15 research outputs found
Key mutations in the C-terminus of the HBV surface glycoprotein correlate with lower HBsAg levels in vivo, hinder HBsAg secretion in vitro and reduce HBsAg structural stability in the setting of HBeAg-negative chronic HBV genotype-D infection
Liver Fibrosis Markers Improve Prediction of Outcome in NonâAcetaminophenâAssociated Acute Liver Failure
The effect of intraoperative autofluorescence monitoring on unintentional parathyroid gland excision rates and postoperative PTH concentrationsâa single-blind randomized-controlled trial
Baseline IL-2 and the AIH score can predict the response to standard therapy in paediatric autoimmune hepatitis
Pioglitazone is effective for multiple phenotyepes of the Zucker fa/fa rat with polycystc ovary morphology and insulin resistance
An Indirect Action Contributes to C-Fos Induction in Paraventricular Hypothalamic Nucleus by Neuropeptide Y
Accuracy of M2BPGi, compared with Fibro ScanÂź, in analysis of liver fibrosis in patients with hepatitis C
The utility of biomarkers in prognosis assessment of patients with acute liver failure
Background: Acute liver failure (ALF) is a rare but potential lethal condition characterized by the sudden development of jaundice, coagulopathy and hepatic encephalopathy in patients without underlying liver disease. In selected patients, emergency liver transplantation is required. Selection of these patients is based on clinical criteria such as the Kings College Criteria (KCC) or the Clichy criteria.
Aims: The aim of this work is to provide an overview of potential biomarkers that could improve the prognostic value of KCC.
Results: Several promising biomarkers involved in related pathophysiological processes have been identified. Some could be as stand-alone biomarkers; however, the best prognostic values have been observed in the combination of biomarkers with current models. Among these, the ALFSG Index that combines clinical parameters and circulating blood levels of CK18 claims a higher prognostic value than KCC.
Conclusions: In this review, all potential biomarkers for ALF have been summarized to give an overview of the work performed over the last years, and a glimpse of what to expect in this field in the coming years