Personalized computer simulations of a NeoAva non-responder patient: comparison of standard and alternative schedules

The videos show personalized computer simulation of a breast tumor portion under the combined effect of chemotherapy and anti-angiogenic treatment. The simulations corresponds to 12 weeks of therapy in a luminal non-responder patient of the NeoAva clinical trial using standard and alternative schedules. Cancer, stroma cells and oxygen tension are shown. To produce the simulations we use a multiscale pharmacokinetic and pharmacodynamic model informed by individual, multisource clinical data, including histological, molecular and magnetic resonance imaging data. See reference below

Breast MRI as a building block for patient-specific simulations of drug effect

Poster presented in the 4th Symposium of Nordic Association for Clinical Physics, Bridging Imaging and Therapy, February 6 – 8, 2017 Oslo, Norwa

Personalized Computer Simulations of Breast Cancer Tumors Treated with Neoadjuvant Chemotherapy and Bevacizumab

Poster presented at Personalized Cancer Care Symposium, Oslo 2016: http://pccradiumhospital.org/<div><br></div