15 research outputs found
Main clinical characteristics of COPD patients switching of Clusters between visit 1 and visit 2.
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Correlation analyses between the 15 differentially regulated proteins and main clinical parameters in COPD patients of the COBRA cohort.
Correlation analyses between the 15 differentially regulated proteins and main clinical parameters in COPD patients of the COBRA cohort.</p
Biological classification of the top 90 proteins enriched in Cluster 2 COPD patients.
Biological classification of the top 90 proteins enriched in Cluster 2 COPD patients.</p
Two COPD patient Clusters show differentially expressed proteins enriched for distinct biological pathways.
(A) Volcano plot showing differentially expressed proteins between Cluster 1 and Cluster 2. X axis corresponds to log2 (fold change) and Y axis corresponds to -log10 (FDR). Yellow indicates proteins with significant downregulation and blue indicates those with significant upregulation (Fold change >1.5 and FDR versus Cluster 1, regrouped in three core functions defined as “Immunity and defense”, “Cell fate, repair and remodeling”, and “Metabolism and mitochondria”.</p
Differences in clinical characteristics between COPD patients of Cluster 1 and Cluster 2 at visit 1.
Differences in clinical characteristics between COPD patients of Cluster 1 and Cluster 2 at visit 1.</p