The effects of social and demographic variables on MDD risk.

<p>The effects of social and demographic variables on MDD risk.</p

Phenotypic correlations of MDD status (absent = 0, affected = 1) between kinship dyads.

<p>Estimates from 500 jack-knifed replicates that sampled a single pair from each family for full siblings (N families with one or more pairs = 4306), full sisters (N = 2239), full brothers (N = 1161), opposite sex full-siblings (N = 2426), parent-child (N = 3402), grandparent-grandchild (N = 391), avuncular (aunt/uncle-niece/nephew N = 1826), first cousins (N = 1194).</p

Sociodemographic comparison of GS:SFHS and the Scottish population.

<p>* People aged 16–74 years</p><p>^a Scottish Executive (2012)</p><p>^b Scottish Executive (2006)</p><p>Sociodemographic comparison of GS:SFHS and the Scottish population.</p

Heritability, variance proportions, and stratified correlations of MDD.

<p>h² = heritability, r_G = genetic correlation, c² = shared family environment, r_C = shared family environment correlation.</p

Number of informative relationships for MDD and AOO pedigree analysis in GS:SFHS.

<p>Number of informative relationships for MDD and AOO pedigree analysis in GS:SFHS.</p

Age of onset distribution.

<p>Dashed line is the mean.</p

Kaplan-Meier survival curves for age of onset by age group.

<p>Kaplan-Meier survival curves for age of onset by age group.</p

Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis - Fig 1

<p><b>The association between Pfizer-23andMe–derived polygenic risk profiles scores for pain on chronic pain phenotypes in GS:SFHS (left panel) and UK Biobank (right panel).</b> This figure shows the association between polygenic risk scores for pain (derived from Pfizer-23andMe data) and chronic pain in GS:SFHS (left panel) and UK Biobank (right panel). Vertical <i>y</i>-axis represents the effect size as a standardised beta; horizontal axis represents the four alternative <i>p</i>-value thresholds used for the generation of polygenic scores in the discovery GWAS studies.</p

Association between polygenic risk of MDD and chronic pain phenotypes in GS:SFHS and UK Biobank.

<p>This figure shows the association between polygenic risk scores for MDD (derived from Psychiatric Genomics Consortium data) and chronic pain in GS:SFHS (left panel) and UK Biobank (right panel). Vertical <i>y</i>-axis represents the effect size as a standardised beta, horizontal axis represents the four alternative <i>p</i>-value thresholds used for the generation of polygenic scores in the discovery GWAS studies.</p

Association of polygenic profile scores for chronic pain and MDD in GS:SFHS.

<p>Association of polygenic profile scores for chronic pain and MDD in GS:SFHS.</p