-Steinberg S
- Headley Dm
- Hegedus-Jungvirth M
- Heigerick Gc
- Heinz Gu
- Heller Bn
- Helm K
- Hendrix El
- Henein S
- Herrod Jn
- Hewitt Mj
- Hines Rl
- Hirdt Ap
- Hirschfield Ja
- Hoeltz S
- Hoffman Ks
- Hofman T
- Hofmann S
- Hogan Ad
- Horvathova H
- Hosler Mr
- Hospodarskyy I
- Howland Wc
- Hsu Cc
- Hsu Fj
- Hubbard Wm
- Hudson Jd
- Huffman C
- Hussain M
- Iashyna L
- Idrisova E
- Iemoli E
- Ioachimescu Oc
- Irkhina I
- Ismail Ai
- Ismail Ms
- Ismail Ym
- Ivkovic-Jurekovic I
- Jaffrani Na
- Jahnz-Różyk K
- Jander R
- Jandl M
- Jasch-Hoppe B
- Jedrzejczak M
- Jiang N
- Jirmanova I
- Johnsen Cr
- Jones Sw
- Jordan Rs
- Joshi Ke
- Jung T
- Junggeburth Jj
- Jurgens Jc
- Kaashmiri Mw
- Kachel T
- Kaik G
- Kaladze M
- Kalafer M
- Kalina P
- Kamdar Ba
- Kamiński D
- Kanuga Jg
- Kao Nl
- Karako P Sr
- Kardos P
- Karetzky M
- Katsetos Jc
- Kay Js
- Kelly Aj
- Kelm Warchol A
- Khurkhurova Nv
- Khvelos Si
- Kim C
- Kim Js
- Kim Wj
- Kimmel Ma
- Kimura Sh
- Kingsley Jk
- Kirstein Jl
- Kis S
- Kissyova Ibrishimova G
- Kleerup Ec
- Klein Rm
- Knueppel W
- Koch T
- Koeberl Gh
- Koh Dw
- Koh Yy
- Kohli N
- Kolman P
- Kolorz C
- Kondyurina Eg
- Konieczny Z
- Korduan M
- Korth-Wiemann B
- Kostin Vi
- Kostromina Vp
- Koura Fa
- Kovacs Sp
- Krakhmalova O
- Kral Km
- Krasko Mp
- Kratzer J
- Kreit Ci
- Kreutter Fm
- Krezdorn Hg
- Kroker A
- Kruell M
- Kryuchko T
- Kubicki Tm
- Kucera M
- Kudelya L
- Kuehne P
- Kulynych Ov
- Kwasniewski A
- Kwok S
- Kwon Ss
- Labuda Jm
- Lai Rs
- Laleko Sl
- Lam As
- Lapidus Rj
- Lara Mm
- Larrateguy Ld
- Latorre Aj
- Lechin Ae
- Lee Jj
- Lee Md
- Lee S
- Lee Sh
- Lee Sk
- Lee Wm
- Legnani Dl
- Lenk U
- Lenney W
- Lenskaya L
- Lentnek Al
- Lenz Jj
- Lesh Kw
- Leszczyński W
- Levashov S
- Levchenko O
- Levins Pf
- Levinsky Dm
- Lezana Soya V
- Liefring E
- Liem Jj
- Lillestol Mj
- Lim H
- Lin Ck
- Litvinova T
- Liu Yc
- Livezey Md
- Lloyd-Turney Cw
- Loboshka Becheva M
- Lockey Rf
- Logvinenko N
- Long Ra
- Lores Obradors L
- Lougheed Md
- Lowe Dw
- Luengo Planas Mt
- Luisetti M
- Lynch Mj
- López Viña A
- Macgillivray Bk
- Machkovska M
- Madjarov S
- Mahadevan Kp
- Mahmood Sm
- Major K
- Makam Sk
- Maloney Mj
- Maltbaek N
- Mandazhieva Pepelanova M
- Mapel D
- Marcipar Am
- Margolis Bd
- Margulies J
- Martin Ee
- Martin Ef
- Martinot Jb
- Martynov A
- Mascolo M
- Maspero Jf
- Mataria H
- Mathur Rn
- Matsuno Fuchigami A
- Mattar Pn
- Maynard Km
- Maynard N
- Mccormick B
- Mcelya M
- Mcevoy Ce
- Mckenzie Wc
- Md Kassim Rm
- Medina Iv
- Medwedeff Le
- Mehta Kd
- Melamed Ir
- Meli Jv
- Merke J
- Merrick Bh
- Meyers Pj
- Mezei M
- Michetti G
- Micke L
- Miller Bt
- Mincewicz G
- Minton Sm
- Miranda Fg
