The best of the UK? A report on the value and future of UK databases in the health and social care fields: a systematic map protocol

INTRODUCTION: This protocol covers the first part of a two-part project funded by the Health Libraries Group and the University Health and Medical Librarians Group. It details the proposed methodology for a systematic map of the literature relating to UK bibliographic databases in the fields of health and social care. The aim of this mapping exercise is to consider ways in which UK bibliographic databases are described, considered and discussed in the published and unpublished literature. In doing so, we hope to gain a clearer sense of the ways in which UK bibliographic databases are used and viewed by the research community. It also enables the identification of any gaps in the literature for further research and discussion. This topic is important because UK databases are generally underused by researchers in the UK context and some databases are at risk of closure. A lack of access to UK databases means that researchers may miss relevant UK evidence when identifying an evidence base. / METHOD: Systematic Map. / ANALYSIS: The authors will present a narrative description of the literature relating to UK bibliographic databases in the fields of health and social care. They will use tables to present descriptive information about the literature (eg, frequency tables) and use cross-tabulations to demonstrate intersecting themes. Separately, guidance on how to use the resources (eg, areas of unique content, updating frequencies, unique truncation symbols) will be sought from stakeholders and reported alongside the report narrative as a guide to usage

Community perceptions of bushfire risk

The public often view and evaluate risk differently from researchers and experts. Understanding how the public construct their perceptions of risk can greatly improve risk communication, and direct risk reduction strategies most appropriately. This chapter explores the social construction of risk in two peri-urban bushfire-prone communities in Queensland. These case studies were undertaken in 2005 using a multiplemethods approach, which included group interviews with community and fire brigade members, and a community survey. While there are common factors that can similarly influence perceptions of bushfire risks within and between communities, there are often local-based issues unique to a community that have important implications for bushfire management. Through understanding and clarifying fire issues in communities, fire managers can address problems affecting bushfire risk mitigation in their local cOl1ullUnily. Engaging the community through a number of means could help considerably. The community should be viewed as a resource - communities have the capacity to act, despite vulnerabilities

Stratigraphy of a Lateglacial lake basin sediment sequence at Turret Bank, upper Glen Roy, Lochaber: implications for the age of the Turret Fan

New lithostratigraphical, pollen-stratigraphical and tephrostratigraphical data are presented for a sediment sequence at Turret Bank, a site that lies close to the confluence of the River Turret with the River Roy in Lochaber, the western Scottish Highlands. The site is also adjacent to the inner margin of a major gravel fan, the Glen Turret Fan, the age of which has been debated and has a crucial bearing on the overall sequence of events in Glen Roy, especially concerning the maximum limit of Loch Lomond Readvance (Younger Dryas) ice. Several lines of evidence point to the sediment sequence at Turret bank having been wholly deposited during the Loch Lomond Stadial-early Holocene transition: (i) the pollen sequence is typical for this transitional period; (ii) varved deposits preserved in the sequence bear a strong resemblance to mid-Stadial varves in a regional master varve scheme for Glen Roy and vicinity (the Lochaber Master Varve Chronology); and (iii) an early Holocene tephra – the Askja-S Tephra – is preserved within the sequence. Some limitations with the new data are considered, but it is concluded that the coherent integration of lithostratigraphic, geomorphological, pollen-stratigraphical and tephrostratigraphical data point to the likelihood that Loch Lomond Readvance ice extended to the inner margin of the Glen Turret Fan, and that the fan was probably constructed by glacial meltwaters at this time

