Topological Indices Polynomials of Domination David Derived Networks

ترتبط الخصائص الكيميائية للمركبات الكيميائية وبنيتها الجزيئية ارتباطًا وثيقًا.  المؤشرات الطوبولوجية هي قيم عددية مرتبطة بالرسوم البيانية الجزيئية الكيميائية التي تساعد في فهم الخصائص الفيزيائية والكيميائية والتفاعل الكيميائي والنشاط البيولوجي للمركب الكيميائي. يتطرق هذا البحث على بعض الخصائص الطوبولوجية للشبكات المشتقة من  dominating David derived وتحصي العديد من K Banhatti  متعدد الحدود من النوع الثاني والثالث من DDD.The chemical properties of chemical compounds and their molecular structures are intimately connected. Topological indices are numerical values associated with chemical molecular graphs that help in understanding the physicochemical properties, chemical reactivity and biological activity of a chemical compound. This study obtains some topological properties of second and third dominating David derived (DDD) networks and computes several K Banhatti polynomial of second and third type of DDD

Some K-Banhatti Polynomials of First Dominating David Derived Networks

            ترتبط المركبات الكيميائية والخصائص والتراكيب الجزيئية إرتباطا حتمياً. إن المؤشرات التبولوجية هي عبارة عن قيم عددية مرتبطة بالرسوم البيانية الجزيئية الكيميائية التي تساهم في فهم الصفات الفيزيائية للمركب الكيميائي والتفاعل الكيميائي والنشاط البيولوجي. في هذه الدراسة، تم الحصول على بعض الخواص التبولوجية لشبكات مشتقة ديفيد الأولى المهيمنة, وحساب العديد من ممتعددات حدود K-Banhatti من النوع الأول من شبكات مشتقة  ديفيد الأولى المهيمنة.Chemical compounds, characteristics, and molecular structures are inevitably connected. Topological indices are numerical values connected with chemical molecular graphs that contribute to understanding a chemical compounds physical qualities, chemical reactivity, and biological activity. In this study, we have obtained some topological properties of the first dominating David derived (DDD) networks and computed several K-Banhatti polynomials of the first type of DDD

An overlooked connection: serotonergic mediation of estrogen-related physiology and pathology

BACKGROUND: In humans, serotonin has typically been investigated as a neurotransmitter. However, serotonin also functions as a hormone across animal phyla, including those lacking an organized central nervous system. This hormonal action allows serotonin to have physiological consequences in systems outside the central nervous system. Fluctuations in estrogen levels over the lifespan and during ovarian cycles cause predictable changes in serotonin systems in female mammals. DISCUSSION: We hypothesize that some of the physiological effects attributed to estrogen may be a consequence of estrogen-related changes in serotonin efficacy and receptor distribution. Here, we integrate data from endocrinology, molecular biology, neuroscience, and epidemiology to propose that serotonin may mediate the effects of estrogen. In the central nervous system, estrogen influences pain transmission, headache, dizziness, nausea, and depression, all of which are known to be a consequence of serotonergic signaling. Outside of the central nervous system, estrogen produces changes in bone density, vascular function, and immune cell self-recognition and activation that are consistent with serotonin's effects. For breast cancer risk, our hypothesis predicts heretofore unexplained observations of the opposing effects of obesity pre- and post-menopause and the increase following treatment with hormone replacement therapy using medroxyprogesterone. SUMMARY: Serotonergic mediation of estrogen has important clinical implications and warrants further evaluation

Preparation and evaluation of the cytotoxic nature of TiO2 nanoparticles by direct contact method

M Chellappa,1 U Anjaneyulu,1 Geetha Manivasagam,2 U Vijayalakshmi1 1School of Advanced Sciences, Materials Chemistry Division, 2Centre for Biomaterials Science and Technology, School of Mechanical and Building Sciences, VIT University, Vellore, Tamil Nadu, India Abstract: The purpose of this study is to prepare and evaluate the effect of synthesized titanium dioxide (TiO2) nanoparticles for their biocompatibility on physiological body fluids and the effect of cell toxicity to produce osteointegration when used as implantable materials. For the past few decades, the number of researches done to understand the importance of the biocompatibility of bioceramics, metals, and polymers and their effect on clinical settings of biomedical devices has increased. Hence, the total concept of biocompatibility encourages researchers to actively engage in the investigation of the most compatible materials in living systems by analyzing them using suitable physical, chemical, and biological (bioassay) methods. The ceramic material nano TiO2 was prepared by sol-gel method and analyzed for its functional group and phase formation by Fourier transform infrared spectroscopy and powder X-ray diffraction. Furthermore, the particle size, shape, surface topography, and morphological behavior were analyzed by dynamic light scattering, zeta potential, scanning electron microscopy–energy dispersive X-ray analysis, and transmission electron microscopy analysis. In addition to this, the cytotoxicity and cytocompatibility were determined on MG63 cell lines with varying doses of concentrations such as 1 µg/mL, 10 µg/mL, 25 µg/mL, 50 µg/mL, and 100 µg/mL with different time periods such as 24 hours and 48 hours. The results have not shown any toxicity, whereas, it improved the cell viability/proliferation at various concentrations. Hence, these findings indicate that the nano TiO2 material acts as a good implantable material when used in the biomedical field as a prime surface-modifying agent. Keywords: biomaterial, implant, biocompatible, MTT assay, osteointegration, MG63 cell line