Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights

There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve functional tumour-associated blood vessel deterioration and normalisation. The former aims at tumour infarction and nutrient deprivation medi- ated by vascular targeting agents that induce occlusion/collapse of tumour blood vessels. In contrast, the therapeutic intention of normalising the abnormal structure and function of tumour vascular net- works, e.g. via alleviating stress-induced vaso-occlusion, is to improve chemo-, immuno- and radiation therapy efficacy. Although both strategies have shown therapeutic potential, it remains unclear why they often fail to control glioma invasion into the surrounding healthy brain tissue. To shed light on this issue, we propose a mathematical model of glioma invasion focusing on the interplay between the mi- gration/proliferation dichotomy (Go-or-Grow) of glioma cells and modulations of the functional tumour vasculature. Vaso-modulatory interventions are modelled by varying the degree of vaso-occlusion. We discovered the existence of a critical cell proliferation/diffusion ratio that separates glioma invasion re- sponses to vaso-modulatory interventions into two distinct regimes. While for tumours, belonging to one regime, vascular modulations reduce the tumour front speed and increase the infiltration width, for those in the other regime the invasion speed increases and infiltration width decreases. We show how these in silico findings can be used to guide individualised approaches of vaso-modulatory treatment strategies and thereby improve success rates

Critical Point Theory and the Number of Solutions of a Nonlinear Dirichlet Problem

No abstract provided

Organizaciones populares, construcción de identidad y acción política

El artículo analiza la experiencia de algunas organizaciones populares urbanas en Bogotá durante las últimas décadas del Siglo XX. La hipótesis principal es que estas asociaciones contribuyen a la conformación de los pobladores populares como sujetos sociales, al fortalecer su tejido social y asociativo, al afirmar identidades culturales y al crear nuevas prácticas y subjetividades políticas democráticas. La metodología empleada fue participativa y combinó investigación documental y siete estudios de caso.En primer lugar, se presenta el contexto histórico en el que surgen las organizaciones estudiadas, así como las dinámicas generadas por ellas y que han influido en el tejido social y asociativo en los barrios. También presenta las estrategias culturales que desarrollan las organizaciones, así como las concepciones y prácticas políticas que contribuyen a la constitución de nuevas identidades sociales y ciudadanías críticas.-1. Presentación. 2. Surgimiento y trayectoria de las organizaciones. 3. Las organizaciones y el tejido social local. 4. La identidad de las organizaciones. 5. La política de las organizaciones. Bibliografía

Estimating the Effects of Lenght of Exposure to Traning Program: The Case of Job Corps

Length of exposure to a training program is important in determining the labor market outcomes of participants. Employing methods to estimate the causal effects from continuous treatments, we provide insights regarding the effects of different lengths of enrollment to Job Corps (JC)— America’s largest and most comprehensive job training program for disadvantaged youth. We semiparametrically estimate average causal effects (on the treated) of different lengths of exposure to JC, using the “generalized propensity score” under the assumption that selection into different lengths is based on a rich set of observed covariates. “Placebo tests” are performed to gauge the plausibility of this assumption. We find that the estimated effects are increasing in the length of training, and that the marginal effects of additional training are decreasing with length of enrollment. We also document differences in the estimated effects of length of exposure across different demographic groups, which are particularly large between males and females. Finally, our results suggest an important “lock-in” effect in JC training.Training Programs, Continuous Treatments, Generalized Propensity Score, Dose-Response Function

Some Unique Constants Associated with Extremal Black Holes

In recent papers we had developed a unified picture of black hole entropy and curvature which was shown to lead to Hawking radiation. It was shown that for any black hole mass, holography implies a phase space of just one quantum associated with the interior of the black hole. Here we study extremal rotating and charged black holes and obtain unique values for ratios of angular momentum to entropy, charge to entropy, etc. It turns out that these ratios can be expressed in terms of fundamental constants in nature, having analogies with other physical systems, like in condensed matter physics.Comment: "Accepted for publication in Astrophysics & Space Science" 4 pages, 10 equation

Water vapor emission from IRC+10216 and other carbon-rich stars: model predictions and prospects for multitransition observations

We have modeled the emission of H2O rotational lines from the extreme C-rich star IRC+10216. Our treatment of the excitation of H2O emissions takes into account the excitation of H2O both through collisions, and through the pumping of the nu2 and nu3 vibrational states by dust emission and subsequent decay to the ground state. Regardless of the spatial distribution of the water molecules, the H2O 1_{10}-1_{01} line at 557 GHz observed by the Submillimeter Wave Astronomy Satellite (SWAS) is found to be pumped primarily through the absorption of dust-emitted photons at 6 $\mu$m in the nu2 band. As noted by previous authors, the inclusion of radiative pumping lowers the ortho-H2O abundance required to account for the 557 GHz emission, which is found to be (0.5-1)x10^{-7} if the presence of H2O is a consequence of vaporization of orbiting comets or Fischer-Tropsch catalysis. Predictions for other submillimeter H2O lines that can be observed by the Herschel Space Observatory (HSO) are reported. Multitransition HSO observations promise to reveal the spatial distribution of the circumstellar water vapor, discriminating among the several hypotheses that have been proposed for the origin of the H2O vapor in the envelope of IRC+10216. We also show that, for observations with HSO, the H2O 1_{10}-1_{01} 557 GHz line affords the greatest sensitivity in searching for H2O in other C-rich AGB stars.Comment: 35 pages, 12 figures, to be published in The Astrophysical Journa

Resonating bipolarons

Electrons coupled to local lattice deformations end up in selftrapped localized molecular states involving their binding into bipolarons when the coupling is stronger than a certain critical value. Below that value they exist as essentially itinerant electrons. We propose that the abrupt crossover between the two regimes can be described by resonant pairing similar to the Feshbach resonance in binary atomic collision processes. Given the intrinsically local nature of the exchange of pairs of itinerant electrons and localized bipolarons, we demonstrate the occurrence of such a resonance on a finite-size cluster made out of metallic atoms surrounding a polaronic ligand center.Comment: 7 pages, 4 figures, to be published in Europhysics Letter