Thermochemical Studies of Epoxides and Related Compounds

Gas-phase heats of formation for the four butene oxide isomers are reported. They were obtained by measuring the condensed-phase heat of reduction to the corresponding alcohol using reaction calorimetry. Heats of vaporization were determined and allow gas-phase heats of formation to be obtained. The experimental measurements are compared to calculations obtained using a variety of computational methods. Overall, the G3 and CBS-APNO methods agree quite well with the experimental data. The influence of alkyl substituents on epoxide stability is discussed. Comparisons to alkenes, cyclopropanes, aziridines, thiiranes, and phosphiranes are also made. Isodesmic-type reactions were used to determine strain energies of the epoxides and related compounds with various substituents

Additional file 1: of Fish oil supplementation in chronic obstructive pulmonary disease: feasibility of conducting a randomised controlled trial

CONSORT 2010 checklist of information to include when reporting a randomised trial. (DOCX 36 kb