Empyema Thoracis in Zaria; a Preliminary Report

Aims and ObjectiveTo study the nature and pattern of presentation of empyema thoracis (and the association between duration or time of presentation and educational level and level of income respectively), the aetiology, and different treatment outcomes.                                                                Materials and MethodsA prospective study of all patients who presented with Empyema Thoracis between January 2008 to May 2010 was carried out at ABUTH Zaria. Thediagnosis of empyema thoracis was entertained from either the presence of pus in the pleural space or the culture of actively multiplying bacteria in a serous Data was analysed with SPSS 15.ResultsA total of 26 patients were managed, 19(73.1%) men, 7(26.9%) women. There were 4(15.4%) acute and 22(84.6%) chronic empyema. One male had bilateral chronic empyema giving 13 right-sided, and 14 left-sided empyema. Tuberculosis was responsible for 26.9% of the cases, 38.4% were postpneumonic, while postoperative, and AIDS were each responsible for 11.5% and trauma 7.7%. Five patients had decortication, 2 had rib resection and open drainage, and the remainder were managed on tube thoracostomy. Two patients were discharged against medical advice, 6 were lost during follow-up. Fourteen (53.8%) were educated (1 acute and 13 chronic). Twelve (46.2 %) were uneducated (3 acute and 9 chronic). Fourteen patients (2 acute and 12 chronic) earned average or above average income while 12 (46.2%) earned below average income (2 acute and 10 chronic). There was no association between duration of presenting complaints and level of education or level of income (Fisher's exact test was, 0.306 and 1.000, respectively) at a P value of 0.05.                          ConclusionEmpyema thoracis is persistent and prevalent in our environment despite improvements in diagnosis, treatment and prevention. Most patients present late and this is not related to income or level of education. The commonest organism isolated from empyema fluid in developing countries is Staphylococcus aureus but most empyema fluid are sterile due to prolong antibiotic use. The factors responsible for delayed presentation, the pattern of presentation and the pathology and outcome of treatment is part of an ongoing study.Key Words: Empyema Thoracis, Presentation, Aetiology, Treatmen

Fertility Status of Fadama Soils in Gantsare Village, Wamakko Local Government, Sokoto State As Affected by Cement Dust

A study was conducted in Gantsare village, Wamakko local government, Sokoto state to determine the effect of cement dust emitted from Sokoto cement factory on the fertility of fadama soils. Soil samples were collected in June, 2008 from the eastern, northeastern, and southeastern parts of the village and Girabshi; a nearby village with least effect of the dust. The samples were collected at two depths (0-15 and 15-30 cm) using simple random sampling method. Randomized complete block design (RCBD) was employed, replicated three times, making a total of 24 samples. The samples were analyzed for pH, OC, CEC, total N, available P, exchangeable bases (Ca, Mg, K and Na) and particle size. Almost all parameters determined were found to be statistically significant (P < 0.01). OC was found to be lower in concentration in the areas closer to the factory; eastern part6.25 respectively, likewise CEC and exchangeable bases. The trend in the results observed may be attributed to possible adverse effects of the dust on microbial population, reduction in the availability of some nutrients and a favour on the concentrations of exchangeable bases and CEC. The topsoils showed better results of all the soil chemical properties. The study recommends minimization of the amount of dust reaching agricultural soils and the use of phosphorus and nitrogen fertilizer supplements as soil management practices to enhance soil fertility status and enhance adequate crop yield in the area. Key words:Cement dust, fertility status, fadama soils, soil chemical properties, soil management

Ipomea asarifolia (Desr), A Potential Cover Crop for Soil Fertility Improvement in The Sudan Savanna Region, Nigeria

The effect of Ipomea asarifolia on physico - chemical properties of the soils at Usmanu Danfodiyo University, Sokoto main campus, in the Sudan Savanna of Nigeria was investigated. The study determined the effect of the plant on some physical and chemical properties of soils, found out the nutrient retention ability of the plant in the soils and the variation of the effect with distance within the plants’ canopy. A total of 48 samples were collected from four different sites within Usmanu Danfodiyo University main Campus; VC complex area, University stadium area, Behind new library area and opposite IBB centre area and four distances from the plant (control, plant base, 0.5 m and 1 m from the plant base). Samples were collected for use in a randomized complete block design (RCBD) experiment with three replicates. Soil pH, Organic C, CEC, total N, available P, K, Ca and Mg concentrations were determined, particle size analysis was also carried out. The results were subjected to analysis of variance (ANOVA), where significant F values were obtained, the means were separated by Duncan multiple range tests (DMRT). The difference among the sites and the distances were found to be statistically significant (P VC complex area > New library area > IBB centre area. On the other hand, the effect on all the parameters was found to decrease with distance from the plant with the base of the plant having the highest organic C, CEC, total N, available P and exchangeable K, Ca and Mg; 6.83 g kg-1, 5.00 cmol kg-1, 0.42 g kg-1, 10.82 mg kg-1 and 0.26, 0.50 and 0.97 cmol kg-1 respectively, while the control soils had the least values; 3.46 g kg-1, 4.00 cmol kg-1, 0.12 g kg-1, 7.43 mg kg-1, 0.21, 0.38, and 0.45 cmol kg-1 respectively. The effect was attributed to the accumulation of organic matter around the plant and its ability to prevent erosion by both water and wind thus retaining nutrients making it a suitable cover crop for soil fertility improvement

