EFFECT OF COMPOSITION ON THE RELEASE FROM MELT EXTRUDED LAMINAR SYSTEMS BY APPLICATION OF MIXTURE EXPERIMENTAL DESIGN

EFFECT OF COMPOSITION ON THE RELEASE FROM MELT EXTRUDED LAMINAR SYSTEMS BY APPLICATION OF MIXTURE EXPERIMENTAL DESIG

Solid state mechanochemical activation of Sylibum marianum dry extract with betacyclodextrins: characterization and bioavailability of the coground systems

Silybum marianum dry extract, whose therapeutic use is partially restricted by the insolubility in water of its main flavonolignans, was subjected to a mechanochemical activation process in planetary mill using betacyclodextrins as carriers. After optimization of the operating conditions according to an established theoretical model, the best active-to-carrier proportion was selected from the preliminary trials. When using the optimized conditions, the mechanochemical process permits an improvement of the physico-chemical properties of the active, which reaches an \u2018\u2018activated\u2019\u2019 solid state, that is stable for at least 1 year. The activated solid state of the coground systems remarkably enhanced the in vitro drug dissolution kinetics with consequent improved oral bioavailability. Furthermore, the in vivo studies on rats revealed a 6.6-fold bioavailability increase respect to the S. marianum Italian commercial product used as reference

Development of Cyclosporine-A in nanoemulsified composites (NECTM)

Formulation and characterization approach of cyclospirin-A in nanoemulsified composites