Luminosity levelling techniques for the LHC

We present the possibilities for doing luminosity levelling at the LHC. We explore the merits and drawbacks of each option and briefly discuss the operational implications. The simplest option is levelling with an offset between the two beams. Crab cavities may also be used for levelling, as may a squeezing of the beam. There is also the possibility of using the crossing angle in order to do luminosity levelling. All of these options are explored, for the LHC and other possible new projects, together with their benefits and drawbacks.Comment: 5 pages, contribution to the ICFA Mini-Workshop on Beam-Beam Effects in Hadron Colliders, CERN, Geneva, Switzerland, 18-22 Mar 201

Hopf instantons and the Liouville equation in target space

We generalise recent results on Hopf instantons in a Chern--Simons and Fermion theory in a fixed background magnetic field. We find that these instanton solutions have to obey the Liouville equation in target space. As a consequence, these solutions are given by a class of Hopf maps that consist of the composition of the standard Hopf map with an arbitrary rational map.Comment: Latex file, 11 pages, no figure

Bad housekeeping: why do aphids leave their exuviae inside the colony?

<p>Abstract</p> <p>Background</p> <p>Animals can gain protection against predators and parasites by living in groups. The encounter-dilution effect provides protection when the probability of detection of a group does not increase in proportion to group size (i.e. encounter effect), so that predators do not offset the encounter effect by attacking more members of the group (i.e. dilution effect). In this paper, we propose a novel mechanism by which prey insects could gain by producing decoys that act as multiple targets for predators or parasitoids if these decoys are recognised as preys or hosts and negatively affect the patch foraging strategy of these predators and parasitoids. Such a decoy mechanism could be present in aphid colonies in which aphid exuviae are recognised and attacked by Aphidiine wasps.</p> <p>Results</p> <p>We conducted a behavioural study to evaluate the effect of exuviae on parasitoid patch residence time and egg allocation in experimental aphid patches with or without exuviae. We showed that exuviae are recognised and attacked at the same level as aphids when both are present in the patch. While parasitism rate was not significantly lower in patches with exuviae when the parasitoid left the patch, the time wasted by parasitoids to handle exuviae did influence the patch residence time. As a consequence, the attack rate on the live aphids was lower in patches that contain exuviae.</p> <p>Conclusion</p> <p>Aphids had more time available to flee and thus each individual might gain protection against parasitoids by leaving their exuviae near and within the colony. These results demonstrate that the encounter-dilution effect provided by living in a group can be enhanced by extra-materials that act as decoy for natural enemies.</p

Growth in a Biofilm Sensitizes \u3ci\u3eCutibacterium acnes\u3c/i\u3e to Nanosecond Pulsed Electric Fields

The Gram-positive anaerobic bacterium Cutibacterium acnes (C. acnes) is a commensal of the human skin, but also an opportunistic pathogen that contributes to the pathophysiology of the skin disease acne vulgaris. C. acnes can form biofilms; cells in biofilms are more resilient to antimicrobial stresses. Acne therapeutic options such as topical or systemic antimicrobial treatments often show incomplete responses. In this study we measured the efficacy of nanosecond pulsed electric fields (nsPEF), a new promising cell and tissue ablation technology, to inactivate C. acnes. Our results show that all tested nsPEF doses (250 to 2000 pulses, 280 ns pulses, 28 kV/cm, 5 Hz; 0.5 to 4 kJ/ml) failed to inactivate planktonic C. acnes and that pretreatment with lysozyme, a naturally occurring cell-wall-weakening enzyme, increased C. acnes vulnerability to nsPEF. Surprisingly, growth in a biofilm appears to sensitize C. acnes to nsPEF-induced stress, as C. acnes biofilm-derived cells showed increased cell death after nsPEF treatments that did not affect planktonic cells. Biofilm inactivation by nsPEF was confirmed by treating intact biofilms grown on glass coverslips with an indium oxide conductive layer. Altogether our results show that, contrary to other antimicrobial agents, nsPEF kill more efficiently bacteria in biofilms than planktonic cells