Formulation and research of the solid disper systems of spironolactone

Introduction: Starting from the fact that spironolactone is practically insoluble in water, its formulation orodispersible is important to enhance dissolution rapid absorption from the oral cavity. Aim: To increase the solubility of spironolactone was evaluated its association with different solubilized to form solid disperse systems. . Material and method: Preparation o f solid dispersion systems: Solid dispersion was obtained using the combined method: solvent evaporation and melting. Spironolactone and polyvinylpyrrolidone is dissolved in ethyl alcohol 96%. The resulting solution is left to complete evaporation of ethanol. Polyethylene glycol 4000 melts at a temperature of + 60° C, the mixture plus spironolactone and polyvinylpyrrolidone. Stir continuously until completely cooled. Parallel to prepare and physical mixture of spironolactone, polyvinylpyrrolidone and polyethylene glycol. Thermo-gravimetric analysis: Substances studied, physical mixture and solid dispersion were subjected to thermo-gravimetric analysis derivatographic O1500D model MOM (Hungary). Samples were heated to a temperature of 1020° C, the heating rate of 10° C/min. He sought modification of the caloric content of substances and mixtures, recorded temperature variation, in the mass during heat treatment. Results: The dispersed solid is characterized the 3 effects of decomposition in the temperature range 45 to 471° C, the mass loss of 86.96%. At a temperature of about 60° C the degradation of the system is associated with an endothermic effect, characteristic of a melting process which confirms that the system presents a phase change. There follows a series of endothermic and exothermic effects. Total mass loss is 97.91%. Conclusions: The results confirm the formation of a solid dispersed system of spironolactone with polyvinylpyrrolidone and Polyethylene glycol 4000

Study of the disintegration methods of orally disintegrating spironolactone tablets

Catedra Tehnologia medicamentelorStudy of the disintegration methods of orally disintegrating spironolactone tablets An alternative disintegration method for orally orodispersable tablets has been proposed. This test is the nearest to in vivo conditions. The respective apparatus was proposed for this investigation. A fost elaborată o metodă alternativă de evaluare a timpului de dezagregare a comprimatelor orodispersabile. Acest test este cel mai apropiat de condiţiile in vivo. S-a propus dispozitivul respectiv pentru efectuarea acestei cercetări

Study of the capacity to absorb water and porosity value with Spironolactone orodispersible tablets

Laboratorul de Tehnologie farmaceutică şi transfer tehnologic al Centrului Ştiinţific în domeniul medicamentului Catedra Tehnologia medicamentelor USMF „Nicolae Testemiţanu”Physical properties were investigated orodispersible with spironolactone tablets. It was observed that a greater capacity to absorb water in the first 2 minutes is observed at all values of the compression. Appreciable volume changes observed in the tablets obtained from the pressure of 120 N and a polymer concentration of 15%, the volume increased 5 times. 3. For tablets witness porosity values are lower and a pressure of 200 N of 3.43% is only 2.4 times lower than the tablets with crospovidone (8.36%). Au fost cercetate proprietăţile fizice ale comprimatelor orodispersabile cu spironolactonă. S-a observat că o capacitate mai mare de absorbţie a apei se observă în primele 2 minute, la toate valorile presiunii de comprimare. Modificări de volum mai apreciabile se observă la comprimatele obţinute la valoarea presiunii de 120 N şi o concentraţie a polimerului de 15%, la care volumul s-a mărit de 5 ori. 3. Pentru comprimatele martor valorile porozităţii sunt mai mici şi la presiunea de 200 N este doar de 3,43 % de 2,4 ori mai scăzută decât la comprimatele cu crospovidonă (8,36 %)

Study of the physical properties of chlorpheniramine maleate orodispersible tablets

Laboratorul de Tehnologie farmaceutică şi transfer tehnologic al Centrului ştiinţific în domeniul medicamentului Catedra Tehnologia medicamentelor USMF „Nicolae Testemiţanu”Were investigated physical properties of chlorpheniramine maleate with tablets orodispersible. It is observed that with increasing porosity tablet compression pressure value decreases. Simultaneously increases the tablet disintegration time for all methods of determination. A higher capacity of water absorption is observed in the first 3 minutes, all the compression values. Appreciable volume changes observed in the tablets obtained from the pressure of 120 N and croscarmellose sodium concentration of 30%, the volume increased 6 times. Au fost cercetate proprietăţile fizice ale comprimatelor orodispersabile cu maleat de clorfeniramină. S-a observat că, odată cu creşterea valorii presiunii de comprimare porozitatea comprimatelor scade. Concomitent creşte timpul de dezagregare al comprimatelor, pentru toate metodele de determinare. O capacitate mai mare de absorbţie a apei se observă în primele 3 minute, la toate valorile presiunii de comprimare. Modificări de volum mai apreciabile se observă la comprimatele obţinute la valoarea presiunii de 120 N şi o concentraţie a croscarmelozei sodice de 30%, la care volumul s-a mărit de 6 ori

Optimization of the formulation orodispersable tablets of chlorpheniramine maleate

Catedra Tehnologia medicamentelor, Laboratorul Tehnologie farmaceutică şi transfer tehnologic al Centrului Ştiinţific în domeniul Medicamentului a USMF „Nicolae Testemiţanu”The purpose of this research was to develop mouth dissolve tablets of Chlorpheniramine maleate. Tablets were prepared by direct compression. The tablets were evaluated for disintegration time and hardness test. In the investigation, a 32 full factorial design was used to investigate the joint influence of 2 formulation variables: amount of Croscarmellose sodium and Lactose. The results of multiple linear regression analysis revealed that for obtaining of a rapidly disintegration dosage form, tablets should be prepared using an optimum concentration of Lactose and higher percentage of Croscarmellose sodium. Au fost cercetate comprimatele orodispersabile cu maleat de clorfeniramină, preparate prin comprimare directă. A fost evaluat timpul de dezagregare şi rezistenţa mecanică. Pentru optimizarea formulării a fost folosit designul factorial deplin randomizat 32 . Croscarmeloza sodică şi lactoza au fost selectate ca variabile independente. În rezultatul analizei multiple regresionale a fost relevat raportul optimal al cantităţilor de croscarmeloză şi lactoză care permit obţinerea valorilor scontate ale timpului de dezagregare şi al rezistenţei mecanice a comprimatelor cu dezagregare rapidă