161 research outputs found
A Meinardus theorem with multiple singularities
Meinardus proved a general theorem about the asymptotics of the number of
weighted partitions, when the Dirichlet generating function for weights has a
single pole on the positive real axis. Continuing \cite{GSE}, we derive
asymptotics for the numbers of three basic types of decomposable combinatorial
structures (or, equivalently, ideal gas models in statistical mechanics) of
size , when their Dirichlet generating functions have multiple simple poles
on the positive real axis. Examples to which our theorem applies include ones
related to vector partitions and quantum field theory. Our asymptotic formula
for the number of weighted partitions disproves the belief accepted in the
physics literature that the main term in the asymptotics is determined by the
rightmost pole.Comment: 26 pages. This version incorporates the following two changes implied
by referee's remarks: (i) We made changes in the proof of Proposition 1; (ii)
We provided an explanation to the argument for the local limit theorem. The
paper is tentatively accepted by "Communications in Mathematical Physics"
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Cosmochemical Derivation of the Composition of Chondrite Material.
第2回極域科学シンポジウム/第34回南極隕石シンポジウム 11月17日(木) 国立国語研究所 2階講
Ordinary Chondrites and the Origin of the Earth
第3回極域科学シンポジウム/第35回南極隕石シンポジウム 11月29日(木)、30日(金) 国立国語研究所 2階講
Localization corrections to the anomalous Hall effect in a ferromagnet
We calculate the localization corrections to the anomalous Hall conductivity
related to the contribution of spin-orbit scattering into the current vertex
(side-jump mechanism). We show that in contrast to the ordinary Hall effect,
there exists a nonvanishing localization correction to the anomalous Hall
resistivity. The correction to the anomalous Hall conductivity vanishes in the
case of side-jump mechanism, but is nonzero for the skew scattering. The total
correction to the nondiagonal conductivity related to both mechanisms, does not
compensate the correction to the diagonal conductivity.Comment: 7 pages with 7 figure
Optical Tamm states in one-dimensional magnetophotonic structures
We demonstrate the existence of a spectrally narrow localized surface state,
the so-called optical Tamm state, at the interface between a 1D magnetophotonic
and non-magnetic photonic crystals. The state is spectrally located inside the
photonic band gaps of each of the photonic crystals comprising this
magnetophotonic structure. This state is associated with a sharp transmission
peak through the sample and is responsible for the substantial enhancement of
the Faraday rotation for the corresponding wavelength. The experimental results
are in excellent agreement with the theoretical predictions
Inverse Borrmann effect in photonic crystals
The Borrmann effect, which is related to the microscopic distribution of the
electromagnetic field inside the primitive cell, is studied in photonic and
magnetophotonic crystals. This effect, well-known in x-ray spectroscopy, is
responsible for the enhancement or suppression of various linear and nonlinear
optical effects when the incidence angle and/or the frequency change. It is
shown that by design of the primitive cell this effect can be suppressed and
even inverted
Metastases: the glycan connection
An association between protein glycosylation and tumorigenesis has been recognized for over 10 years. Associations linking the importance of glycosylation events to tumor biology, especially the progression to metastatic disease, have been noted over many years, Recently, a mouse model in which β1,6-N-acetylglucosaminyltransferase V (a rate-limiting enzyme in the N-glycan pathway) has been knocked out, was used to demonstrate the importance of glycosylation in tumor progression. By crossing mice lacking this enzyme with a transgenic mouse model of metastatic breast cancer, metastatic progression of the disease was dramatically reduced. These experiments provide in vivo evidence for the role of N-linked glycosylation in metastatic breast cancer and have significant implications for the development of new treatment strategies
Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children
Mild gestational diabetes in pregnancy and the adipoinsular axis in babies born to mothers in the ACHOIS randomised controlled trial
