sj-docx-1-hpx-10.1177_00185787241229152 – Supplemental material for Cost-effectiveness Analysis of Second-Generation Antihistamine 1 Receptor Blockers and Japanese Kampo Shoseiryuto for Treating Perennial Allergic Rhinitis in Outpatient Settings in Japan

Supplemental material, sj-docx-1-hpx-10.1177_00185787241229152 for Cost-effectiveness Analysis of Second-Generation Antihistamine 1 Receptor Blockers and Japanese Kampo Shoseiryuto for Treating Perennial Allergic Rhinitis in Outpatient Settings in Japan by Naoto Nakagawa, Masami Kashiwabara, Kei Egawa and Ayaka Sasaki in Hospital Pharmacy</p

sj-docx-2-hpx-10.1177_00185787241229152 – Supplemental material for Cost-effectiveness Analysis of Second-Generation Antihistamine 1 Receptor Blockers and Japanese Kampo Shoseiryuto for Treating Perennial Allergic Rhinitis in Outpatient Settings in Japan

Supplemental material, sj-docx-2-hpx-10.1177_00185787241229152 for Cost-effectiveness Analysis of Second-Generation Antihistamine 1 Receptor Blockers and Japanese Kampo Shoseiryuto for Treating Perennial Allergic Rhinitis in Outpatient Settings in Japan by Naoto Nakagawa, Masami Kashiwabara, Kei Egawa and Ayaka Sasaki in Hospital Pharmacy</p

Self-rating Depression Scale and the CRH-BP SNP.

<p>We analyzed associations between the selected SNP (<i>rs10474485</i>) and psychometric scores according to sex. (a) In male subjects, a significant group (IBS/control) × rs10474485 genotype interaction (p = 0.045) was observed. (b) Further, there was a significant group (IBS/control) × <i>rs10474485</i> A allele interaction (p = 0.017). *p <i><</i> 0.05.</p

IBS subtype and CRH-BP SNP.

<p>We analyzed the associations between the SNPs and psychometric scores according to IBS subtype. (a) In individuals with diarrhea-type IBS, <i>rs10474485</i> A allele non-carriers showed higher scores than carriers. There were significant differences in the PSS (p = 0.018) and Trait (p = 0.017) scores. (b) In addition, in the IBS group with mixed symptoms, a significant difference was observed in the SDS score (p = 0.030). There was no significant difference in the constipation group. *p <i><</i> 0.05.</p

Genotype Frequencies in the IBS Patients and Controls.

<p>Genotype Frequencies in the IBS Patients and Controls.</p

Sample Characteristics.

<p>Sample Characteristics.</p

Sex differences in psychometric scores according to the CRH-BP SNP.

<p>(a) In analysis of male subjects (IBS + control), there was no significant difference (SDS, p = 0.864; PSS, p = 0.177; State, p = 0.979; Trait; p = 0.976). (b) In contrast, female A allele non-carriers of <i>rs10474485</i> showed significantly higher PSS (p = 0.028) and State of STAI (p = 0.035) scores and tended to have higher SDS (p = 0.083) and Trait of STAI (p = 0.078) scores than carriers. *p < 0.05.</p

Psychometric Scores.

<p>Psychometric Scores.</p

Perceived stress, depression, and anxiety in controls and IBS patients.

<p>SDS: Self-rating Depression Scale, PSS: Perceived Stress Scale,</p><p>STAI: StateTrait Anxiety Inventory.</p

IBS subtype (bowel pattern) in relation to TAT haplotype copy number and sex.

<p>IBS subtype: C, constipation; M, mixed; D, diarrhea.</p