- Mitic Milikic M
- Mitlehner W
- Mizernitski Y
- Mohar De
- Mohd Fadzli Fb
- Monsó Molas E
- Montenegro Ch
- Morris Fa
- Morrison Bs
- Moss Mh
- Mueller H
- Munoz F
- Mészáros I
- Nadaskic R
- Naidenova I
- Naini Gr
- Nakamura Ct
- Naseeruddin S
- Nassim C
- Naudts If
- Naudziunas A
- Naudziunas S
- Navarro Dourdil A
- Navazo Lj
- Nayyar S
- Neamtu Ml
- Nell H
- Nemtsov B
- Nestorovic B
- Neumann G
- Nieto García Aj
- Nieuwoudt G
- Niezgoda K
- Ninane V
- Nissim Je
- Noleva K
- Noor F
- Nordstrom M
- Norman D
- Novozhenov Vg
- O'Connor Tm
- Oberoi Ms
- Offenberger J
- Oldenburg W
- Olszewska-Ziąber A
- Onasz-Manitius M
- Onia Af
- Orr Rr
- Osea Ea
- Overlack A
- Paine Wj
- Palatnik M
- Pandya Hc
- Pangtay D
- Panina Ss
- Panuto Ja
- Panzer F
- Park Cs
- Parker Iw
- Pascoe Sj
- Pasiyeshvili Lm
- Pastorello Ea
- Patel M
- Pavlishchuk S
- Pawlukiewicz M
- Peché R
- Perera Ms
- Perez Chada Rd
- Perez A
- Perpina Tordera M
- Pesci A
- Peters PH Jr
- Petrova I
- Picado Valles C
- Pilette C
- Pimentel SM Jr
- Piotrowicz P
- Piotrowski W
- Pisarczyk-Bogacka E
- Piskorz P
- Pistolesi M
- Plutinsky J
- Pluto Tm
- Poga M
- Pollock Mt
- Popova Vv
- Posner Ls
- Povysilova L
- Pratt Se
- Pravda P
- Prazma Cm
- Pribulova E
- Pritchard Jc
- Prokop-Staszecka A
- Prystupa Ln
- Pudi Kk
- Puig Cm
- Puterman As
- Qaqundah Py
- Quilodran Silva Cn
- Radbill Mk
- Rahman St
- Rai Ib
- Raikhel M
- Raissy Hh
- Rajakulasingam K
- Rakvacs M
- Ramirez-Diaz Sp
- Ramstad Ds
- Ranasinghe Es
- Rangel Os
- Raphiou Ih
- Rapo Se
- Raschal Sp
- Rasmussen Nl
- Reddy Dg
- Rehman Sm
- Reinholz N
- Remppis R
- Reshetko Ov
- Reyes Sr
- Rhodes Rb
- Riegel P
- Riffer E
- Rihal Ps
- Riley ED 4th
- Riva E
- Rizvi Q
- Robinson Pd
- Robinson Pj
- Rodriguez Alvarez Mdel M
- Rodriguez Dh
- Rogers Cm
- Rohlf Jl
- Romaniuk Li
- Romano A
- Romeu H
- Roney Cw
- Ronsick So
- Rosen Jb
- Roslan A
- Rowe Ms
- Rudzeviciene O
- Rueckert P
- Ruoff Ge
- Russo Ma
- Ryan Eh
- S-Naval S
- Saff Rh
- Saini N
- Sajkov D
- Samuels Bs
- Samuelson Rj
- Sandagon Mj
- Saniuk Rj
- Sargeant Wo
- Saunders Mk
- Saura Vinuesa A
- Saway W
- Scarupa Md
- Schaetzl Rj
- Schauer U
- Schear Mj
- Schenkenberger I
- Schlegel V
- Scholz G
- Schroers M
- Schwarz Cm
- Schwittay A
- Scichilone N
- Scott Rb
- Sebert M
- Seddon P
- Segall N
- Seibert Af
- Seidmeyer V
- Seidner Mr
- Seifer Fd
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- Wisman PP Jr
- Wojciechowska I
- Wyszomierski Da
- Yakushin S
- Yamada Hm
- Yarows S
- Yatsyshyn Ri
- Yeakey Am
- Yu Cy
- Yunger TM Jr
- Yunus F
- Zadionchenko V
- Zaitsev I
- Zakova L
- Zeisler Kh
- Zhebel V
- Zhiglinskaya O
- Zibotics H
- Zidel B
- Ziegner A
- Ziering Rw.
