Investigation of the Mechanical Properties of Flexible Polyether Foam Filled with Eggshell and Groundnut Husk Powder

The study investigated the effect of eggshell and groundnut husk as fillers on flexible polyether foam. The fillers with the mesh sizes of 50µm respectively were mixed in the ratio of 50-50. Varying percentages of the mixed fillers ranging from 10%, 20%, 30%, 40% and 50% were incorporated into the polyether recipes in the appropriate foam formulations and foam samples were produced. The unfilled foam (0%filler) served as the standard control sample. The physico-mechanical test carried out on the foam showed increase in the properties such as density, compression set test, indentation hardness test, tensile strength test and decrease for elongation at break test as compared to the unfilled foam. The scanning electron microscopy result showed the cell sizes became smaller and concentrated with an irregular shape as the filler load increased, thereby making it denser and thicker. Eggshell and groundnut husk can be used in the production of flexible polyether foam since they are organic materials. They can enhance the mechanical properties and biodegradability of polyurethane product. The use of fillers in polymer composite will help in sanitizing the environment by reducing landfills and producing eco-friendly waste and also it influences cost positively.

Assessment of knowledge, attitude and practice of COVID-19 guidelines among health care workers in Alex Ekwueme Federal University teaching hospital, Abakaliki, Ebonyi State, Nigeria

Background: COVID-19 is a major Public Health challenge that has affected the world’s economy. Assessment of the knowledge, attitude and practices of Healthcare workers (HCWs) towards COVID-19 can improve or sustain the successes recorded by relevant agencies in the fight against COVID-19.Methods: a cross-sectional survey was done using semi-structured questionnaires and simple sampling technique. Data collected were analyzed using SPSS version 22.Results: Out of the 368 respondents, 205 were doctors while 150 were nurses. Others were clerical workers, administrative officers and maintenance workers. Knowledge of COVID-19 was generally high amongst respondents recording a correct response to questions about knowledge of COVID-19 in more than 90% of the case. However, the attitude and practice of COVID-19 infection, prevention and control protocols were poor. Out of the respondents, 41.8% would not stay at home if they had minor COVID-19 like symptoms; only 39.4% would take responsibility to ensure people around them follow good respiratory hygiene. Respondents who would keep social distancing while talking with co-workers, ensure safe disposal of personal protective equipment (PPEs) and safe waste management of PPEs were 56%, 39.9% and 53.8% respectively.Conclusions: Knowledge of COVID-19 prevention protocols is high but attitude/practice of these laid out protocols still desires a lot of effort from HCWs. There is need for training/retraining of HCWs on COVID-19 infection, prevention and control strategies to ensure the success being recorded against the disease is sustained while preventing the possibility of a second wave of infection

Correlation between serum uric acid levels and outcomes of pre-eclampsia in Abakaliki, South-east, Nigeria

Background: Pre-eclampsia is a leading cause of fetomaternal and perinatal morbidity and mortality. The role of serum uric acid (SUA) in determining the complications of preeclampsia has been controversial. This study compared mean SUA levels between severe pre-eclamptics and normotensive women at term and ascertained its correlation with outcomes of preeclampsia; as well as determined if there is a threshold value of SUA level beyond which fetomaternal complications occur.Methods: A case-controlled study where 80 severe pre-eclamptics at term and 80 normotensive women matched for gestational age were recruited. Blood samples were collected from them for assay of SUA levels and they were followed till delivery. The fetomaternal outcomes and the corresponding SUA levels at diagnosis were documented and variables statistically analyzed. A receiver operating characteristic curve was used to determine the cut-off value of SUA beyond which adverse fetomateral complications are likely to occur in pre-eclampsia.Results: The mean SUA level in severe pre-eclamptics (0.283±0.09 mmol/l) was not significantly higher than that of normotensive women (0.263±0.09 mmol/l, p=0.13). There was a weak positive correlation between the SUA levels and fetomaternal outcomes [maternal (r=0.102, p=0.236) and fetal (r=0.096, p=0.226)]. The study was unable to identify the threshold SUA level at which adverse fetomaternal outcomes occur as the values of SUA were closely related.Conclusions: SUA levels of pre-eclamptics and normotensive women did not show significant difference and correlated weakly with fetomaternal outcomes and are therefore poor predictor of fetomaternal outcomes in pre-eclampsia