BACKGROUND: Mild gestational diabetes is a common complication of pregnancy, affecting up to 9% of pregnant women. Treatment of mild GDM is known to reduce adverse perinatal outcomes such as macrosomia and associated birth injuries, such as shoulder dystocia, bone fractures and nerve palsies. This study aimed to compare the plasma glucose concentrations and serum insulin, leptin and adiponectin in cord blood of babies of women (a) without gestational diabetes mellitus (GDM), (b) with mild GDM under routine care, or (c) mild GDM with treatment. METHODS: 95 women with mild GDM on oral glucose tolerance testing (OGTT) at one tertiary level maternity hospital who had been recruited to the ACHOIS trial at one of the collaborating hospitals and randomised to either Treatment (n = 46) or Routine Care (n = 49) and Control women with a normal OGTT (n = 133) were included in the study. Women with mild GDM (treatment or routine care group) and OGTT normal women received routine pregnancy care. In addition, women with treated mild GDM received dietary advice, blood glucose monitoring and insulin if necessary. The primary outcome measures were cord blood concentrations of glucose, insulin, adiponectin and leptin. RESULTS: Cord plasma glucose was higher in women receiving routine care compared with control, but was normalized by treatment for mild GDM (p = 0.01). Cord serum insulin and insulin to glucose ratio were similar between the three groups. Leptin concentration in cord serum was lower in GDM treated women compared with routine care (p = 0.02) and not different to control (p = 0.11). Adiponectin was lower in both mild GDM groups compared with control (Treatment p = 0.02 and Routine Care p = 0.07), while the adiponectin to leptin ratio was lower for women receiving routine care compared with treatment (p = 0.08) and control (p = 0.05). CONCLUSION: Treatment of women with mild GDM using diet, blood glucose monitoring and insulin if necessary, influences the altered fetal adipoinsular axis characteristic of mild GDM in pregnancy
Identification of Protein Targets of Reactive Metabolites of Tienilic Acid in Human Hepatocytes
This document is the Accepted Manuscript version of a Published Work that appeared in final form in
Chemical Research in Toxicology, copyright © American Chemical Society after peer review and technical editing by the publisher.
To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/tx300103jTienilic acid (TA) is a uricosuric diuretic that was withdrawn from the market only months after its introduction because of reports of serious incidents of drug-induced liver injury including some fatalities. Its hepatotoxicity is considered to be primarily immunoallergic in nature. Like other thiophene compounds, TA undergoes biotransformation to a S-oxide metabolite which then reacts covalently with cellular proteins. To identify protein targets of TA metabolites, we incubated [14C]-TA with human hepatocytes, separated cellular proteins by 2D gel electrophoresis, and analyzed proteins in 36 radioactive spots by tryptic digestion followed by LC-MS/MS. Thirty one spots contained at least one identifiable protein. Sixteen spots contained only one of 14 non-redundant proteins which were thus considered to be targets of TA metabolites. Six of the 14 were also found in other radioactive spots that contained from 1 to 3 additional proteins. Eight of the 14 had not been reported to be targets for any reactive metabolite other than TA. The other 15 spots each contained from 2–4 identifiable proteins, many of which are known targets of other chemically reactive metabolites, but since adducted peptides were not observed, the identity of the adducted protein(s) in these spots is ambiguous. Interestingly, all the radioactive spots corresponded to proteins of low abundance, while many highly abundant proteins in the mixture showed no radioactivity. Furthermore, of approximately 16 previously reported protein targets of TA in rat liver (Methogo, R., Dansette, P. and Klarskov, K. (2007) Int. J. Mass Spectrom., 268, 284–295), only one (fumarylacetoacetase) is among the 14 targets identified in this work. One reason for this difference may be statistical, given that each study identified a small number of targets from among thousands present in hepatocytes. Another may be the species difference (i.e. rat vs. human), and still another may be the method of detection of adducted proteins (i.e. Western blot vs. C-14). Knowledge of human target proteins is very limited. Of more than 350 known protein targets of reactive metabolites, only 42 are known from human and only 21 of these are known to be targets for more than one chemical. Nevertheless, the demonstration that human target proteins can be identified using isolated hepatocytes in vitro should enable the question of species differences to be addressed more fully in the future
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