James Mann, M.D. (1759-1832): Military Surgeon for the Second War of Independence .

The War of 1812 is remembered for the Burning of Washington, and Francis Scott Key’s “The Star Spangled Banner,” but little else. It was a poorly funded war of relatively short duration and nebulous resolution. Under such circumstances, it is understandable that the “Second War of Independence” failed to produce many notable military or medical advancements. However, one surgeon took it upon himself to recount his experiences in the field. For his dedication to the art and science of medicine, James Mann deserves recognition

Towards a conservation plan for the Cape Griffon Gyps coprotheres: identifying priorities for research and conservation

No Abstract. Vulture News Vol. 57 2007: pp. 56-5

From Macrocycles to Quantum Rings: Does Aromaticity Have a Size Limit?

ConspectusThe ring currents of aromatic and antiaromatic molecules are remarkable emergent phenomena. A ring current is a quantum-mechanical feature of the whole system, and its existence cannot be inferred from the properties of the individual components of the ring. Hückel's rule states that when an aromatic molecule with a circuit of [4n + 2] πelectrons is placed in a magnetic field, the field induces a ring current that creates a magnetic field opposing the external field inside the ring. In contrast, antiaromatic rings with 4n πelectrons exhibit ring currents in the opposite direction. This rule bears the name of Erich Hückel, and it grew from his molecular orbital theory, but modern formulations of Hückel's rule incorporate contributions from others, particularly William Doering and Ronald Breslow. It is often assumed that aromaticity is restricted to small molecular rings with up to about 22 πelectrons. This Account outlines the discovery of global ring currents in large macrocycles with circuits of up to 162 πelectrons. The largest aromatic rings yet investigated are cyclic porphyrin oligomers, which exhibit global ring currents after oxidation, reduction or optical excitation but not in the neutral ground state. The global aromaticity in these porphyrin nanorings leads to experimentally measurable aromatic stabilization energies in addition to magnetic effects that can be studied by NMR spectroscopy. Wheel-like templates can be bound inside these nanorings, providing excellent control over the molecular geometry and allowing the magnetic shielding to be probed inside the nanoring. The ring currents in these systems are well-reproduced by density functional theory (DFT), although the choice of DFT functional often turns out to be critical. Here we review recent contributions to this field and present a simple method for determining the ring current susceptibility (in nA/T) in any aromatic or antiaromatic ring from experimental NMR data by classical Biot-Savart calculations. We use this method to quantify the ring currents in a variety of aromatic rings. This survey confirms that Hückel's rule reliably predicts the direction of the ring current, and it reveals that the ring current susceptibility is surprisingly insensitive to the size of the ring. The investigation of aromaticity in even larger molecular rings is interesting because ring currents are also observed when mesoscopic metal rings are placed in a magnetic field at low temperatures. The striking similarity between the ring currents in molecules and mesoscopic metal rings arises because the effects have a common origin: a field-dependent phase shift in the electronic wave function. The main difference is that the magnetic flux through mesoscopic rings is much greater because of their larger areas, so their persistent currents are nonlinear and oscillatory with the applied field, whereas the flux through aromatic molecules is so small that their response is approximately linear in the applied field. We discuss how nonlinearity is expected to emerge in large molecular nanorings at high magnetic fields. The insights from this work are fundamentally important for understanding aromaticity and for bridging the gap between chemistry and mesoscopic physics, potentially leading to new functions in molecular electronics

Optical Sensors for Direct Measurements in Chemical Processes

The benefit of employing continuous, and ideally, non-destructive analysis during chemical manufacturing processes is widely recognized as providing very high rates of return to industry. As markets become increasingly more competitive, feedstocks more costly, and environmental issues escalate, the need for robust, stable, and affordable on-line process analysis systems continues to grow. Among the possible technologies employed in these process applications, optical methods are frequently used. The University of Washington Center for Process Analytical Chemistry (CPAC) has had a core effort in the investigation of sensor systems based on optical waveguide technology since its founding in 1984. These efforts have been broadly based, involving both the use of non-invasive direct optical analysis for species or parameter identification and the investigation of minimally invasive extractive approaches utilizing reagent chemistries. This work is further leveraged through strong interactions with another core CPAC program focusing on the development and use of chemometric multivatiate data analysis techniques. The three examples presented below: fiber optic evanescent wave spectroscopy using extractive coatings, the use of integrated grating and waveguide structures, and applications of low coherence high precision reflectometry for process monitoring, represent on-going optical sensor work at CPAC and demonstrate the synergy between this program and chemometrics

Simulated spinal cerebrospinal fluid leak repair: an educational model with didactic and technical components.