- Zimny Hh
- Ziora D
- Zlatos A
- Zubarenko O
- Zykov K
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND:
The safe and appropriate use of long-acting beta-agonists (LABAs) for the treatment of asthma has been widely debated. In two large clinical trials, investigators found a potential risk of serious asthma-related events associated with LABAs. This study was designed to evaluate the risk of administering the LABA salmeterol in combination with an inhaled glucocorticoid, fluticasone propionate.
METHODS:
In this multicenter, randomized, double-blind trial, adolescent and adult patients (age, ≥12 years) with persistent asthma were assigned to receive either fluticasone with salmeterol or fluticasone alone for 26 weeks. All the patients had a history of a severe asthma exacerbation in the year before randomization but not during the previous month. Patients were excluded from the trial if they had a history of life-threatening or unstable asthma. The primary safety end point was the first serious asthma-related event (death, endotracheal intubation, or hospitalization). Noninferiority of fluticasone-salmeterol to fluticasone alone was defined as an upper boundary of the 95% confidence interval for the risk of the primary safety end point of less than 2.0. The efficacy end point was the first severe asthma exacerbation.
RESULTS:
Of 11,679 patients who were enrolled, 67 had 74 serious asthma-related events, with 36 events in 34 patients in the fluticasone-salmeterol group and 38 events in 33 patients in the fluticasone-only group. The hazard ratio for a serious asthma-related event in the fluticasone-salmeterol group was 1.03 (95% confidence interval [CI], 0.64 to 1.66), and noninferiority was achieved (P=0.003). There were no asthma-related deaths; 2 patients in the fluticasone-only group underwent asthma-related intubation. The risk of a severe asthma exacerbation was 21% lower in the fluticasone-salmeterol group than in the fluticasone-only group (hazard ratio, 0.79; 95% CI, 0.70 to 0.89), with at least one severe asthma exacerbation occurring in 480 of 5834 patients (8%) in the fluticasone-salmeterol group, as compared with 597 of 5845 patients (10%) in the fluticasone-only group (P<0.001).
CONCLUSIONS:
Patients who received salmeterol in a fixed-dose combination with fluticasone did not have a significantly higher risk of serious asthma-related events than did those who received fluticasone alone. Patients receiving fluticasone-salmeterol had fewer severe asthma exacerbations than did those in the fluticasone-only group
Enzyme Handbook
- Author
- 339-349
- [10]Siffert O., Emöd, I.
- [11] Fricker L.D., Snyder, S.H.
- [11] Taylor A., Volz, K.W., Lipscomb, W.N., Takemoto, L. J.
- [3] Schmidt U., Weller, D., Holder, A.
- [9]Fujiwara K., Tsuru, D.
- [hie J.N., Dure, L.S.
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- Y Agrawal
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- Y Dasarathy
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- Y Ethoh
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- Y Kido
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- “ (Turk V., Neville, M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1991
- Field of study