Contextual factors predicting compliance behavior during the COVID-19 pandemic: A machine learning analysis on survey data from 16 countries

Voluntary isolation is one of the most effective methods for individuals to help prevent the transmission of diseases such as COVID-19. Understanding why people leave their homes when advised not to do so and identifying what contextual factors predict this non-compliant behavior is essential for policymakers and public health officials. To provide insight on these factors, we collected data from 42,169 individuals across 16 countries. Participants responded to items inquiring about their socio-cultural environment, such as the adherence of fellow citizens, as well as their mental states, such as their level of loneliness and boredom. We trained random forest models to predict whether someone had left their home during a one-week period during which they were asked to voluntarily isolate themselves. The analyses indicated that overall, an increase in the feeling of being caged leads to an increased probability of leaving home. In addition, an increased feeling of responsibility and an increased fear of getting infected decreased the probability of leaving home. The models predicted compliance behavior with between 54% and 91% accuracy within each country’s sample. In addition, we modeled factors leading to risky behavior in the pandemic context. We observed an increased probability of visiting risky places as both the anticipated number of people and the importance of the activity increased. Conversely, the probability of visiting risky places increased as the perceived putative effectiveness of social distancing decreased. The variance explained in our models predicting risk ranged from < .01 to .54 by country. Together, our findings can inform behavioral interventions to increase adherence to lockdown recommendations in pandemic conditions.info:eu-repo/semantics/publishedVersio

Quality of work life and job satisfaction among early-career pharmacists in Africa’s most populous country: A nationwide survey in Nigeria

This study examined the factors affecting the quality of work life and job satisfaction among early-career pharmacists in Nigeria. This was a cross-sectional survey conducted across the six geopolitical zones in Nigeria. We used the database of licensed pharmacists in each selected state to identify eligible participants. Information sheets were sent to all potential participants through email. If interested, they signed the consent form and were sent the survey online to be completed and returned within 24 h. Validated questionnaires were used to evaluate their quality of work life and job satisfaction. Descriptive statistics (frequency, mean, and standard deviation) were used to summarize the data. Of a total of 373 participants; 323 (86.6%) were single, and 245 (65.7%) were working in government-owned hospitals. The findings showed that the quality of work life information affects the job satisfaction of early-career pharmacists. Reasons reported for poor job satisfaction were poor remuneration, increased workload, a lack of employer support, and an unconducive work environment. Suggestions for possible interventions included an increase in remuneration, an accommodating work atmosphere, and flexible working hours. Our findings show a direct relationship between quality of work life and job satisfaction; predictors of job satisfaction were salary, employer assistance, health insurance, and length of leave

A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma

<p>Abstract</p> <p>Background</p> <p>Osteosarcoma (OS) is a bone malignancy which occurs primarily in adolescents. Since it occurs during a period of rapid growth, genes important in bone formation and growth are plausible modifiers of risk. Genes involved in DNA repair and ribosomal function may contribute to OS pathogenesis, because they maintain the integrity of critical cellular processes. We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ribosomal pathways.</p> <p>Methods</p> <p>We evaluated 4836 tag-SNPs across 255 candidate genes in 96 OS cases and 1426 controls. Logistic regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (CI).</p> <p>Results</p> <p>Twelve SNPs in growth or DNA repair genes were significantly associated with OS after Bonferroni correction. Four SNPs in the DNA repair gene <it>FANCM </it>(ORs 1.9-2.0, <it>P </it>= 0.003-0.004) and 2 SNPs downstream of the growth hormone gene <it>GH1 </it>(OR 1.6, <it>P </it>= 0.002; OR 0.5, <it>P </it>= 0.0009) were significantly associated with OS. One SNP in the region of each of the following genes was significant: <it>MDM2</it>, <it>MPG</it>, <it>FGF2</it>, <it>FGFR3</it>, <it>GNRH2</it>, and <it>IGF1</it>.</p> <p>Conclusions</p> <p>Our results suggest that several SNPs in biologically plausible pathways are associated with OS. Larger studies are required to confirm our findings.</p