The 727 airplane target thrust reverser static performance model test for refanned JT8D engines

The results of a scale model static performance test of target thrust reverser configurations for the Pratt and Whitney Aircraft JT8D-100 series engine are presented. The objective of the test was to select a series of suitable candidate reverser configurations for the subsequent airplane model wind tunnel ingestion and flight controls tests. Test results indicate that adequate reverse thrust performance with compatible engine airflow match is achievable for the selected configurations. Tapering of the lips results in loss of performance and only minimal flow directivity. Door pressure surveys were conducted on a selected number of lip and fence configurations to obtain data to support the design of the thrust reverser system

Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila

During Drosophila oogenesis the expression of the sulfotransferase Pipe in ventral follicle cells is crucial for dorsoventral axis formation. Pipe modifies proteins that are incorporated in the ventral eggshell and activate Toll signaling which in turn initiates embryonic dorsoventral patterning. Ventral pipe expression is the result of an oocyte-derived EGF signal which down-regulates pipe in dorsal follicle cells. The analysis of mutant follicle cell clones reveals that none of the transcription factors known to act downstream of EGF signaling in Drosophila is required or sufficient for pipe regulation. However, the pipe cis-regulatory region harbors a 31-bp element which is essential for pipe repression, and ovarian extracts contain a protein that binds this element. Thus, EGF signaling does not act by down-regulating an activator of pipe as previously suggested but rather by activating a repressor. Surprisingly, this repressor acts independent of the common co-repressors Groucho or CtBP

Roles, Stacks, Histories: A Triple for Hoare

Behavioural type and effect systems regulate properties such as adherence to object and communication protocols, dynamic security policies, avoidance of race conditions, and many others. Typically, each system is based on some specific syntax of constraints, and is checked with an ad hoc solver. Instead, we advocate types refined with first-order logic formulas as a basis for behavioural type systems, and general purpose automated theorem provers as an effective means of checking programs. To illustrate this approach, we define a triple of security-related type systems: for role-based access control, for stack inspection, and for history-based access control. The three are all instances of a refined state monad. Our semantics allows a precise comparison of the similarities and differences of these mechanisms. In our examples, the benefit of behavioural type-checking is to rule out the possibility of unexpected security exceptions, a common problem with code-based access control

Regulation and function of capicua in mammals

Capicua (CIC) is an evolutionarily conserved transcription factor. CIC contains a high-mobility group (HMG) box that recognizes specific DNA sequences to regulate the expression of various target genes. CIC was originally identified in Drosophila melanogaster as a transcriptional repressor that suppresses the receptor tyrosine kinase signaling pathway. This molecule controls normal organ growth and tissue patterning as well as embryogenesis in Drosophila. Recent studies have also demonstrated its extensive functions in mammals. For example, CIC regulates several developmental and physiological processes, including lung development, abdominal wall closure during embryogenesis, brain development and function, neural stem cell homeostasis, T cell differentiation, and enterohepatic circulation of bile acids. CIC is also associated with the progression of various types of cancer and neurodegeneration in spinocerebellar ataxia type-1, systemic autoimmunity, and liver injury. In this review, I provide a broad overview of our current understanding of the regulation and functions of CIC in mammals and discuss future research directions. Gene regulation: The role of the capicua protein in mammals A gene-regulating protein named capicua, first discovered in fruit flies, is being increasingly implicated in important roles in the early development and adult physiology of mammals. Capicua is a transcription factor, a protein that binds to specific locations in DNA and influences the rate at which genetic information is used by a cell to make RNA molecules and proteins. Yoontae Lee at Pohang University of Science and Technology in South Korea reviews current understanding of the role of capicua in mammals. Key processes that have been linked to its activity include the development of lungs, nerves, the brain and the immune system. It also influences the progression of various diseases, and has an apparent tumor-suppressing effect in cancer. Future research should focus on understanding capicua's mechanism of action and its significance in human disease.11Ysciescopuskc