6,240 research outputs found

    Place attachment in deprived neighbourhoods: The impacts of population turnover and social mix

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    This paper examines the determinants of individual place attachment, focussing in particular on differences between deprived and others neighbourhoods, and on the impacts of population turnover and social mix. It uses a multi-level modelling approach to take account of both individual- and neighbourhood-level determinants. Data are drawn from a large sample government survey, the Citizenship Survey 2005, to which a variety of neighbourhood-level data have been attached. The paper argues that attachment is significantly lower in more deprived neighbourhoods primarily because these areas have weaker social cohesion but that, in other respects, the drivers of attachment are the same. Turnover has modest direct impacts on attachment through its effect on social cohesion. Social mix has very limited impacts on attachment and the effects vary between social groups. In general, higher status or more dominant groups appear less tolerant of social mix

    Exoplanet science with the LBTI: instrument status and plans

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    The Large Binocular Telescope Interferometer (LBTI) is a strategic instrument of the LBT designed for high-sensitivity, high-contrast, and high-resolution infrared (1.5-13 μ\mum) imaging of nearby planetary systems. To carry out a wide range of high-spatial resolution observations, it can combine the two AO-corrected 8.4-m apertures of the LBT in various ways including direct (non-interferometric) imaging, coronagraphy (APP and AGPM), Fizeau imaging, non-redundant aperture masking, and nulling interferometry. It also has broadband, narrowband, and spectrally dispersed capabilities. In this paper, we review the performance of these modes in terms of exoplanet science capabilities and describe recent instrumental milestones such as first-light Fizeau images (with the angular resolution of an equivalent 22.8-m telescope) and deep interferometric nulling observations.Comment: 12 pages, 6 figures, Proc. SPI

    Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury

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    In response to NIH initiatives to investigate sex as a biological variable in preclinical animal studies, researchers have increased their focus on male and female differences in neurotrauma. Inclusion of both sexes when modeling neurotrauma is leading to the identification of novel areas for therapeutic and scientific exploitation. Here, we review the organizational and activational effects of sex hormones on recovery from injury and how these changes impact the long-term health of spinal cord injury (SCI) patients. When determining how sex affects SCI it remains imperative to expand outcomes beyond locomotor recovery and consider other complications plaguing the quality of life of patients with SCI. Interestingly, the SCI field predominately utilizes female rodents for basic science research which contrasts most other male-biased research fields. We discuss the unique caveats this creates to the translatability of preclinical research in the SCI field. We also review current clinical and preclinical data examining sex as biological variable in SCI. Further, we report how technical considerations such as housing, size, care management, and age, confound the interpretation of sex-specific effects in animal studies of SCI. We have uncovered novel findings regarding how age differentially affects mortality and injury-induced anemia in males and females after SCI, and further identified estrus cycle dysfunction in mice after injury. Emerging concepts underlying sexually dimorphic responses to therapy are also discussed. Through a combination of literature review and primary research observations we present a practical guide for considering and incorporating sex as biological variable in preclinical neurotrauma studies

    The Iowa Homemaker vol.3, no.3-4

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    Table of Contents The Architectural Design of a Home by Allen Holmes Kimball, page 1 “For a Man’s House Is His Castle” by Alda Wilson, page 2 The Economics of Consumption compiled by John E. Brindley, page 3 Sunfast and Tubfast Materials by Pearl Apland, page 5 On Our Street by Juanita J. Beard, page 6 Who Is Responsible for the Child? by Orange H. Cessna, page 7 Summer Suppers by N. Beth Bailey, page 8 Vacation First Aid by Dr. Mary Sheldon, page 9 Episodes Concerning Evolution of Home Economics by Ruth Elaine Wilson, page 10 Extravagant Economics by Blanche Ingersoll, page 11 Breakfast Bridge by Eleanor Murray, page 12 Veishea Celebrates First Birthday by Helen G. Lamb, page 1

    Mechanisms explaining transitions between tonic and phasic firing in neuronal populations as predicted by a low dimensional firing rate model

