Counties included in the European Regional Development Fund INTERREG Ireland Wales programme area.

<p>Counties included in the European Regional Development Fund INTERREG Ireland Wales programme area.</p

Importance of neuroimaging for the diagnosis of dementia.

<p>Importance of neuroimaging for the diagnosis of dementia.</p

Importance of furthering knowledge about neuroimaging in dementia.

<p>Importance of furthering knowledge about neuroimaging in dementia.</p

Confidence in selecting the most appropriate neuroimaging modality.

<p>Confidence in selecting the most appropriate neuroimaging modality.</p

Reported availability of neuroimaging modalities for direct referral.

<p>Reported availability of neuroimaging modalities for direct referral.</p

Diffusional changes in MCI subjects for FA and MD.

<p>(a) Significantly higher FA in MCIna relative to controls is shown in green. (b) Significantly higher MD in MCIa relative to controls is shown in red.</p

ROC curve for control, MCIna and MCIa classification.

<p>True positives refer to MCIa volumes that are correctly classified as MCIa, and false positives refer to volumes that are incorrectly labelled as MCIa.</p

Sex differences for absolute grey and white matter volumes in control and MCI subjects.

<p>(A) Absolute male control WM volume is significantly larger than absolute female control white matter volume. Absolute male control WM volume is also significant larger than absolute female MCI WM volume. (B) Absolute male control GM volume is significantly larger than absolute female control grey matter volume. Absolute male control GM volume is also significant larger than absolute female MCI WM volume. *p<0.05, **p<0.01, *** p<0.001, with post-hoc Tukey test, following an ANOVA.</p

Summary of Results Obtained with TBSS with all 4 indices.

<p>The total volume of significant voxels for each contrast is given in mm³. Results are calculated on the total volume of voxels remaining in each contrast at a significance level of p<0.05, corrected for multiple comparisons with family wise error comparison. x = no significant result. CON; Control, MCIna; non-amnestic MCI; MCIa; amnestic MCI. Each contrast is denoted by “:”; i.e. CON:MCIna refers to the control versus MCIna contrast.</p

Grey matter and white matter volume decline with age.

<p>An ANOVA model with normalised GM volume as the dependent variable and age, sex and diagnosis as the independent variables, returned a significant main effect of age, and no significant interactions. Here, a regression line for GM decline with age (including men and women) is plotted (left). An ANOVA model with normalised WM volume as the dependent variable and age, sex and diagnosis as the independent variables, also returned a significant main effect of age, with no significant interactions. A regression line for WM decline with age (including men and women) is plotted (right). The r value denotes the correlation as calculated by Pearson’s product-moment correlation using data from all subjects. Correlations are significant as indicated by the p values.</p