Indicators of climate risk in the UK at different levels of warming

Assessments of the impacts of climate change are typically made using climate scenarios based on assumptions about future emissions of greenhouse gases, but policymakers and climate risk communicators are increasingly asking for information on impacts at different levels of warming. This paper provides this information for a set of indicators of climate risks in the UK for levels of warming up to 4 °C above pre-industrial levels. The results show substantial increases in climate risks at 2 °C, which is often inferred in the media to be a 'safe' level of climate change. In a 2 °C world, the chance of a heatwave is doubled, and the frequency of heat stress affecting people, crops and animals can be increased by a factor of five. Cooling degree days more than double, wildfire danger can increase by 40%–70%, the frequency of agricultural and water resources droughts doubles in England, and flood frequency in Wales increases by 50%. At 4 °C the increases in risk are considerably greater: heatwaves occur in virtually every year. The frequency of cold weather extremes reduces, but is not eliminated, with increasing warming. The rate of change in an indicator with warming varies across the UK. For temperature-based indicators this reflects variability in current climate, but for rainfall-based indicators reflects variations in the change in climate. Most indicators show a generally linear increase in risk with level of warming (although the change in risk from now is around 2.4 times higher in a 4 °C world than a 2 °C world because of warming experienced so far). However, some indicators—particularly relating to heat extremes—show a highly non-linear increase with level of warming. The range in change in indicator at a given level of warming is primarily caused by uncertainty in the estimated regional response of to increasing forcing

Clinical indicators of bacterial meningitis among neonates and young infants in rural Kenya

<p>Abstract</p> <p>Background</p> <p>Meningitis is notoriously difficult to diagnose in infancy because its clinical features are non-specific. World Health Organization (WHO) guidelines suggest several indicative signs, based on limited data. We aimed to identify indicators of bacterial meningitis in young infants in Kenya, and compared their performance to the WHO guidelines. We also examined the feasibility of developing a scoring system for meningitis.</p> <p>Methods</p> <p>We studied all admissions aged < 60 days to Kilifi District Hospital, 2001 through 2005. We evaluated clinical indicators against microbiological findings using likelihood ratios. We prospectively validated our findings 2006 through 2007.</p> <p>Results</p> <p>We studied 2,411 and 1,512 young infants during the derivation and validation periods respectively. During derivation, 31/1,031 (3.0%) neonates aged < 7 days and 67/1,380 (4.8%) young infants aged 7-59 days (p < 0.001) had meningitis. 90% of cases could be diagnosed macroscopically (turbidity) or by microscopic leukocyte counting. Independent indicators of meningitis were: fever, convulsions, irritability, bulging fontanel and temperature ≥ 39°C. Areas under the receiver operating characteristic curve in the validation period were 0.62 [95%CI: 0.49-0.75] age < 7 days and 0.76 [95%CI: 0.68-0.85] thereafter (P = 0.07), and using the WHO signs, 0.50 [95%CI 0.35-0.65] age < 7 days and 0.82 [95%CI: 0.75-0.89] thereafter (P = 0.0001). The number needed to LP to identify one case was 21 [95%CI: 15-35] for our signs, and 28 [95%CI: 18-61] for WHO signs. With a scoring system, a cut-off of ≥ 1 sign offered the best compromise on sensitivity and specificity.</p> <p>Conclusion</p> <p>Simple clinical signs at admission identify two thirds of meningitis cases in neonates and young infants. Lumbar puncture is essential to diagnosis and avoidance of unnecessary treatment, and is worthwhile without CSF biochemistry or bacterial culture. The signs of Meningitis suggested by the WHO perform poorly in the first week of life. A scoring system for meningitis in this age group is not helpful.</p

A primer for use of genetic tools in selecting and testing the suitability of set-aside sites protected from deep-sea seafloor massive sulfide mining activities

AbstractSeafloor massive sulfide (SMS) mining will likely occur at hydrothermal systems in the near future. Alongside their mineral wealth, SMS deposits also have considerable biological value. Active SMS deposits host endemic hydrothermal vent communities, whilst inactive deposits support communities of deep water corals and other suspension feeders. Mining activities are expected to remove all large organisms and suitable habitat in the immediate area, making vent endemic organisms particularly at risk from habitat loss and localised extinction. As part of environmental management strategies designed to mitigate the effects of mining, areas of seabed need to be protected to preserve biodiversity that is lost at the mine site and to preserve communities that support connectivity among populations of vent animals in the surrounding region. These “set-aside” areas need to be biologically similar to the mine site and be suitably connected, mostly by transport of larvae, to neighbouring sites to ensure exchange of genetic material among remaining populations. Establishing suitable set-asides can be a formidable task for environmental managers, however the application of genetic approaches can aid set-aside identification, suitability assessment and monitoring. There are many genetic tools available, including analysis of mitochondrial DNA (mtDNA) sequences (e.g. COI or other suitable mtDNA genes) and appropriate nuclear DNA markers (e.g. microsatellites, single nucleotide polymorphisms), environmental DNA (eDNA) techniques and microbial metagenomics. When used in concert with traditional biological survey techniques, these tools can help to identify species, assess the genetic connectivity among populations and assess the diversity of communities. How these techniques can be applied to set-aside decision making is discussed and recommendations are made for the genetic characteristics of set-aside sites. A checklist for environmental regulators forms a guide to aid decision making on the suitability of set-aside design and assessment using genetic tools. This non-technical primer document represents the views of participants in the VentBase 2014 workshop

