Novel 2‑Aminobenzamides as Potential Orally Active Antithrombotic Agents

In an effort to develop potent antithrombotic agents, a series of novel 2-aminobenzamide derivatives were synthesized and screened for their in vivo antithrombotic activity. Among the 23 compounds tested, compound (<b>8g</b>) showed the most promising antithrombotic activity, which was comparable with clinically used aspirin or warfarin, but at variance with these standard drugs, <b>8g</b> did not exhibit the increased bleeding time, suggesting its potential as a novel antithrombotic agent