BACKGROUND: In the era of surgical resident work hour restrictions, the traditional apprenticeship model may provide fewer hours for neurosurgical residents to hone technical skills. Spinal dura mater closure or repair is 1 skill that is infrequently encountered, and persistent cerebrospinal fluid leaks are a potential morbidity. OBJECTIVE: To establish an educational curriculum to train residents in spinal dura mater closure with a novel durotomy repair model. METHODS: The Congress of Neurological Surgeons has developed a simulation-based model for durotomy closure with the ongoing efforts of their simulation educational committee. The core curriculum consists of didactic training materials and a technical simulation model of dural repair for the lumbar spine. RESULTS: Didactic pretest scores ranged from 4/11 (36%) to 10/11 (91%). Posttest scores ranged from 8/11 (73%) to 11/11 (100%). Overall, didactic improvements were demonstrated by all participants, with a mean improvement between pre- and posttest scores of 1.17 (18.5%; P = .02). The technical component consisted of 11 durotomy closures by 6 participants, where 4 participants performed multiple durotomies. Mean time to closure of the durotomy ranged from 490 to 546 seconds in the first and second closures, respectively (P = .66), whereby the median leak rate improved from 14 to 7 (P = .34). There were also demonstrative technical improvements by all. CONCLUSION: Simulated spinal dura mater repair appears to be a potentially valuable tool in the education of neurosurgery residents. The combination of a didactic and technical assessment appears to be synergistic in terms of educational development

Moyamoya: A Review of the Disease and Current Treatments

INTRODUCTION Moyamoya disease is a rare progressive cerebrovascular disease characterized by bilateral stenosis of vasculature of the Circle of Willis, specifically the distal internal carotid arteries, that leads to extensive collateral circulation. These dilated collateral vessels are described as having a hazy “puff of smoke” appearance on angiography. “Moyamoya” is the Japanese word for this characteristic appearance. The disease was originally described in Japan in 1957 1 and introduced to the English literature in 1969.2 The disease is most known for its distribution in Asian populations, but recently there has been more research and attention given to moyamoya in Europe and North American Moyamoya disease presents clinically due to the ischemic and hemorrhagic complications of abnormal cerebral vascularity.3,4 Epidemiology Moyamoya disease was originally described in Japanese populations but is present in a variety of ethnicities.3,5,6 In Japan, the incidence per 100,000 patient years is between 0.35 to 0.943 with a male: female ratio of 1:1.87. In the US, incidence ranged from 0.05 to 0.17 per 100,000 patient years with a similar gender distribution.3,6 Other population studies have not been as robust but European studies show moyamoya statistics that are more similar to American findings than those of Asian moyamoya findings.4 There is a bimodal distribution of incidence: in early childhood and adulthood, but the doublepeaked incidence is less dramatic in the US and Europe.4,8 Children typically present with the ischemic symptoms and adults can present with either ischemic or hemorrhagic type, with the ischemic type predominating.5,9 Overall, the hemorrhagic type is more common in Asia than the U.S.9 The incidence has been increasing with time, which may be due to increased awareness.

Identifying Women with Coronary Artery Disease using non-cardiac CT Imaging

Aims Identify the percentage of female patients with prior CT scans done for noncardiac reasons who should have the diagnosis of CAD. Collaborate with primary care, cardiology and breast imaging to determine how best to integrate this incidental finding into clinical practice. Determine current barriers that may prevent providers from taking action on patients with new CAD

Ventilation Method during Intensive Care Unit Transport after Cardiac Surgeries; When Should We Use A Ventilator?

Background Problem Statement: Manual ventilation with AMBU bag is utilized mostly for transporting post cardiac surgery patients to the intensive care unit, but some patients need mechanical ventilation due to concern for oxygenation, ventilation, and cardiac function. Also, transport can be a critical moment because of limited hemodynamic information and suboptimal environment for therapeutic intervention. Thus, risk stratification for appropriate ventilation is necessary for safe transport. • Project AIM: We assessed biventricular function (with a hand-held echocardiography), arterial blood gas, and hemodynamics pre and post transport in manual and mechanical ventilation groups