Learning theories reveal loss of pancreatic electrical connectivity in diabetes as an adaptive response

Cells of almost all solid tissues are connected with gap junctions which permit the direct transfer of ions and small molecules, integral to regulating coordinated function in the tissue. The pancreatic islets of Langerhans are responsible for secreting the hormone insulin in response to glucose stimulation. Gap junctions are the only electrical contacts between the beta-cells in the tissue of these excitable islets. It is generally believed that they are responsible for synchrony of the membrane voltage oscillations among beta-cells, and thereby pulsatility of insulin secretion. Most attempts to understand connectivity in islets are often interpreted, bottom-up, in terms of measurements of gap junctional conductance. This does not, however explain systematic changes, such as a diminished junctional conductance in type 2 diabetes. We attempt to address this deficit via the model presented here, which is a learning theory of gap junctional adaptation derived with analogy to neural systems. Here, gap junctions are modelled as bonds in a beta-cell network, that are altered according to homeostatic rules of plasticity. Our analysis reveals that it is nearly impossible to view gap junctions as homogeneous across a tissue. A modified view that accommodates heterogeneity of junction strengths in the islet can explain why, for example, a loss of gap junction conductance in diabetes is necessary for an increase in plasma insulin levels following hyperglycemia.Comment: 15 pages, 5 figures. To appear in PLoS One (2013

Spin-models of granular compaction: From one-dimensional models to random graphs

We discuss two athermal types of dynamics suitable for spin-models designed to model repeated tapping of a granular assembly. These dynamics are applied to a range of models characterised by a 3-spin Hamiltonian aiming to capture the geometric frustration in packings of granular matter.Comment: Contribution to "Challenges in Granular Media", ICTP Trieste; to appear in 'Advances in Complex Systems

A column of grains in the jamming limit: glassy dynamics in the compaction process

We investigate a stochastic model describing a column of grains in the jamming limit, in the presence of a low vibrational intensity. The key control parameter of the model, $\epsilon$, is a representation of granular shape, related to the reduced void space. Regularity and irregularity in grain shapes, respectively corresponding to rational and irrational values of $\epsilon$, are shown to be centrally important in determining the statics and dynamics of the compaction process.Comment: 29 pages, 14 figures, 1 table. Various minor changes and updates. To appear in EPJ