225 research outputs found
Uloga moderne anti-androgene terapije u lijeÄenju lokaliziranog raka prostate
Anti-androgen therapy continues to be a basic pilar of treatment for both localized
and metastatic prostate cancer. The advent of new generation of androgen receptor targeted agents
(ARTA) transformed the care of patients with advanced disease. After such a success, the steps were
taken to incorporate a new generation of ARTAs into the treatment landscape of localized prostate
cancer. High-risk prostate cancer represents the most aggressive form of localized disease with
significant metastatic potential and poor outcome. Here, the impact of novel therapies will likely
be profound and transforming. This clinical space has already been a showcase for multidisciplinary
treatment where the combination of local therapies with systemic treatment gradually improved patient
outcomes and the chances of cure. The most recent step in redefining the treatment of localized
disease is the adoption of novel ARTAs moving forward the multidisciplinary platform. In this narrative
review, we discuss current clinical evidence supporting the use of novel ARTAs in patients with
localized high-risk prostate cancer and cover recent developments in biomarker-driven strategies for
treatment individualization in this clinical context.Anti-androgena terapija je temelj lijeÄenja lokaliziranog i uznapredovalog raka prostate. Dolazak nove
generacije lijekova koji inhibiraju androgenu osovinu preobrazila je lijeÄenje bolesnika sa uznapredovalim rakom prostate.
Temeljem uspjeha u uznapredovaloj bolesti, u tijeku su napori da se nova generacija anti-androgenih lijekova inkorporira u
lijeÄenje lokalizirane bolesti. VisokoriziÄan rak prostate predstavlja najagresivniji oblik lokalizirane bolesti sa znaÄajnim metastatskim
potencijalom. Za oÄekivati je da Äe u ovom stadiju utjecaj novih terapija biti preobraĆŸavajuÄi. Lokalizirani visokoriziÄni
rak prostate se lijeÄi multidisciplinarno. Tu su kombinacije lokalnog lijeÄenja i sustavne terapije postepeno popravljale
ishode lijeÄenja i omoguÄavale priliku za izlijeÄenje. Zadnji napor predstavlja usvajanje novih anti-androgenih terapija. U
ovom preglednom Älanku razmatramo kliniÄke dokaze za upotrebu nove generacije anti-adrogene terapije u bolesnika sa
lokaliziranim visokoriziÄnim rakom prostate i dajemo pregled zadnjih strategija za personalizaciju lijeÄenja
HDR Brachytherapy in the Management of High-Risk Prostate Cancer
High-dose-rate (HDR) brachytherapy is used with increasing frequency for the treatment of prostate cancer. It is a technique which allows delivery of large individual fractions to the prostate without exposing adjacent normal tissues to unacceptable toxicity. This approach is particularly favourable in prostate cancer where tumours are highly sensitive to dose escalation and to increases in radiotherapy fraction size, due to the unique radiobiological behaviour of prostate cancers in contrast with other malignancies. In this paper we discuss the rationale and the increasing body of clinical evidence for the use of this technique in patients with high-risk prostate cancer, where it is combined with external beam radiotherapy. We highlight practical aspects of delivering treatment and discuss toxicity and limitations, with particular reference to current practice in the United Kingdom
Body image issues and attitudes towards exercise amongst men undergoing androgen deprivation therapy (ADT) following diagnosis of prostate cancer
© 2019 John Wiley & Sons, Ltd. Background: Androgen deprivation therapy (ADT) is an established treatment for prostate cancer (PCa), but its side-effects can affect body appearance and functioning. However, research into the impact of ADT on body image is limited. Exercise can help patients to counterbalance some side-effects, potentially improving body image too. However, adherence to exercise recommendations is low. Therefore, we explored body image after ADT and attitudes towards exercise. Methods: Twenty two semi-structured interviews were conducted with PCa patients receiving ADT (Mage = 67.9 years old, SD = 9.99). Results: Participants expressed appearance dissatisfaction focusing on body feminization. Participants