35 research outputs found

    Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

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    Clinical features and natural history of coronavirus disease 2019 (COVID-19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality rate (CFR) and to identify predictors of mortality in a cohort of COVID-19 patients admitted to three hospitals of Northern Italy between March 1 and April 28, 2020. All these patients had a confirmed diagnosis of SARS-CoV-2 infection by molecular methods. During the study period 504/1697 patients died; thus, overall CFR was 29.7%. We looked for predictors of mortality in a subgroup of 486 patients (239 males, 59%; median age 71 years) for whom sufficient clinical data were available at data cut-off. Among the demographic and clinical variables considered, age, a diagnosis of cancer, obesity and current smoking independently predicted mortality. When laboratory data were added to the model in a further subgroup of patients, age, the diagnosis of cancer, and the baseline PaO2/FiO2 ratio were identified as independent predictors of mortality. In conclusion, the CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID-19 pandemic approached 30%. The identification of mortality predictors might contribute to better stratification of individual patient risk

    Determination of metals in the Spirulina Platensis by instrumental neutron activation analysis

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    in: Radiations: from theory to multidisciplinary applications, A. Salvadori (Ed.

    Determination of organophosphorus pesticide residues in human tissues by capillary gas chromatography-negative chemical ionization mass spectrometry analysis

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    Simultaneous determination of cysteine, cysteine and 18 other amino acids in varius matrices by high-performance liquid chromatography

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    Free and total amino acid composition in blue-green algae

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    The first investigation on PM10 and SO2 levels in an Iranian megacity, Isfahan, and a relative comparison with Rome

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