Microvessel density relation to HIF1α expression and local disease relapse in operated and irradiated patients.

<p>Microvessel density relation to HIF1α expression and local disease relapse in operated and irradiated patients.</p

HIF1α expression association with the status alive or local disease relapse.

<p>HIF1α expression association with the status alive or local disease relapse.</p

Local disease-free survival relation to HIF1α expression.

<p>High HIF1α expression is related to an increased local disease-free survival.</p

Correlation of tumor epidemiological and pathological features with HIF1α expression.

*<p>TNM classification (3^rd edition).</p

HIF1α expression and specific or local disease-free survival after treatment.

<p>Considering surgical (S) treatment only, high HIF1α expression predicts local disease-free survival. Considering surgery plus radiotherapy (S+RT), high HIF1α expression predicts both specific and local disease-free survival.</p

Multivariate analysis of the relationship between clinical and pathological tumor features with gene polymorphism and FGFR4 expression.

a, b<p>Values adjusted by multivariate logistic regression.</p><p>For Gly388Arg and FGFR4 expression correlation with lymphatic embolization and lymph node status, tumor size and differentiation status were considered in the multivariate analysis. For disease relapse and disease specific death, tumor size, lymph node status and radiotherapy treatment were considered.</p

Survival plots.

<p>a. and b.: Disease-free survival and disease specific survival according to FGFR4 Gly388Arg polymorphism; c. and d.: Disease-free survival and disease specific survival according to FGFR4 expression; e. and f.: Disease-free survival and disease specific survival according to FGFR4 profile.</p

Immunohistochemical analysis of tumors.

<p>(a) strong FGFR4 expression; (b) weak FGFR4 expression. Magnification was 400×.</p

Epidemiological, clinical and pathological tumor features and their association with Gly388Arg polymorphism and FGFR4 expression.

a<p>Not available (not considered in the statistical calculations).</p

Survival plots.

<p><b>a. and b.:</b> Disease-free survival and disease-specific survival according to FAS expression; <b>c. and d.:</b> Disease-free survival and disease-specific survival according to FASL expression.</p