Additional file 6: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Figure S3. Expression levels of the top 500 most variable transcripts in CD4 and CD8 cells, shown for each of 135 samples. Sample groups are indicated by the orange (CD4) and blue (CD8) bars at the top of the heatmap. (DOCX 555 kb

Additional file 5: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S3. General disease outcome and prognostic measures. (DOCX 38 kb

Additional file 10: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S7. Significant CD4 genes shared by phenotypes at T1. (CSV 4 kb

Additional file 7: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S4. Differential expression results CD4. (XLSX 272 kb

Additional file 3: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Figure S2. Effect of batch correction on 195 samples (2 samples of the 197 were removed). Three parameters (Flowcell ID, Gender and Ethnicity) were used to remove confounding effects in edgeR. PC1 contributes the greatest amount of variance and is largely attributed to Flowcell ID, which accounts for most of the variance in sequencing experiments. (DOCX 384 kb

Additional file 11: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S8. Significant CD8 genes shared by phenotypes at T1. (CSV 5 kb

Additional file 2: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Figure S1. Quality control metrics for stored specimens. Representative FACS analysis for FITC bound CD4 (A) and APC bound CD8 cells (B). Panel C displays the FACS confirmed purity of all specimens, with case and control samples represented by red and blue triangles respectively. (DOCX 100 kb

Additional file 9: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S6. Significant polynomial modelling results. (XLSX 62 kb

Additional file 1: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S1. Cases recruited and attendance for all 6 time points (DOCX 160 kb

Additional file 8: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S5. Differential expression results CD8. (XLSX 1097 kb