24 research outputs found
Relaxation of arterial smooth muscle by water-soluble derivatives of coenzyme Q (ubiquinone)
Treatment of coenzyme Q with ozone, permanganate, and ferrous sulfate in presence of ascorbate or hydrogen peroxide yielded water-soluble degradation products, possibly having truncated side-chain and modified ring.These derivatives, but not the intact lipid-quinone, showed relaxation of phenylephrine-contracted rat arterial rings. Representative samples of these also decreased blood pressure when injected into the femoral vein in the rat.These effects offer an explanation for the hypotensive action of exogenous coenzyme Q regardless of its side-chain length
Analgesic activity of new synthetic thiazolidine-4-ones derivatives
812-815Ten new synthetic thiazolidine-4-ones derivatives
(5 chlorothiazolidine-4-ones, 3 methoxythiazolidine-4-ones and 2 hydoxythiazolidine-4-ones)
having different substituents at R1, R2 and R3 were evaluated for their analgesic
activity using different animal models and their structure activity relationship
was also elucidated. Chlorothiazolidine-4-ones and
methoxythiazolidine-4-ones exhibited analgesic
activity in tail flick test, tail immersion test and acetic acid writhing test.
C-III (chloride substituents at R1 and R2) produced higher latencies than any other
compounds in tail flick test and C-I (no substituents at R1 and R2) was not effective
in acetic acid writhing test. Hydroxythiazolidine-4-ones did not show analgesic
activity in any of the animal models used. In conclusion, the character of substituents
at R3 of thiazolidine moiety position may have an effect on the analgesic activity
of thiazolidine-4-ones and either chloride or methoxy substitution may be necessary
to produce analgesic activity. Two chloride substituents in a compound may increase
the central analgesic activity of the compound
Relaxation of arterial smooth muscle: A new function of a water-soluble degradation product of coenzyme Q (ubiquinone)
Treatment of coenzyme Q with ozone yielded a degradation product having unmodified ring that retained its spectral characteristics and a truncated side-chain that made it water-soluble. This derivative, but not the intact lipid-quinone, showed relaxation of phenylephrine-contracted rat arterial rings. This effect offers an explanation for the known hypotensive action of exogenous coenzyme Q regardless of its side-chain length