Progressing the science of effluent treatment using Lasersizer diffraction analysis - a pilot study

Disinfection of waste water with ultraviolet (UV) light is a common procedure in many sewage treatment plants because it is used to inactivate coliform bacteria in the effluent. The number of coliform bacteria in a given sample is used as a proxy to indicate the presence of targeted pathogenic organisms. Typically the coliform bacteria exist in a particle-associated state which results in their being shielded from the UV light (Darby et al., 1999). Such particles are documented in the size range 20 to 80 μm, and therefore measurement of the size distribution in a sample could be used to indicate the degree of shielding. UV treatment is less effective for particles larger than about 40 μm in size (Table 1). Our pilot study used the laser diffraction technique to generate particle-size distributions of samples of effluent. By quantifying the amount of bacteria-shielding particles using this technique we were able to estimate the general efficacy of the UV sterilization process. The surface weighted mean diameter statistic was taken as a numerical measure of the bacteriashielding particle size distribution

An educational intervention to prevent overweight in pre-school years: a cluster randomised trial with a focus on disadvantaged families

Background: Early prevention is a promising strategy for reducing obesity in childhood, and Early Years settings are ideal venues for interventions. This work evaluated an educational intervention with the primary aim of preventing overweight and obesity in pre-school children. Methods: A pragmatic, cluster randomised trial with a parallel, matched-pair design was undertaken. Interventions were targeted at both the cluster (Early Years’ Centres, matched by geographical area) and individual participant level (families: mother and 2-year old child). At the cluster level, a staff training intervention used the educational resource Be Active, Eat Healthy. Policies and provision for healthy eating and physical activity were evaluated at baseline and 12-months. The intervention at participant level was the Healthy Heroes Activity Pack: delivered over 6 months by Centre staff to promote healthy eating and physical activity in a fun, interactive way. Child and parent height and weight were measured at four time-points over two years. The trial primary outcome was the change in BMI z-score of the child between ages 2 and 4 years. Secondary outcomes consisted of parent-reported measures administered at baseline and two-year follow-up. Results: Five pairs of Early Years’ Centres were recruited. Four pairs were analysed as one Centre withdrew (47 intervention families; 34 control families). At the cluster level, improvement in Centre policies and practices was similar for both groups (p=0.830). At the participant level, the intervention group reduced their mean BMI z-score between age 2 and 4 years (p=0.002; change difference 0.49; 95% CI 0.17 to 0.80) whereas the control group showed increasing BMI z-score throughout. Changes in parent-reported outcomes and parent BMI (p=0.582) were similar in both groups. Conclusions: The Healthy Heroes educational resource deterred excess weight gain in pre-school children from poor socioeconomic areas. With training, Early Years’ staff can implement the Healthy Heroes programme. Trial Registration Number ISRCTN22620137 Registered 21st December 201

Developing H++ climate change scenarios for heat waves, droughts, floods, windstorms and cold snaps

This report describes the results of a project to investigate the development of plausible high-end climate change scenarios. It covers the following climate hazards: heat waves, cold snaps, low and high rainfall, droughts, floods and windstorms. The scope of the project does not extend into defining the consequences of these hazards such as mortality, property damage or impacts on the natural environment. The scenarios created for this report are referred to as H++ scenarios, and are typically more extreme climate change scenarios on the margins or outside of the 10th to 90th percentile range presented in the 2009 UK climate change projections (also known as ‘UKCP09’)