exercised to counterbalance ADT side-effects and improve mood. Exercise also helped them to re-establish a sense of control over their body and experience a sense of achievement. However, some men described being worried that their appearance and physical performance would be judged by others, so they often exercised alone or gave up exercise. Time management and fatigue were also identified as exercise barriers. Conclusion: These findings highlight the need to further investigate body image concerns and exercise barriers in PCa patients undergoing ADT. These results could also inform support groups and health care professionals on the topic. However, further research should explore the most effective and acceptable ways to provide support to PCa patients on body image issues
Does the cancer drugs fund lead to faster uptake of cost-effective drugs? A time-trend analysis comparing England and Wales
BACKGROUND: The Cancer Drugs Fund (CDF) provides ÂŁ200 million annually in England for âanti-cancer' drugs. METHODS: We used a controlled pre-/post-intervention design to compare IMS Health dispensing data for 15 cancer drugs (2007â2012) in England vs Wales, stratified by pre-CDF NICE drug approval status (rejected, mixed recommendations, recommended, not appraised). RESULTS: The CDF was associated with increased prescribing in England for three of five drugs rejected or with mixed NICE recommendations. The prescribing volume ratios (PVR) ranged from 1.29 (95% CI 1.00, 1.67) for sorafenib to 3.28 (2.59, 4.14) for bevacizumab (NICE rejected) and 0.93 (0.81, 1.06) and 1.35 (1.21, 1.49) for sunitinib and imatinib respectively (mixed recommendations). Post CDF prescribing in England increased for both drugs awaiting NICE appraisal pre-CDF (lapatinib PVR=7.44 (5.81, 9.54), panitumumab PVR=5.40 (1.20, 24.42)) and subsequently rejected. The CDF was not associated with increased prescribing in England of NICE-recommended drugs. The three most recently launched, subsequently recommended drugs were adopted faster in Wales (from pazopanib PVR=0.51 (0.28, 0.96) to abiraterone PVR=0.78 (0.61â0.99)). INTERPRETATION: These data indicate that the CDF is used to access drugs deemed not cost-effective by NICE. The CDF did not expedite access to new cost-effective cancer agents prior to NICE approval
Exploring the role of âGlycerine plus Honeyâ in delaying chemoradiation induced oral mucositis in head and neck cancers
Purpose: The purpose of this study was to assess the efficacy of adding âGlycerine plus Honeyâ to standard management protocol, in terms of time to delay in oral mucositis â„ grade 2.Methods: Hundred patients of oral cavity and oropharangeal cancers, planned for concurrent chemoradiation (Dose: 60â66 Gy/30-33 fractions) were randomized 1:1 to receive either home-made remedy made of âGlycerine plus Honeyâ added to the standard management protocol to prevent mucositis versus standard treatment alone. CTCAE v 4 (Common toxicity criteria for adverse events) was used for assessing oral mucositis scores weekly. Chi square test was used to compare mucositis scores, weight loss, opioid use, ryles tube feeding, and unplanned treatment breaks in each cohort. Independent T-test was used to compare means to assess the effect of treatment in delaying mucositis â„ grade 2.Results: Significantly higher number of patients developed grade â„ 2 mucositis in control arm [n = 43 (86%)] compared to study arm [n = 30 (60%)] (p = 0.003). CTCAE scores favored Glycerine plus honey at week 4, and on last day of radiotherapy. Whereas, time to first occurrence of oral mucositis grade â„ 2 was 23.17 (± 1.01) days for study arm [radiation dose 31.67 Gy (± 1.44)], it was 20.65 (± 0.8) days for control arm [radiation dose 28.14 Gy (± 1.16)] (p = 0.05). Study patients had lesser weight loss (2.76 kg) than control subjects (3.9 kg) with p = 0.008. There were significantly higher number of patients in control arm who required opioid analgesia, ryles tube insertion and had unplanned treatment breaks, compared to study arm.Conclusion: Glycerine plus honey demonstrated superiority in delaying oral mucositis, and the combination is safe and well tolerable.
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