Changes in nutrition type between generations influence on bone structural changes in rat female offspring

Background and Purpose: It is believed that changes in feeding protocol between generations have influence on the balance of the whole organism. Epidemiological studies suggest that skeletal growth is programmed during intrauterine and early postnatal life. The aim of the study was to determinate impact of maternal dietary fat excess and nutrition of female offspring on the bone structural changes in latter. Materials and Methods: Ten female Sprague Dawley rats were randomly divided in two groups. One group was fed with high content of saturated fatty acid food (HFD) and the other with standard laboratory chow (CD). Offspring from both groups were randomly divided in two subgroups after coupling and lactation period, subsequently there were four groups of offspring (n=6 each) with different feeding protocol: a) CD-CD – control diet mothers and offspring, b) CD-HFD – control diet mothers and high fat diet offspring, c) HFD-CD – high fat diet mothers and control diet offspring and d) HFD-HFD – high fat diet mothers and offspring. At the age of 18 weeks in female offspring bone microstructure was analyzed in fifth lumbar vertebra using digital photographic images. Results and Conclusions: The control diet female offspring of high fat fed mothers showed the highest values of trabecular thickness and trabecular number, while the CD-HFD offspring group had the highest values of trabecular separation and cortical thickness. Maternal nutritional status affects the future development of offspring

Changes in nutrition type between generations influence on bone structural changes in rat female offspring

Background and Purpose: It is believed that changes in feeding protocol between generations have influence on the balance of the whole organism. Epidemiological studies suggest that skeletal growth is programmed during intrauterine and early postnatal life. The aim of the study was to determinate impact of maternal dietary fat excess and nutrition of female offspring on the bone structural changes in latter. Materials and Methods: Ten female Sprague Dawley rats were randomly divided in two groups. One group was fed with high content of saturated fatty acid food (HFD) and the other with standard laboratory chow (CD). Offspring from both groups were randomly divided in two subgroups after coupling and lactation period, subsequently there were four groups of offspring (n=6 each) with different feeding protocol: a) CD-CD – control diet mothers and offspring, b) CD-HFD – control diet mothers and high fat diet offspring, c) HFD-CD – high fat diet mothers and control diet offspring and d) HFD-HFD – high fat diet mothers and offspring. At the age of 18 weeks in female offspring bone microstructure was analyzed in fifth lumbar vertebra using digital photographic images. Results and Conclusions: The control diet female offspring of high fat fed mothers showed the highest values of trabecular thickness and trabecular number, while the CD-HFD offspring group had the highest values of trabecular separation and cortical thickness. Maternal nutritional status affects the future development of offspring

Vježbanje i kvaliteta života kod žena starije dobi

Uvod: Starenje je fiziološka promjena kod čovjeka te je iznimno važno unapređivanje zdravlja i očuvanje funkcionalnih sposobnosti te kvalitete života. Cilj: Cilj rada je ispitati utjecaj vježbanja na kvalitetu života žena starije dobi. Materijali i metode: Uzorak je obuhvaćao 93 ispitanice (N=93). Ispitanice su osam tjedana dva puta tjedno u trajanju od 45 minuta provodile program vježbi ravnoteže i koordinacije, vježbe jačanja mišića i istezanja. Za procjenu kvalitete života korišteni su Upitnik o zdravlju EQ-5D-5L i McGill Pain upitnika (SF-MPQ). Rezultati: Dobiveni rezultati upućuju na poboljšanje pokretljivosti i uobičajenih aktivnosti (p>0,001) te smanjenje intenziteta boli (p<0,001). Zaključak: Rezultati istraživanja potvrđuju važnost vježbanja, te utjecaja na intenzitet boli i kvalitetu života osoba starije dobi

Vježbanje i kvaliteta života kod žena starije dobi

Uvod: Starenje je fiziološka promjena kod čovjeka te je iznimno važno unapređivanje zdravlja i očuvanje funkcionalnih sposobnosti te kvalitete života. Cilj: Cilj rada je ispitati utjecaj vježbanja na kvalitetu života žena starije dobi. Materijali i metode: Uzorak je obuhvaćao 93 ispitanice (N=93). Ispitanice su osam tjedana dva puta tjedno u trajanju od 45 minuta provodile program vježbi ravnoteže i koordinacije, vježbe jačanja mišića i istezanja. Za procjenu kvalitete života korišteni su Upitnik o zdravlju EQ-5D-5L i McGill Pain upitnika (SF-MPQ). Rezultati: Dobiveni rezultati upućuju na poboljšanje pokretljivosti i uobičajenih aktivnosti (p>0,001) te smanjenje intenziteta boli (p<0,001). Zaključak: Rezultati istraživanja potvrđuju važnost vježbanja, te utjecaja na intenzitet boli i kvalitetu života osoba starije dobi

Influence of Allergy and Bacterial Colonization on the Quality of Life in Nasal Polyposis Patients

Allergies and bacterial colonization are frequently found in patients with chronic rhinosinuitis with nasal polyposis (CRSwNP). The aim of this study was to identify patients with allergy and present microorganisms in ethmoid sinus among the patients with refractory CRSwNP undergoing surgical treatment at the University Hospital Centre Osijek, and to compare their life quality, defined by SNOT-20 analysis (sinonasal outcome test) to the rest of patients, and a con- trol group consisting of patients undergoing septoplasty but free of allergy and/or CRS. An additional aim was to iden- tify specific types and strains of microorganisms (bacteria and fungi) found in these patients, in order to compare them to other reports, and to revise the empirical antimicrobial therapy. In this paper we demonstrate a high incidence of bacte- rial colonization (83.3%) among CRSwNP patients. As in previous studies, gram positive aerobes were the most fre- quently isolated bacteria and all of them were covered by specific antibiotics given before the specimen collection. Allergy was found in only 20% of these patients, who presented with a reduced quality of life when compared to the control group and CRSwNP without allergy. Significantly more frequent dominant symptoms in these patients were cough, frustration and irritation. In the line with this finding is the objective assessment by endoscopy (Malm score) that showed more prominent nasal polyposis in allergy patients

