Gaining insight into exclusive and common transcriptomic features linked with biotic stress responses in Malus

Identifying key information in transcriptomic data is very important, especially when the “omic” study deals with plant responses to stresses in field conditions where a high number of variables and disturbing factors may affect the analysis. In this meta-analysis we collected 12 transcriptomic works in Malus in order to identify which key genes, proteins, gene categories are involved in general plant pathological conditions and those features linked with exclusive biotic stress responses. Those genes that are only related with molecular responses to pathogen attacks and those linked with other plant physiological processes were identified. A pipeline composed by pathway and gene set enrichment analysis, protein-protein interaction networks and gene visualization tools was employed. A total of 13,230 genes of the 12 studies were analyzed with functional data mining tools: 5,215 were upregulated, 8,015 were downregulated. Gene set enrichment analysis pointed out that photosynthesis was inhibited by Erwinia amylovora and fungal pathogens. Different hormonal crosstalk was linked with responses to different pathogens. Gibberellin-related pathways, ABA-related were mostly repressed by fungal pathogens. Relating to transcription factors, genes encoding MYBs and WRKY2 were downregulated by fungal pathogens and 12 WRKYs were commonly regulated by different biotic stresses The protein-protein interaction analysis discovered the presence of several proteins affected by more than one biotic stress including a WRKY40 and some highly interactive proteins such as heat shock proteins. This study represents a first preliminary curated meta-analysis of apple transcriptomic responses to biotic stresses

Sumber stres, strategi daya tindak dan stres yang dialami pelajar universiti

Kajian ini bertujuan mengkaji sumber stres, strategi daya tindak dan stres yang dialami pelajar sebuah universiti di Kota Kinabalu, Sabah. Secara khususnya, kajian ini dilaksanakan bagi mengenal pasti hubungan antara sumber stres dan stres yang dialami pelajar universiti. Di samping itu, kajian ini cuba meneliti bentuk strategi daya tindak yang digunakan oleh pelajar universiti untuk menangani stres yang dialami. Kajian ini dijalankan menggunakan borang soal selidik. Seramai 223 orang pelajar yang berumur antara 19 hingga 22 tahun dijadikan subjek kajian. Alat kajian yang digunakan merangkumi item-item bagi mengukur sumber stres, Adolescent Coping Scale (ACS) bagi mengukur strategi daya tindak dan alat kajian Stress Student Scale yang telah diubahsuai digunakan untuk mengukur stres pelajar. Data yang diperolehi telah dianalisis menggunakan ujian statistik inferensi melibatkan korelasi Pearson dan korelasi separa (partial correlation). Keputusan yang diperolehi menunjukkan terdapat hubungan yang signifikan antara sumber stres keseluruhan dan stres yang dialami pelajar universiti. Sementara itu, strategi daya tindak keseluruhan didapati mampu bertindak sebagai perantara (mediator) bagi hubungan antara sumber stres keseluruhan dan stres yang dialami pelaja

Large scale distribution of total mass versus luminous matter from Baryon Acoustic Oscillations: First search in the SDSS-III BOSS Data Release 10

Baryon Acoustic Oscillations (BAOs) in the early Universe are predicted to leave an as yet undetected signature on the relative clustering of total mass versus luminous matter. A detection of this effect would provide an important confirmation of the standard cosmological paradigm and constrain alternatives to dark matter as well as non-standard fluctuations such as Compensated Isocurvature Perturbations (CIPs). We conduct the first observational search for this effect, by comparing the number-weighted and luminosity-weighted correlation functions, using the SDSS-III BOSS Data Release 10 CMASS sample. When including CIPs in our model, we formally obtain evidence at $3.2\sigma$ of the relative clustering signature and a limit that matches the existing upper limits on the amplitude of CIPs. However, various tests suggest that these results are not yet robust, perhaps due to systematic biases in the data. The method developed in this Letter, used with more accurate future data such as that from DESI, is likely to confirm or disprove our preliminary evidence.Comment: 6 pages, 2 figures, accepted for publication in PR

Decompressive Craniectomy: From option to standard (Part II)

The paper intends an update to the theoretical and practical data on a seldom utilized technique but often considered as last therapeutically option, so the necessity to realize it correctly. In this second part are presented the indications of the technique for each type of pathology, together with the results and latest guideline indications

Layer by layer - Combining Monads

We develop a method to incrementally construct programming languages. Our approach is categorical: each layer of the language is described as a monad. Our method either (i) concretely builds a distributive law between two monads, i.e. layers of the language, which then provides a monad structure to the composition of layers, or (ii) identifies precisely the algebraic obstacles to the existence of a distributive law and gives a best approximant language. The running example will involve three layers: a basic imperative language enriched first by adding non-determinism and then probabilistic choice. The first extension works seamlessly, but the second encounters an obstacle, which results in a best approximant language structurally very similar to the probabilistic network specification language ProbNetKAT

Weak Gravitational Field in Finsler-Randers Space and Raychaudhuri Equation

The linearized form of the metric of a Finsler - Randers space is studied in relation to the equations of motion, the deviation of geodesics and the generalized Raychaudhuri equation are given for a weak gravitational field. This equation is also derived in the framework of a tangent bundle. By using Cartan or Berwald-like connections we get some types "gravito - electromagnetic" curvature. In addition we investigate the conditions under which a definite Lagrangian in a Randers space leads to Einstein field equations under the presence of electromagnetic field. Finally, some applications of the weak field in a generalized Finsler spacetime for gravitational waves are given.Comment: 22 pages, matches version published in GER