Validation of xMAP SARS-CoV-2 Multi-Antigen IgG assay in Nigeria

Objective: There is a need for reliable serological assays to determine accurate estimates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence. Most single target antigen assays have shown some limitations in Africa. To assess the performance of a multi-antigen assay, we evaluated a commercially available SARS-CoV-2 Multi-Antigen IgG assay for human coronavirus disease 2019 (COVID-19) in Nigeria. / Methods: Validation of the xMAP SARS-CoV-2 Multi-Antigen IgG assay was carried out using well-characterized SARS-CoV-2 reverse transcription polymerase chain reactive positive (97) and pre-COVID-19 pandemic (86) plasma panels. Cross-reactivity was assessed using pre-COVID-19 pandemic plasma specimens (213) from the 2018 Nigeria HIV/AIDS Indicator and Impact Survey (NAIIS). / Results: The overall sensitivity of the xMAP SARS-CoV-2 Multi-Antigen IgG assay was 75.3% [95% CI: 65.8%– 82.8%] and specificity was 99.0% [95% CI: 96.8%– 99.7%]. The sensitivity estimate increased to 83.3% [95% CI: 70.4%– 91.3%] for specimens >14 days post-confirmation of diagnosis. However, using the NAIIS pre-pandemic specimens, the false positivity rate was 1.4% (3/213). / Conclusions: Our results showed overall lower sensitivity and a comparable specificity with the manufacturer’s validation. There appears to be less cross-reactivity with NAIIS pre-pandemic COVID-19 specimens using the xMAP SARS-CoV-2 Multi-Antigen IgG assay. In-country SARS-CoV-2 serology assay validation can help guide the best choice of assays in Africa

Comparative evaluation of protein and amino acid composition of melon (Citrullus vulgaris) and watermelon (Citrullus lanatus) seeds

The seeds of melon (Citrullus vulgaris) and water melon (Citrullus lanatus) from Nasarawa town in Nasarawa State and Shagari town in Sokoto State, Nigeria were respectively analyzed for their crude protein and amino acids contents. The crude protein compositions of the melon and water melon seeds were found to be 30.2% and 24.23% respectively. The results of the amino acids analyses indicated that both the melon and the water melon seeds were rich in aspartic and glutamic acids (7.99 and 15.16 g/100g of protein respectively) and were also good sources of five out of seven categories of essential amino acids analyzed, with chemical scores of 5/8. eucine was also present in fairly high (7.17g/100g of proteins) Leucine was also present in fairly high (7.17 g/100g of proteins). Methionine was the most limiting essential amino acids in the seed samples. These results serve as information for harnessing the nutritional potential of both melon and water melon seeds.Keywords: Protein, amino acids, melon, water melon, nutritionInternational Journal of Natural and Applied Sciences, 5(3): 208-212, 200

Health systems readiness and quality of inpatient malaria case-management in Kano State, Nigeria

Background Nigeria was among the first African countries to adopt and implement change of treatment policy for severe malaria from quinine to artesunate. Seven years after the policy change health systems readiness and quality of inpatient malaria case-management practices were evaluated in Kano State of Nigeria. Methods A cross-sectional survey was undertaken in May 2019 at all public hospitals. Data collection comprised hospital assessments, interviews with inpatient health workers and data extraction from medical files for all suspected malaria patients admitted to the paediatric and medical wards in April 2019. Descriptive analyses included 22 hospitals, 154 health workers and 1,807 suspected malaria admissions analysed from malaria test and treat case-management perspective. Results 73% of hospitals provided malaria microscopy, 27% had rapid diagnostic tests and 23% were unable to perform any parasitological malaria diagnosis. Artemisinin-based combination therapy (ACT) was available at 96% of hospitals, artemether vials at 68% while injectable quinine and artesunate were equally stocked at 59% of hospitals. 32%, 21% and 15% of health workers had been exposed to relevant trainings, guidelines and supervision respectively. 47% of suspected malaria patients were tested while repeat testing was rare (7%). 60% of confirmed severe malaria patients were prescribed artesunate. Only 4% of admitted non-severe test positive cases were treated with ACT, while 76% of test negative patients were prescribed an anti-malarial. Artemether was the most common anti-malarial treatment for non-severe test positive (55%), test negative (43%) and patients not tested for malaria (45%). In all categories of the patients, except for confirmed severe cases, artemether was more commonly prescribed for adults compared to children. 44% of artesunate-treated patients were prescribed ACT follow-on treatment. Overall compliance with test and treat policy for malaria was 13%. Conclusions Translation of new treatment policy for severe malaria into inpatient practice is compromised by lack of malaria diagnostics, stock-outs of artesunate and suboptimal health workers’ practices. Establishment of the effective supply chain and on-going supportive interventions for health workers accompanied with regular monitoring of the systems readiness and clinical practices are urgently needed.</p