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    Several firing patterns experimentally observed in neural populations have been successfully correlated to animal behavior. Population bursting, hereby regarded as a period of high firing rate followed by a period of quiescence, is typically observed in groups of neurons during behavior. Biophysical membrane-potential models of single cell bursting involve at least three equations. Extending such models to study the collective behavior of neural populations involves thousands of equations and can be very expensive computationally. For this reason, low dimensional population models that capture biophysical aspects of networks are needed. \noindent The present paper uses a firing-rate model to study mechanisms that trigger and stop transitions between tonic and phasic population firing. These mechanisms are captured through a two-dimensional system, which can potentially be extended to include interactions between different areas of the nervous system with a small number of equations. The typical behavior of midbrain dopaminergic neurons in the rodent is used as an example to illustrate and interpret our results. \noindent The model presented here can be used as a building block to study interactions between networks of neurons. This theoretical approach may help contextualize and understand the factors involved in regulating burst firing in populations and how it may modulate distinct aspects of behavior.Comment: 25 pages (including references and appendices); 12 figures uploaded as separate file

    Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye

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    Retinal vascular diseases are important causes of vision loss. A detailed evaluation of the vascular abnormalities facilitates diagnosis and treatment in these diseases. Optical coherence tomography (OCT) angiography using the highly efficient split-spectrum amplitude decorrelation angiography algorithm offers an alternative to conventional dye-based retinal angiography. OCT angiography has several advantages, including 3D visualization of retinal and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related complications. Results from six illustrative cases are reported. In diabetic retinopathy, OCT angiography can detect neovascularization and quantify ischemia. In age-related macular degeneration, choroidal neovascularization can be observed without the obscuration of details caused by dye leakage in conventional angiography. Choriocapillaris dysfunction can be detected in the nonneovascular form of the disease, furthering our understanding of pathogenesis. In choroideremia, OCT's ability to show choroidal and retinal vascular dysfunction separately may be valuable in predicting progression and assessing treatment response. OCT angiography shows promise as a noninvasive alternative to dye-based angiography for highly detailed, in vivo, 3D, quantitative evaluation of retinal vascular abnormalities.National Institutes of Health (U.S.) (Grant R01-EY023285)National Institutes of Health (U.S.) (Grant R01-EY024544)National Institutes of Health (U.S.) (Grant DP3 DK104397)National Institutes of Health (U.S.) (Grant R01-EY11289)National Institutes of Health (U.S.) (Grant K08-EY021186)National Institutes of Health (U.S.) (Grant T32-EY23211)National Institutes of Health (U.S.) (Grant P30-EY010572)Clinical and Translational Science Award Grant UL1TR000128Research to Prevent Blindness, Inc. (United States) (Grant and Career Development Award CD-NMT-0914-0659-OHSU)United States. Air Force Office of Scientific Research (Foundation Fighting Blindness Career Development Award FA9550-10-1-0551)German Research Foundation (Grant DFG-HO-1791/11-1)German Research Foundation (Grant DFG-GSC80-SAOT

    Inclusive production of charged hadrons in photon–photon collisions

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    The inclusive production of charged hadrons in the collisions of quasi-real photons (e+e−→e+e−+Xe+e−→e+e−+X) has been measured using the OPAL detector at LEP. The data were taken at e+e−e+e− centre-of-mass energies from 183 to 209 GeV209 GeV. The differential cross-sections as a function of the transverse momentum and the pseudorapidity of the hadrons are compared to theoretical calculations of up to next-to-leading order (NLO) in the strong coupling constant αsαs. The data are also compared to a measurement by the L3 Collaboration, in which a large deviation from the NLO predictions is observed

    Hadronic light-by-light corrections to the muon g-2: the pion-pole contribution

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    The correction to the muon anomalous magnetic moment from the pion-pole contribution to the hadronic light-by-light scattering is considered using a description of the pi0 - gamma* - gamma* transition form factor based on the large-Nc and short-distance properties of QCD. The resulting two-loop integrals are treated by first performing the angular integration analytically, using the method of Gegenbauer polynomials, followed by a numerical evaluation of the remaining two-dimensional integration over the moduli of the Euclidean loop momenta. The value obtained, a_{mu}(LbyL;pi0) = +5.8 (1.0) x 10^{-10}, disagrees with other recent calculations. In the case of the vector meson dominance form factor, the result obtained by following the same procedure reads a_{mu}(LbyL;pi0)_{VMD} = +5.6 x 10^{-10}, and differs only by its overall sign from the value obtained by previous authors. Inclusion of the eta and eta-prime poles gives a total value a_{mu}(LbyL;PS) = +8.3 (1.2) x 10^{-10} for the three pseudoscalar states. This result substantially reduces the difference between the experimental value of a_{mu} and its theoretical counterpart in the standard model.Comment: 27 pages, Latex, 3 figures. v2: version to be published in Phys. Rev. D, Note added and references updated (don't worry, sign has not changed
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