Rheological, Microstructural and Thermal Properties of Magnetic Poly(Ethylene Oxide)/Iron Oxide Nanocomposite Hydrogels Synthesized Using a One-Step Gamma-Irradiation Method

Magnetic polymer gels are a new promising class of nanocomposite gels. In this work, magnetic PEO/iron oxide nanocomposite hydrogels were synthesized using the one-step γ-irradiation method starting from poly(ethylene oxide) (PEO) and iron(III) precursor alkaline aqueous suspensions followed by simultaneous crosslinking of PEO chains and reduction of Fe(III) precursor. γ-irradiation dose and concentrations of Fe3+, 2-propanol and PEO in the initial suspensions were varied and optimized. With 2-propanol and at high doses magnetic gels with embedded magnetite nanoparticles were obtained, as confirmed by XRD, SEM and Mössbauer spectrometry. The quantitative determination of γ-irradiation generated Fe2+ was performed using the 1, 10-phenanthroline method. The maximal Fe2+ molar fraction of 0.55 was achieved at 300 kGy, pH = 12 and initial 5% of Fe3+. The DSC and rheological measurements confirmed the formation of a well-structured network. The thermal and rheological properties of gels depended on the dose, PEO concentration and initial Fe3+ content (amount of nanoparticles synthesized inside gels). More amorphous and stronger gels were formed at higher dose and higher nanoparticle content. The properties of synthesized gels were determined by the presence of magnetic iron oxide nanoparticles, which acted as reinforcing agents and additional crosslinkers of PEO chains thus facilitating the one-step gel formation

The origins and characteristics of musculoskeletal pain in the elderly

Udio starijih osoba u populaciji tijekom posljednjih se nekoliko desetljeća višestruko povećao i očekuje se njegov daljnji progresivni rast.Mišićno-koštana bol visoko je zastupljena u osoba starije dobi, a njezini su najčešći uzroci: osteoartritis (kronična bol ramena,kukova, koljena), križobolja, fibromijalgija, miofascijalni bolni sindromi i mjesta prethodnih fraktura. Politopna distribucija boli, visoka stopa komorbiditeta te povećana incidencija nuspojava povezanih s liječenjem pridonose smanjenju kretanja, participacije i kvalitete života osoba starije dobi. Da bi se osigurao najučinkovitiji i najsigurniji terapijski pristup starijim osobama s mišićno-koštanom boli, prepoznavanje i učestala reevaluacija uzroka kronične boli te utjecaj na cjelokupno zdravlje imaju ključnu ulogu.Kombinacija farmakoterapije i nefarmakoloških metoda liječenja, uključujući timski biopsihosocijalni rehabilitacijski pristup, daje najbolje rezultate u smanjenju boli, poboljšanju funkcijskih sposobnosti, kognitivnoga funkcioniranja te ukupne kvalitete života osoba starije dobi.Over the last several decades the proportion of the elderly in the population has increased and future progressive growth is expected. Musculoskeletal pain is highly represented in the elderly; the most common causes are osteoarthritis, low back pain, fibromyalgia, chronic shoulder pain, knee and hip pain, myofascial pain syndrome and former fracture site.Polytopic pain distribution, high comorbidity rate and increased incidence of side effects associated with treatment contribute to the reduction of movement, as well as participation and life quality in the elderly. To ensure the most effective and safest therapy approach to the elderly with musculoskeletal pain, recognition and frequent re-evaluation of chronic pain causes and the impact on life quality play a key role. Pharmacotherapy and nonpharmacological treatment methods, including team biopsychosocial rehabilitation approach, ensure the best results in reducing pain, improving functional abilities, cognitive functioning and overall quality of life of elderly people

Validation and cross-cultural adaptation of the COMPASS-31 in Croatian and Serbian patients with multiple sclerosis

Aim To validate and cross-culturally adapt Croatian and Serbian versions of composite autonomic symptom score- 31 (COMPASS-31) for the detection of dysautonomia in patients with multiple sclerosis (MS). Methods A total of 179 patients, 67 with clinically isolated syndrome (CIS) and 112 with MS, completed the COMPASS- 31 at two MS centers in Zagreb and Belgrade between April 1 and October 31, 2016. Demographic and clinical data including age, gender, MS phenotypes, and the Expanded Disability Status Scale (EDSS) score were collected. Results The Cronbach’s alpha coefficient of COMPASS-31 total score was 0.844 for the Croatian MS sample and 0.779 for the Serbian MS sample. A joint analysis yielded Cronbach’s alpha coefficients ranging from 0.394 to 0.796, with values in four domains higher than 0.700. In Croatian and Serbian samples and the total study sample, the Cronbach’s alpha coefficient of COMPASS-31 was 0.785. Reproducibility measured by intra-class correlation coefficient (ICC) was acceptable (ICC = 0.795). With regard to the clinical validity, significant correlation was found between EDSS and the COMPASS-31 total score (P < 0.001). Furthermore, significant differences between MS phenotypes were detected for bladder and gastrointestinal domains and for the COMPASS-31 total score (P < 0.001, P = 0.005, and P = 0.027, respectively). Finally, significant differences between MS phenotypes in patients with score >0, which implies the existence of at least one of the symptoms investigated in each domain, were detected for secretomotor and bladder domains (P = 0.015 and P < 0.001, respectively). Conclusion COMPASS-31 represents a valid and acceptable self-assessment instrument for the detection of dysautonomia in MS patient