Identification and nitric oxide production inhibitory activity of phenolic derivatives from the trunks of <i>Gnetum latifolium</i>

Phytochemical investigation of the trunks from Gnetum latifolium led to the isolation of a novel phenolic glucoside, 2E-2,4-di-(3,4-dihydroxyphenyl)but-2-en-1-yl-O-β-D-glucopyranoside (1), along with five known stilbene derivatives (2–6). Their structures were determined mainly using high-resolution electrospray ionisation mass spectrometry and nuclear magnetic resonance spectroscopic analyses, followed by comparisons of observed spectral data with reported values. The novel compound 1 in G. latifolium was found to be useful as a chemotaxonomic marker. Biological evaluation revealed that compound 6 had remarkable inhibitory effects on nitric oxide production, with a half-maximal inhibitory concentration (IC50) value of 4.85 ± 0.20 µM, which was much higher than that of the positive control dexamethasone (IC50 = 14.20 ± 0.54 µM).</p

sj-doc-1-npx-10.1177_1934578X231201037 - Supplemental material for Synthesis and Evaluation of Acetylcholinesterase Inhibitory and Cytotoxic Activities of Pyrano[2,3-<i>d</i>]pyrimidines

Supplemental material, sj-doc-1-npx-10.1177_1934578X231201037 for Synthesis and Evaluation of Acetylcholinesterase Inhibitory and Cytotoxic Activities of Pyrano[2,3-d]pyrimidines by Nguyen Ha Thanh, Nguyen Thi Quynh Giang, Nguyen Van Ha, Hoang Thi Phuong, Le Nhat Thuy Giang, Nguyen Tuan Anh, Ba Thi Cham, Le Duc Huy, Dang Thi Tuyet Anh, Phan Van Kiem and Nguyen Van Tuyen in Natural Product Communications</p