Ozone therapy: Myth and fact [Ozon Terapi: Mit Ve Gerçek]

Ozone is the one of the most potent oxidant in the nature. It is found in tricyclic molecular form. Ozone therapy is a kind of oxidative stress, which is achieved by either direct ozone injection into the tissues or reinfusion of ozonated blood of the patient. Ozone shows its effect via secondary messengers, which are hidrogen peroxide and lipid oxidation products from oxidation of the polyunsaturated fatty acids in the cell membrane. As a result of this controlled stress, the anti oxidant mechanisms, immunity system and other neurohumoral mechanisms are activated. It is more likely a " physiological vaccine." Currently,ozon therapy was indicated in the case of circulatory disturbances, degenerative disesases, musculo-skeletal pathologies, some infectional diseases, chronic wounds. Ozone should not be used in patients with respiratory system pathologies, in pregnants, in glucose 6 phosphate dehydrogenase deficiency, favism, and uncontralable hyperthyroidisim. Ozone therapy is not approved by the FDA, contrary it is classified as a toxic material. In Turkey, there is no any legal regulation yet. As a conclusion, the ozone therapy cannot be accepted neither primary nor secondary treatment modalitiy, on the other hand, we cannot ignore succesful results in the literature

Polypoid formation of cysts in scrotal calcinosis: An uncommon case [15]

[No abstract available

Dual preconditioning: Effects of pharmacological plus ischemic preconditioning on skin flap survival

To enhance skin flap viability, pharmacological and ischemic preconditioning methods were investigated intensively. This study was designed to determine whether combined local dexamethasone administration and pedicle clamping would result in an additive enhancement of skin flap survival in the rat model. Twenty-eight male Sprague-Dawley rats were included in dexamethasone injection, clamping, clamping plus dexamethasone injection, and control groups. A rectangular random skin flap (3 x 11 cm) was outlined as bipedicled on the back of the animals. The dexamethasone or saline injection points in the flap were standardized. In the dexamethasone injection group, after raising the flaps, a total of 2.5 mg/kg dexamethasone was injected into the flaps. In the ischemic preconditioning group, 1 hour after saline injection, the cranial pedicle was clamped for 20 minutes and then 40 minutes reperfusion was performed. The clamping-plus-dexamethasone injection group was the same as the clamping group except dexamethasone was injected instead of the saline. In the control group, saline was injected instead of dexamethasone. Regardless of the group, all flaps were cut at the cranial side at the end of the 2 hours and were sutured back. On day 7, the surviving area was significantly greater in all experimental groups compared with the control group (p < 0.05). Furthermore, the clamping-plus-dexamethasone group demonstrated the highest flap viability

A case of lipoma of the deep lobe of the parotid gland.

Lipoma of the deep lobe of the parotid gland is extremely rare. A forty-two-year-old man presented with a painless, soft, and slow-growing mass in the left preauricular area. Ultrasonography and computed tomography findings were consistent with lipoma. The patient was treated with superficial parotidectomy and total excision of the mass with preservation of the facial nerve. Histologic findings confirmed the diagnosis. No recurrences were detected during 1.5 years in the postoperative period

Effect of Steroids on Edema, Ecchymosis, and Intraoperative Bleeding in Rhinoplasty

A double-blind, randomized study was designed to determine the efficacy of dexamethasone in decreasing periorbital edema and ecchymosis after rhinoplasty. Sixty rhinoplasty patients undergoing hump resection and lateral osteotomy were included in the study and were divided into 6 groups: group 1 (n = 10), single dose of 8 mg intravenous (IV) dexamethasone 1 hour before the operation; group 2 (n = 10), single dose of 8 mg IV dexamethasone at the beginning of the operation; group 3 (n = 10), 3 doses of 8 mg IV dexamethasone 1 hour before the operation, and 24 and 48 hours after the operation; group 4 (n = 10), 3 doses of 8 mg IV dexamethasone at the beginning of the operation, and 24 and 48 hour after the operation; group 5 (n = 10), 3 doses of 8 mg IV dexamethasone immediately after the operation, and 24 and 48 hours after the operation; group 6 (n = 10), control, no dexamethasone administration before or after the operation. Intraoperative blood loss was recorded for each patient. Patients were evaluated at 24 hours and days 2, 5, 7, and 10. For the postoperative evaluation of periorbital ecchymosis and edema, a scale of 0 to 4 points was used. There was no significant difference between groups in terms of bleeding (P > 0.05). In the groups using steroid before osteotomy, edema and ecchymosis were significantly lower during the first 2 days compared with the control group (P 0.05). There was no significant difference between groups on day 10. In conclusion, if the first dose is given before osteotomy, triple-dose steroid application is the best bet for decreasing postoperative edema and ecchymosis. None of the patients had any complications related to the use of dexamethasone

A Training Model for Cutaneous Surgery

BACKGROUND. Training models are necessary for development of many skills in medical education. OBJECTIVE. To develop a training model for improvement of simple surgical procedure skills. METHODS. A convex, rectangular, smooth-surfaced wooden plate covered by first cotton material and then polyethylene stretch film was used. Skins of rats that had been used previously for experimental studies were attached on the wooden plate. In order to see efficacy of our model, we decided to use it in a cutaneous surgery workshop. Theoretical and practical information about surgical sutures, punch biopsy, excisional biopsy, rotational flap, and Z-plasty procedures was given to the participant physicians. Surgical skills of participants were scored before and after the practical part of workshop. RESULTS. Thirty-three physicians were enrolled voluntarily to the workshop. All participants showed statistically significant increase in scores (P < 0.05). CONCLUSION. The similarity to human skin and the easy setup make this training model an ideal teaching tool to improve the skills of physicians for simple cutaneous surgery

Multiple eccrine spiradenoma in zosteriform distribution [14]

[No abstract available

Fascia lata grafts for closure of secondary urethral fistulas

Objectives. To evaluate the efficacy of fascia lata graft in the repair of secondary urethral fistulas. Urethral fistulas may result from a complication of hypospadias repair. The treatment of urethral fistulas is quite challenging. Methods. This technique was used in 8 patients between 2000 and 2002. All patients had undergone hypospadias repair and had recurrent fistula formation. A 2 × 2-cm fascia lata graft was harvested from the lateral aspect of the thigh. After repair of the fistula, the fascia lata graft was placed between the urethra and skin. The mean age of the patients was 8 years (range 5 to 13). Results. During 8 to 22 months (average 11) of follow-up, no recurrence of urethral fistula was observed. No complications occurred, and patients were completely satisfied with the results. Conclusions. The results of this study show that the fascia lata graft can be used for the closure of urethral fistula secondary to hypospadias repair. Additional studies are warranted. © 2003 Elsevier Inc

Fascia lata graft for urethral fistula repair [5] (multiple letters)

[No abstract available