12 research outputs found
The effects of social and demographic variables on MDD risk.
<p>The effects of social and demographic variables on MDD risk.</p
Phenotypic correlations of MDD status (absent = 0, affected = 1) between kinship dyads.
<p>Estimates from 500 jack-knifed replicates that sampled a single pair from each family for full siblings (N families with one or more pairs = 4306), full sisters (N = 2239), full brothers (N = 1161), opposite sex full-siblings (N = 2426), parent-child (N = 3402), grandparent-grandchild (N = 391), avuncular (aunt/uncle-niece/nephew N = 1826), first cousins (N = 1194).</p
Sociodemographic comparison of GS:SFHS and the Scottish population.
<p>* People aged 16ā74 years</p><p><sup>a</sup> Scottish Executive (2012)</p><p><sup>b</sup> Scottish Executive (2006)</p><p>Sociodemographic comparison of GS:SFHS and the Scottish population.</p
Heritability, variance proportions, and stratified correlations of MDD.
<p>h<sup>2</sup> = heritability, r<sub>G</sub> = genetic correlation, c<sup>2</sup> = shared family environment, r<sub>C</sub> = shared family environment correlation.</p
Number of informative relationships for MDD and AOO pedigree analysis in GS:SFHS.
<p>Number of informative relationships for MDD and AOO pedigree analysis in GS:SFHS.</p
Kaplan-Meier survival curves for age of onset by age group.
<p>Kaplan-Meier survival curves for age of onset by age group.</p
Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis - Fig 1
<p><b>The association between Pfizer-23andMeāderived polygenic risk profiles scores for pain on chronic pain phenotypes in GS:SFHS (left panel) and UK Biobank (right panel).</b> This figure shows the association between polygenic risk scores for pain (derived from Pfizer-23andMe data) and chronic pain in GS:SFHS (left panel) and UK Biobank (right panel). Vertical <i>y</i>-axis represents the effect size as a standardised beta; horizontal axis represents the four alternative <i>p</i>-value thresholds used for the generation of polygenic scores in the discovery GWAS studies.</p
Association between polygenic risk of MDD and chronic pain phenotypes in GS:SFHS and UK Biobank.
<p>This figure shows the association between polygenic risk scores for MDD (derived from Psychiatric Genomics Consortium data) and chronic pain in GS:SFHS (left panel) and UK Biobank (right panel). Vertical <i>y</i>-axis represents the effect size as a standardised beta, horizontal axis represents the four alternative <i>p</i>-value thresholds used for the generation of polygenic scores in the discovery GWAS studies.</p
Association of polygenic profile scores for chronic pain and MDD in GS:SFHS.
<p>Association of polygenic profile scores for chronic pain and MDD in GS:SFHS.</p